Entity Details

Primary name FOLR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15328
EntryNameFOLR1_HUMAN
FullNameFolate receptor alpha
TaxID9606
Evidenceevidence at protein level
Length257
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesFOLR1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001947 heart looping
GO:0003147 neural crest cell migration involved in heart formation
GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0005542 folic acid binding
GO:0005634 nucleus
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0007155 cell adhesion
GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0015884 folic acid transport
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030133 transport vesicle
GO:0030136 clathrin-coated vesicle
GO:0031103 axon regeneration
GO:0031362 anchored component of external side of plasma membrane
GO:0031526 brush border membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0035036 sperm-egg recognition
GO:0038023 signaling receptor activity
GO:0046655 folic acid metabolic process
GO:0048208 COPII vesicle coating
GO:0051870 methotrexate binding
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061626 pharyngeal arch artery morphogenesis
GO:0061713 anterior neural tube closure
GO:0061714 folic acid receptor activity
GO:0070062 extracellular exosome
GO:0071231 cellular response to folic acid
GO:1904447 folate import across plasma membrane

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Cytoplasmic vesicle
Endosome
Secreted

Domains

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DomainNameCategoryType
IPR004269 Folate receptorFamilyFamily
IPR018143 Folate receptor-likeDomainDomain
IPR032935 Folate receptor alphaFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00158 Folic acidDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB05168 VintafolideDrugbanksmall molecule
DB05595 FarletuzumabDrugbankbiotech

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
FOLR1_HUMANCUL3_HUMANBioGRID, IntAct21988832 details
FOLR1_HUMANIRAK3_HUMANBioGRID, IntAct21988832 details
FOLR1_HUMANCNDH2_HUMANBioGRID, IntAct21988832 details
FOLR1_HUMANS35F6_HUMANBioGRID, IntAct32296183 details
FOLR1_HUMANLT4R2_HUMANBioGRID, MINT28298427 details