Entity Details

Primary name MGMT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16455
EntryNameMGMT_HUMAN
FullNameMethylated-DNA--protein-cysteine methyltransferase
TaxID9606
Evidenceevidence at protein level
Length207
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesMGMT

GO terms

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GOName
GO:0003677 DNA binding
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006266 DNA ligation
GO:0006281 DNA repair
GO:0006307 DNA dealkylation involved in DNA repair
GO:0008168 methyltransferase activity
GO:0009008 DNA-methyltransferase activity
GO:0016020 membrane
GO:0043066 negative regulation of apoptotic process
GO:0046872 metal ion binding
GO:2000781 positive regulation of double-strand break repair

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active siteSiteActive site
IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domainDomainDomain
IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA bindingDomainDomain
IPR036217 Methylated DNA-protein cysteine methyltransferase, DNA binding domainFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036631 Methylated DNA-protein cysteine methyltransferase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00151 CysteineDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB02216 S-MethylcysteineDrugbanksmall molecule
DB04531 S-BenzylcysteineDrugbanksmall molecule
DB11831 DinitrochlorobenzeneDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

76 interactions

InteractorPartnerSourcesPublicationsLink
MGMT_HUMANCSK21_HUMANBioGRID, HPRD10667577 details
MGMT_HUMANCSK22_HUMANBioGRID10667577 details
MGMT_HUMANKAPCA_HUMANBioGRID, HPRD10667577 details
MGMT_HUMANKPCA_HUMANBioGRID, HPRD10667577 12430183 details
MGMT_HUMANESR1_HUMANBioGRID11564893 details
MGMT_HUMANPCNA_HUMANBioGRID16226712 29510343 details
MGMT_HUMANCBP_HUMANBioGRID, HPRD11564893 details
MGMT_HUMANEP300_HUMANBioGRID, HPRD11564893 details
MGMT_HUMANSMC1A_HUMANBioGRID16226712 details
MGMT_HUMANH4_HUMANBioGRID16226712 details
MGMT_HUMANH2A1_HUMANBioGRID16226712 details
MGMT_HUMANH2BFM_HUMANBioGRID16226712 details
MGMT_HUMANH31T_HUMANBioGRID16226712 details
MGMT_HUMANMCM3_HUMANBioGRID16226712 details
MGMT_HUMANMSH2_HUMANBioGRID16226712 details
MGMT_HUMANTOP1_HUMANBioGRID16226712 details
MGMT_HUMANPRKDC_HUMANBioGRID16226712 details
MGMT_HUMANXRCC6_HUMANBioGRID16226712 details
MGMT_HUMANDDX5_HUMANBioGRID16226712 details
MGMT_HUMANDDX24_HUMANBioGRID16226712 details
MGMT_HUMANUBP19_HUMANBioGRID16226712 details
MGMT_HUMANRNF8_HUMANBioGRID16226712 details
MGMT_HUMANPSME2_HUMANBioGRID16226712 details
MGMT_HUMANUBB_HUMANBioGRID16226712 details
MGMT_HUMANPSMD9_HUMANBioGRID16226712 details
MGMT_HUMANFBX2_HUMANBioGRID16226712 details
MGMT_HUMANFBX27_HUMANBioGRID16226712 details
MGMT_HUMANHS90A_HUMANBioGRID16226712 details
MGMT_HUMANHS90B_HUMANBioGRID16226712 details
MGMT_HUMANCDK12_HUMANBioGRID16226712 details
MGMT_HUMANCDK10_HUMANBioGRID16226712 details
MGMT_HUMANKPCL_HUMANBioGRID16226712 details
MGMT_HUMANPRP4_HUMANBioGRID16226712 details
MGMT_HUMANCDKL5_HUMANBioGRID16226712 details
MGMT_HUMANSET_HUMANBioGRID16226712 details
MGMT_HUMANPTN4_HUMANBioGRID16226712 details
MGMT_HUMAN1433Z_HUMANBioGRID16226712 details
MGMT_HUMANIMB1_HUMANBioGRID16226712 details
MGMT_HUMANWNT9B_HUMANBioGRID16226712 details
MGMT_HUMANPABP3_HUMANBioGRID16226712 details
MGMT_HUMANAN32E_HUMANBioGRID16226712 details
MGMT_HUMANNUCL_HUMANBioGRID16226712 details
MGMT_HUMANROA2_HUMANBioGRID16226712 details
MGMT_HUMANHNRPC_HUMANBioGRID16226712 details
MGMT_HUMANRS15A_HUMANBioGRID16226712 details
MGMT_HUMANRLA1_HUMANBioGRID16226712 details
MGMT_HUMANEIF3H_HUMANBioGRID16226712 details
MGMT_HUMANEF1A1_HUMANBioGRID16226712 details
MGMT_HUMANEF1A2_HUMANBioGRID16226712 details
MGMT_HUMANEF1B_HUMANBioGRID16226712 details
MGMT_HUMANADT1_HUMANBioGRID16226712 details
MGMT_HUMANADT3_HUMANBioGRID16226712 details
MGMT_HUMANKPYM_HUMANBioGRID16226712 details
MGMT_HUMANTTPA_HUMANBioGRID16226712 details
MGMT_HUMANIL25_HUMANBioGRID16226712 details
MGMT_HUMANFBRL_HUMANBioGRID16226712 details
MGMT_HUMANTBB4B_HUMANBioGRID16226712 details
MGMT_HUMANTBA1C_HUMANBioGRID16226712 details
MGMT_HUMANANXA1_HUMANBioGRID16226712 details
MGMT_HUMANANXA2_HUMANBioGRID16226712 details
MGMT_HUMANACTB_HUMANBioGRID16226712 details
MGMT_HUMANMYO7A_HUMANBioGRID16226712 details
MGMT_HUMANVIME_HUMANBioGRID16226712 details
MGMT_HUMANPHB_HUMANBioGRID16226712 details
MGMT_HUMANSRP09_HUMANBioGRID16226712 details
MGMT_HUMANSSRP1_HUMANBioGRID16226712 details
MGMT_HUMANCDK2_HUMANBioGRID16226712 29510343 details
MGMT_HUMANCDK1_HUMANBioGRID16226712 details
MGMT_HUMANCCNB1_HUMANBioGRID16226712 details
MGMT_HUMANCDN1A_HUMANBioGRID16226712 29510343 details
MGMT_HUMANMCM2_HUMANBioGRID16226712 details
MGMT_HUMANORC1_HUMANBioGRID16226712 details
MGMT_HUMANDPOD1_HUMANBioGRID16226712 details
MGMT_HUMANBRCA2_HUMANBioGRID19047179 details
MGMT_HUMANDTL_HUMANBioGRID29510343 details
MGMT_HUMANUBA1_HUMANHPRD8573590 details