Entity Details

Primary name CP2CI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP33260
EntryNameCP2CI_HUMAN
FullNameCytochrome P450 2C18
TaxID9606
Evidenceevidence at protein level
Length490
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesCYP2C18

GO terms

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GOName
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0006082 organic acid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008392 arachidonic acid epoxygenase activity
GO:0008395 steroid hydroxylase activity
GO:0008401 retinoic acid 4-hydroxylase activity
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019373 epoxygenase P450 pathway
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042738 exogenous drug catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0070330 aromatase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00082 PegvisomantDrugbankbiotech
DB00250 DapsoneDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00338 OmeprazoleDrugbanksmall molecule
DB00349 ClobazamDrugbanksmall molecule
DB00448 LansoprazoleDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00531 CyclophosphamideDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00682 WarfarinDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00818 PropofolDrugbanksmall molecule
DB00829 DiazepamDrugbanksmall molecule
DB00850 PerphenazineDrugbanksmall molecule
DB00921 BuprenorphineDrugbanksmall molecule
DB01124 TolbutamideDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01181 IfosfamideDrugbanksmall molecule
DB01424 AminophenazoneSwissprotsmall molecule
DB01435 AntipyrineDrugbanksmall molecule
DB01559 ClotiazepamDrugbanksmall molecule
DB07670 N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamideDrugbanksmall molecule
DB08496 (R)-warfarinSwissprotsmall molecule
DB09166 EtizolamDrugbanksmall molecule
DB11757 IstradefyllineDrugbanksmall molecule
DB14055 (S)-WarfarinSwissprotsmall molecule

Interactions

5 interactions