Entity Details

Primary name TGFR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP37173
EntryNameTGFR2_HUMAN
FullNameTGF-beta receptor type-2
TaxID9606
Evidenceevidence at protein level
Length567
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesTGFBR2

GO terms

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GOName
GO:0001568 blood vessel development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001947 heart looping
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002088 lens development in camera-type eye
GO:0002651 positive regulation of tolerance induction to self antigen
GO:0002663 positive regulation of B cell tolerance induction
GO:0002666 positive regulation of T cell tolerance induction
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003274 endocardial cushion fusion
GO:0003430 growth plate cartilage chondrocyte growth
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005026 transforming growth factor beta receptor activity, type II
GO:0005524 ATP binding
GO:0005539 glycosaminoglycan binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006468 protein phosphorylation
GO:0006898 receptor-mediated endocytosis
GO:0006915 apoptotic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007219 Notch signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007369 gastrulation
GO:0007420 brain development
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell population proliferation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0009897 external side of plasma membrane
GO:0010468 regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016021 integral component of membrane
GO:0017002 activin-activated receptor activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 animal organ regeneration
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0032147 activation of protein kinase activity
GO:0034713 type I transforming growth factor beta receptor binding
GO:0034714 type III transforming growth factor beta receptor binding
GO:0035162 embryonic hemopoiesis
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0043011 myeloid dendritic cell differentiation
GO:0043235 receptor complex
GO:0043415 positive regulation of skeletal muscle tissue regeneration
GO:0043627 response to estrogen
GO:0045121 membrane raft
GO:0045766 positive regulation of angiogenesis
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048185 activin binding
GO:0048545 response to steroid hormone
GO:0048565 digestive tract development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050431 transforming growth factor beta binding
GO:0051138 positive regulation of NK T cell differentiation
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060412 ventricular septum morphogenesis
GO:0060434 bronchus morphogenesis
GO:0060440 trachea formation
GO:0060443 mammary gland morphogenesis
GO:0060463 lung lobe morphogenesis
GO:0062009 secondary palate development
GO:0070723 response to cholesterol
GO:0071363 cellular response to growth factor stimulus
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905317 inferior endocardial cushion morphogenesis
GO:1990086 lens fiber cell apoptotic process
GO:1990428 miRNA transport
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation

Subcellular Location

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Subcellular Location
Cell membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015013 Transforming growth factor beta receptor 2 ectodomainDomainDomain
IPR017194 Transforming growth factor-beta receptor, type IIFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Disease IDSourceNameDescription
133239 OMIMEsophageal cancer (ESCR)A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. The disease is caused by variants affecting the gene represented in this entry.
610168 OMIMLoeys-Dietz syndrome 2 (LDS2)An aortic aneurysm syndrome with widespread systemic involvement, characterized by arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Physical findings include prominent joint laxity, easy bruising, wide and atrophic scars, velvety and translucent skin with easily visible veins, spontaneous rupture of the spleen or bowel, and catastrophic complications of pregnancy, including rupture of the gravid uterus and the arteries, either during pregnancy or in the immediate postpartum period. Some patients have craniosynostosis, exotropy, micrognathia and retrognathia, structural brain abnormalities, and intellectual deficit. The disease is caused by variants affecting the gene represented in this entry. TGFBR2 mutations Cys-460 and His-460 have been reported to be associated with thoracic aortic aneurysms and dissection (TAAD). This phenotype, also known as thoracic aortic aneurysms type 3 (AAT3), is distinguised from LDS2 by having aneurysms restricted to thoracic aorta. As individuals carrying these mutations also exhibit descending aortic disease and aneurysms of other arteries (PubMed:16027248), they have been considered as LDS2 by the OMIM resource.
614331 OMIMHereditary non-polyposis colorectal cancer 6 (HNPCC6)An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule

Interactions

146 interactions

InteractorPartnerSourcesPublicationsLink
TGFR2_HUMANTGFR1_HUMANBioGRID, DIP, HPRD11102446 11483955 19556242 19758997 21791611 23868260 25825445 7890683 8576253 details
TGFR2_HUMANIDHC_HUMANIntAct32814053 details
TGFR2_HUMANBAHD1_HUMANIntAct32814053 details
TGFR2_HUMANKLK8_HUMANIntAct32814053 details
TGFR2_HUMANMFS10_HUMANIntAct32814053 details
TGFR2_HUMANCCNB2_HUMANBioGRID, HPRD9926943 details
TGFR2_HUMANTGFR2_HUMANHPRD11163210 11279102 7890683 details
TGFR2_HUMANDAXX_HUMANBioGRID, MINT11483955 details
TGFR2_HUMANTGFB3_HUMANBioGRID, HPRD, IntAct, MINT11157754 11382746 11850637 12729750 21423151 8106553 9872992 details
TGFR2_HUMANRECO_HUMANBioGRID, IntAct21988832 details
TGFR2_HUMANSCUB3_HUMANI2D21441952 details
TGFR2_HUMANF104A_HUMANIntAct32814053 details
TGFR2_HUMANRILP_HUMANIntAct32814053 details
TGFR2_HUMANARFG3_HUMANIntAct32814053 details
TGFR2_HUMANU1SBP_HUMANIntAct32814053 details
TGFR2_HUMANRL37A_HUMANIntAct32814053 details
TGFR2_HUMANPGFRA_HUMANBioGRID, IntAct21988832 details
TGFR2_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
TGFR2_HUMANTCPZ_HUMANIntAct32814053 details
TGFR2_HUMANMYC_HUMANIntAct32814053 details
TGFR2_HUMANISY1_HUMANIntAct32814053 details
TGFR2_HUMANSUV91_HUMANIntAct32814053 details
TGFR2_HUMANAP2B1_HUMANBioGRID, HPRD12429842 details
TGFR2_HUMANTGFB1_HUMANBioGRID, HPRD, I2D, MINT11157754 20856203 20860622 21054789 21441952 7935686 8242742 8389764 details
TGFR2_HUMANTRMO_HUMANBioGRID, MINT24412244 details
TGFR2_HUMANPTN_HUMANIntAct32814053 details
TGFR2_HUMANPAIRB_HUMANIntAct32814053 details
TGFR2_HUMANCTL5_HUMANIntAct32814053 details
TGFR2_HUMANPAK1_HUMANBioGRID, HPRD15761153 details
TGFR2_HUMANA2GL_HUMANDIP23868260 details
TGFR2_HUMANELAV4_HUMANIntAct32814053 details
TGFR2_HUMANITAV_HUMANIntAct32814053 details
TGFR2_HUMANMAVS_HUMANIntAct32814053 details
TGFR2_HUMANSGMR1_HUMANIntAct32814053 details
TGFR2_HUMANLNX2_HUMANIntAct32814053 details
TGFR2_HUMANTRI43_HUMANIntAct32814053 details
TGFR2_HUMANEGLN_HUMANBioGRID, HPRD12015308 15702480 9872992 details
TGFR2_HUMANCBL_HUMANBioGRID23290524 31315051 details
TGFR2_HUMANFANCC_HUMANBioGRID, MINT24412244 details
TGFR2_HUMANSP6_HUMANIntAct19088080 32814053 details
TGFR2_HUMANT3JAM_HUMANIntAct32814053 details
TGFR2_HUMANIN80C_HUMANIntAct32814053 details
TGFR2_HUMANFSTL1_HUMANMINT20860622 details
TGFR2_HUMANRAPSN_HUMANIntAct32814053 details
TGFR2_HUMANPIGV_HUMANIntAct32814053 details
TGFR2_HUMANGOPC_HUMANBioGRID, IntAct21988832 details
TGFR2_HUMANZN510_HUMANBioGRID, MINT24412244 details
TGFR2_HUMANCADH1_HUMANIntAct32814053 details
TGFR2_HUMANWT1_HUMANIntAct32814053 details
TGFR2_HUMANPLPR1_HUMANIntAct32814053 details
TGFR2_HUMANATX3_HUMANIntAct32814053 details
TGFR2_HUMANCLUS_HUMANBioGRID, HPRD8555189 details
TGFR2_HUMANTRAF6_HUMANBioGRID18922473 26807171 details
TGFR2_HUMANNPL4_HUMANBioGRID, IntAct28443643 32814053 details
TGFR2_HUMANSTRAP_HUMANBioGRID, HPRD10757800 9856985 details
TGFR2_HUMANDD19B_HUMANIntAct32814053 details
TGFR2_HUMANPCSK7_HUMANIntAct32814053 details
TGFR2_HUMANDNSL1_HUMANIntAct32814053 details
TGFR2_HUMANSGCA_HUMANIntAct32814053 details
TGFR2_HUMANACVR1_HUMANBioGRID7890683 details
TGFR2_HUMANDYLT4_HUMANHPRD16982625 details
TGFR2_HUMANNSD3_HUMANIntAct32814053 details
TGFR2_HUMANATX1_HUMANIntAct32814053 details
TGFR2_HUMANCCNB1_HUMANBioGRID, HPRD9926943 details
TGFR2_HUMANA4_HUMANBioGRID21244100 21832049 details
TGFR2_HUMANMYNN_HUMANIntAct32814053 details
