Entity Details

Primary name PRLR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16471
EntryNamePRLR_HUMAN
FullNameProlactin receptor
TaxID9606
Evidenceevidence at protein level
Length622
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesPRLR

GO terms

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GOName
GO:0004896 cytokine receptor activity
GO:0004923 leukemia inhibitory factor receptor activity
GO:0004925 prolactin receptor activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0006694 steroid biosynthetic process
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007566 embryo implantation
GO:0007595 lactation
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0017046 peptide hormone binding
GO:0019221 cytokine-mediated signaling pathway
GO:0019955 cytokine binding
GO:0031904 endosome lumen
GO:0038165 oncostatin-M-mediated signaling pathway
GO:0042976 activation of Janus kinase activity
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0046872 metal ion binding
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR003528 Long hematopoietin receptor, single chain, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015152 Growth hormone/erythropoietin receptor, ligand bindingDomainDomain
IPR033230 Prolactin receptorFamilyFamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00052 SomatotropinDrugbankbiotech