Entity Details

Primary name FILA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20930
EntryNameFILA_HUMAN
FullNameFilaggrin
TaxID9606
Evidenceevidence at protein level
Length4061
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesFLG

GO terms

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GOName
GO:0001533 cornified envelope
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0007275 multicellular organism development
GO:0018149 peptide cross-linking
GO:0030216 keratinocyte differentiation
GO:0030280 structural constituent of skin epidermis
GO:0036457 keratohyalin granule
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0046914 transition metal ion binding
GO:0061436 establishment of skin barrier
GO:0062023 collagen-containing extracellular matrix
GO:0070268 cornification

Subcellular Location

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Subcellular Location
Cytoplasmic granule

Domains

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DomainNameCategoryType
IPR001751 S100/Calbindin-D9k, conserved siteSiteConserved site
IPR002048 EF-hand domainDomainDomain
IPR003303 FilaggrinFamilyFamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013787 S100/CaBP-9k-type, calcium binding, subdomainDomainDomain
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR034325 S-100DomainDomain

Diseases

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