Entity Details

Primary name DNJB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25686
EntryNameDNJB2_HUMAN
FullNameDnaJ homolog subfamily B member 2
TaxID9606
Evidenceevidence at protein level
Length324
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesDNAJB2

GO terms

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GOName
GO:0001671 ATPase activator activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006986 response to unfolded protein
GO:0008285 negative regulation of cell population proliferation
GO:0016234 inclusion body
GO:0030308 negative regulation of cell growth
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0030544 Hsp70 protein binding
GO:0031227 intrinsic component of endoplasmic reticulum membrane
GO:0031396 regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0031965 nuclear membrane
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032781 positive regulation of ATPase activity
GO:0032880 regulation of protein localization
GO:0042026 protein refolding
GO:0042406 extrinsic component of endoplasmic reticulum membrane
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048471 perinuclear region of cytoplasm
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0061077 chaperone-mediated protein folding
GO:0070050 neuron cellular homeostasis
GO:0070628 proteasome binding
GO:0090084 negative regulation of inclusion body assembly
GO:0090086 negative regulation of protein deubiquitination
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
GO:0140036 ubiquitin-dependent protein binding
GO:1903644 regulation of chaperone-mediated protein folding

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001623 DnaJ domainDomainDomain
IPR003903 Ubiquitin interacting motifSiteConserved site
IPR018253 DnaJ domain, conserved siteSiteConserved site
IPR036869 Chaperone J-domain superfamilyFamilyHomologous superfamily
IPR043183 DnaJ homolog subfamily B member 2FamilyFamily

Diseases

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Disease IDSourceNameDescription
614881 OMIMDistal spinal muscular atrophy, autosomal recessive, 5 (DSMA5)An autosomal recessive neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and atrophy resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. Sensation and cognition are not impaired. The disease is caused by variants affecting the gene represented in this entry.