Entity Details

Primary name PGH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35354
EntryNamePGH2_HUMAN
FullNameProstaglandin G/H synthase 2
TaxID9606
Evidenceevidence at protein level
Length604
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPTGS2

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0008217 regulation of blood pressure
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0019221 cytokine-mediated signaling pathway
GO:0019371 cyclooxygenase pathway
GO:0019372 lipoxygenase pathway
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031622 positive regulation of fever generation
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043005 neuron projection
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046872 metal ion binding
GO:0050727 regulation of inflammatory response
GO:0051213 dioxygenase activity
GO:0071456 cellular response to hypoxia
GO:0071636 positive regulation of transforming growth factor beta production
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090271 positive regulation of fibroblast growth factor production
GO:0090336 positive regulation of brown fat cell differentiation
GO:0090362 positive regulation of platelet-derived growth factor production
GO:0150077 regulation of neuroinflammatory response

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane
Nucleus inner membrane
Nucleus outer membrane

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR010255 Haem peroxidase superfamilyFamilyHomologous superfamily
IPR019791 Haem peroxidase, animal-typeFamilyFamily
IPR029576 Prostaglandin G/H synthase 2FamilyFamily
IPR037120 Haem peroxidase domain superfamily, animal typeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00035 DesmopressinDrugbanksmall molecule
DB00041 AldesleukinDrugbankbiotech
DB00154 Dihomo-gamma-linolenic acidDrugbanksmall molecule
DB00159 IcosapentDrugbanksmall molecule
DB00233 Aminosalicylic acidDrugbanksmall molecule
DB00244 MesalazineDrugbanksmall molecule
DB00250 DapsoneDrugbanksmall molecule
DB00316 AcetaminophenDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00360 SapropterinDrugbanksmall molecule
DB00461 NabumetoneDrugbanksmall molecule
DB00465 KetorolacDrugbanksmall molecule
DB00469 TenoxicamDrugbanksmall molecule
DB00480 LenalidomideDrugbanksmall molecule
DB00482 CelecoxibDrugbanksmall molecule
DB00500 TolmetinDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00533 RofecoxibDrugbanksmall molecule
DB00554 PiroxicamDrugbanksmall molecule
DB00573 FenoprofenDrugbanksmall molecule
DB00580 ValdecoxibDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00605 SulindacDrugbanksmall molecule
DB00620 TriamcinoloneDrugbanksmall molecule
DB00712 FlurbiprofenDrugbanksmall molecule
DB00720 Clodronic acidDrugbanksmall molecule
DB00749 EtodolacDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00784 Mefenamic acidDrugbanksmall molecule
DB00788 NaproxenDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB00812 PhenylbutazoneDrugbanksmall molecule
DB00814 MeloxicamDrugbanksmall molecule
DB00821 CarprofenDrugbanksmall molecule
DB00856 ChlorphenesinSwissprotsmall molecule
DB00861 DiflunisalDrugbanksmall molecule
DB00870 SuprofenDrugbanksmall molecule
DB00884 Risedronic acidDrugbanksmall molecule
DB00887 BumetanideDrugbanksmall molecule
DB00936 Salicylic acidDrugbanksmall molecule
DB00939 Meclofenamic acidDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB00963 BromfenacDrugbanksmall molecule
DB00991 OxaprozinDrugbanksmall molecule
DB01009 KetoprofenDrugbanksmall molecule
DB01014 BalsalazideDrugbanksmall molecule
DB01041 ThalidomideDrugbanksmall molecule
DB01050 IbuprofenDrugbanksmall molecule
DB01283 LumiracoxibDrugbanksmall molecule
DB01395 DrospirenoneDrugbanksmall molecule
DB01397 Magnesium salicylateDrugbanksmall molecule
DB01399 SalsalateDrugbanksmall molecule
DB01401 Choline magnesium trisalicylateDrugbanksmall molecule
DB01404 GinsengDrugbanksmall molecule
DB01419 AntrafenineDrugbanksmall molecule
DB01435 AntipyrineDrugbanksmall molecule
DB01600 Tiaprofenic acidDrugbanksmall molecule
DB01628 EtoricoxibDrugbanksmall molecule
DB02266 Flufenamic acidDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB03477 1-Phenylsulfonamide-3-Trifluoromethyl-5-ParabromophenylpyrazoleDrugbanksmall molecule
DB03866 Prostaglandin G2Drugbanksmall molecule
DB04552 Niflumic acidDrugbanksmall molecule
DB04725 LicofeloneDrugbanksmall molecule
DB04743 NimesulideDrugbanksmall molecule
DB05095 CimicoxibDrugbanksmall molecule
DB05804 Prasterone sulfateSwissprotsmall molecule
DB05875 Sar9, Met (O2)11-Substance PSwissprotsmall molecule
DB06195 SeliciclibDrugbanksmall molecule
DB06436 SemaxanibDrugbanksmall molecule
DB06725 LornoxicamDrugbanksmall molecule
DB06736 AceclofenacDrugbanksmall molecule
DB06774 CapsaicinDrugbanksmall molecule
DB06802 NepafenacDrugbanksmall molecule
DB06804 Nonoxynol-9Swissprotsmall molecule
DB08439 ParecoxibDrugbanksmall molecule
DB08819 TafluprostDrugbanksmall molecule
DB08910 PomalidomideDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09212 LoxoprofenDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09214 DexketoprofenDrugbanksmall molecule
DB09215 DroxicamDrugbanksmall molecule
DB09216 Tolfenamic acidDrugbanksmall molecule
DB09217 FirocoxibDrugbanksmall molecule
DB09285 MorniflumateDrugbanksmall molecule
DB09288 PropacetamolDrugbanksmall molecule
DB09295 TalniflumateDrugbanksmall molecule
DB11071 Phenyl salicylateDrugbanksmall molecule
DB11079 Trolamine salicylateDrugbanksmall molecule
DB11133 Omega-3 fatty acidsDrugbanksmall molecule
DB11201 Menthyl salicylateDrugbanksmall molecule
DB11323 Glycol salicylateDrugbanksmall molecule
DB11327 DipyrithioneDrugbanksmall molecule
DB11752 Bryostatin 1Drugbanksmall molecule
DB13167 AlclofenacDrugbanksmall molecule
DB13168 Omega-6 fatty acidsSwissprotsmall molecule
DB13346 BufexamacDrugbanksmall molecule
DB13501 BendazacDrugbanksmall molecule
DB13783 AcemetacinDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule