Entity Details

Primary name EGR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18146
EntryNameEGR1_HUMAN
FullNameEarly growth response protein 1
TaxID9606
Evidenceevidence at protein level
Length543
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesEGR1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0002931 response to ischemia
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008270 zinc ion binding
GO:0009749 response to glucose
GO:0010385 double-stranded methylated DNA binding
GO:0010628 positive regulation of gene expression
GO:0030217 T cell differentiation
GO:0030509 BMP signaling pathway
GO:0032722 positive regulation of chemokine production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0033233 regulation of protein sumoylation
GO:0035035 histone acetyltransferase binding
GO:0035914 skeletal muscle cell differentiation
GO:0042981 regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044729 hemi-methylated DNA-binding
GO:0044849 estrous cycle
GO:0045475 locomotor rhythm
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046886 positive regulation of hormone biosynthetic process
GO:0060086 circadian temperature homeostasis
GO:0060337 type I interferon signaling pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071480 cellular response to gamma radiation
GO:0071504 cellular response to heparin
GO:0071506 cellular response to mycophenolic acid
GO:0072110 glomerular mesangial cell proliferation
GO:0072303 positive regulation of glomerular metanephric mesangial cell proliferation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0098759 cellular response to interleukin-8
GO:1901216 positive regulation of neuron death
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1902949 positive regulation of tau-protein kinase activity
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding
GO:2000182 regulation of progesterone biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR021839 Early growth response protein 1, C-terminalRepeatRepeat
IPR021849 Early growth response, N-terminalDomainDomain
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
EGR1_HUMANP53_HUMANBioGRID, HPRD, MINT11251186 14744935 15225550 21325822 details
EGR1_HUMANARF_HUMANBioGRID, HPRD, MINT19057511 details
EGR1_HUMANEP300_HUMANBioGRID, HPRD, MINT15225550 20018936 20089040 9806899 details
EGR1_HUMANSRBP2_HUMANBioGRID, IntAct20936779 details
EGR1_HUMANNAB1_HUMANBioGRID, HPRD, IntAct28514442 7624335 details
EGR1_HUMANCBP_HUMANBioGRID, HPRD9806899 details
EGR1_HUMANCEBPB_HUMANBioGRID, HPRD12947119 22260630 details
EGR1_HUMANNAB2_HUMANBioGRID, HPRD8668170 details
EGR1_HUMANPITX1_HUMANBioGRID, HPRD10082522 details
EGR1_HUMANNFAC1_HUMANBioGRID12560487 details
EGR1_HUMANPSA3_HUMANBioGRID, HPRD12379479 details
EGR1_HUMANTF65_HUMANBioGRID, HPRD10671503 details
EGR1_HUMANERBB3_HUMANBioGRID12840049 details
EGR1_HUMANIL1B_HUMANBioGRID22455954 details
EGR1_HUMANSRA1_HUMANBioGRID20398657 details
EGR1_HUMANCDN2A_HUMANBioGRID19057511 details
EGR1_HUMANWT1_HUMANBioGRID19067769 details
EGR1_HUMANDNM3L_HUMANBioGRID24952347 details
EGR1_HUMANCRBN_HUMANBioGRID30385546 details
EGR1_HUMANTNR16_HUMANBioGRID18378044 details
EGR1_HUMANSUMO1_HUMANMINT19057511 details
EGR1_HUMANSNAI1_HUMANBioGRID, MINT20121949 details
EGR1_HUMANSP1_HUMANBioGRID, HPRD, MINT12569082 20121949 details
EGR1_HUMANCTNB1_HUMANBioGRID, I2D21743491 details
EGR1_HUMANPFD5_HUMANBioGRID18281035 details
EGR1_HUMANTBX2_HUMANBioGRID20348948 details
EGR1_HUMANPTEN_HUMANBioGRID21354147 details
EGR1_HUMANMDM2_HUMANBioGRID15225550 details
EGR1_HUMANNFAC2_HUMANBioGRID, HPRD12560487 27637333 details
EGR1_HUMANCIDEC_HUMANBioGRID24742676 details
EGR1_HUMANNTRK1_HUMANBioGRID18378044 details
EGR1_HUMANCSK21_HUMANHPRD8662759 details
EGR1_HUMANJUN_HUMANHPRD11278640 details