TGFR2_HUMANDPYL4_HUMANIntAct32814053 details
TGFR2_HUMANRBM5_HUMANIntAct32814053 details
TGFR2_HUMANHS90A_HUMANBioGRID18591668 22848678 details
TGFR2_HUMANTDGF1_HUMANBioGRID28126904 details
TGFR2_HUMANRHBD2_HUMANIntAct32814053 details
TGFR2_HUMANPSDE_HUMANBioGRID28443643 30745168 31685442 details
TGFR2_HUMANETS2_HUMANIntAct32814053 details
TGFR2_HUMANPPARA_HUMANIntAct32814053 details
TGFR2_HUMANUBP25_HUMANIntAct32814053 details
TGFR2_HUMANUBP2_HUMANBioGRID29490279 details
TGFR2_HUMANKC1D_HUMANIntAct32814053 details
TGFR2_HUMANNSL1_HUMANIntAct32814053 details
TGFR2_HUMANATG13_HUMANIntAct32814053 details
TGFR2_HUMANAP1S1_HUMANIntAct32814053 details
TGFR2_HUMANPSMD2_HUMANIntAct32814053 details
TGFR2_HUMANTCOF_HUMANIntAct32814053 details
TGFR2_HUMANKLRG1_HUMANIntAct32814053 details
TGFR2_HUMANTYY1_HUMANIntAct32814053 details
TGFR2_HUMANNRP1_HUMANBioGRID20675371 21186301 details
TGFR2_HUMANKAD2_HUMANIntAct32814053 details
TGFR2_HUMANHD_HUMANIntAct32814053 details
TGFR2_HUMANPP2AB_HUMANBioGRID, MINT24412244 details
TGFR2_HUMANGPM6A_HUMANIntAct32814053 details
TGFR2_HUMANKELL_HUMANIntAct32814053 details
TGFR2_HUMANSTT3A_HUMANIntAct32814053 details
TGFR2_HUMANNELL2_HUMANIntAct32814053 details
TGFR2_HUMANSNX20_HUMANIntAct32814053 details
TGFR2_HUMANTERT_HUMANBioGRID23741361 details
TGFR2_HUMANAT2A3_HUMANIntAct32814053 details
TGFR2_HUMANGNAO_HUMANIntAct32814053 details
TGFR2_HUMANCA216_HUMANIntAct32814053 details
TGFR2_HUMANSNX6_HUMANBioGRID, HPRD11279102 details
TGFR2_HUMANP85A_HUMANBioGRID, HPRD, IntAct26186194 28514442 9435577 details
TGFR2_HUMANCDC42_HUMANBioGRID15761153 details
TGFR2_HUMANTRAF4_HUMANBioGRID23973329 details
TGFR2_HUMANPML_HUMANHPRD15356634 details
TGFR2_HUMANPP16B_HUMANBioGRID15761153 details
TGFR2_HUMANTSSK1_HUMANHPRD15761153 details
TGFR2_HUMANMED12_HUMANIntAct23178117 details
TGFR2_HUMANMARH7_HUMANBioGRID, IntAct26186194 28514442 29794480 details
TGFR2_HUMANACVL1_HUMANDIP, HPRD10716993 23868260 details
TGFR2_HUMANTGFB2_HUMANBioGRID, HPRD11157754 8106553 details
TGFR2_HUMANARHG6_HUMANBioGRID, HPRD15761153 details
TGFR2_HUMANCAV1_HUMANBioGRID30745168 details
TGFR2_HUMANSH3K1_HUMANBioGRID26169354 details
TGFR2_HUMANFAF1_HUMANBioGRID28443643 details
TGFR2_HUMANSMAD3_HUMANHPRD8774881 details
TGFR2_HUMANSMUF2_HUMANBioGRID11163210 25149540 details
TGFR2_HUMANT22D1_HUMANBioGRID21791611 details
TGFR2_HUMANM3K7_HUMANBioGRID19556242 details
TGFR2_HUMANOXSR1_HUMANBioGRID15761153 details
TGFR2_HUMANRASF1_HUMANBioGRID27292796 details
TGFR2_HUMANSMAD7_HUMANBioGRID, HPRD11163210 25149540 9335507 details
TGFR2_HUMANCTNB1_HUMANBioGRID, HPRD12000714 details
TGFR2_HUMANTGBR3_HUMANBioGRID, HPRD11323414 8106553 details
TGFR2_HUMANKCNKI_HUMANBioGRID, HPRD15761153 details
TGFR2_HUMANPEG10_HUMANBioGRID15611116 details
TGFR2_HUMANZFYV9_HUMANHPRD9865696 details
TGFR2_HUMANP85B_HUMANBioGRID, HPRD, IntAct26186194 28514442 9435577 details
TGFR2_HUMANIQGA1_HUMANBioGRID23454766 details
TGFR2_HUMANSMUF1_HUMANBioGRID11278251 27048878 details
TGFR2_HUMANCD44_HUMANHPRD12145287 details
TGFR2_HUMANEIF3I_HUMANBioGRID, HPRD11781097 7566156 9813058 details
TGFR2_HUMANTGFA1_HUMANBioGRID, HPRD11278302 details
TGFR2_HUMANCDK1_HUMANHPRD9926943 details
TGFR2_HUMANOCLN_HUMANBioGRID15761153 details
TGFR2_HUMANNRP2_HUMANBioGRID21186301 details
TGFR2_HUMANSMAD4_HUMANHPRD8774881 details
TGFR2_HUMANSHC1_HUMANMINT17440088 details
TGFR2_HUMANACE2_HUMANUniProt26867007 details
TGFR2_HUMANTERA_HUMANBioGRID28443643 details
TGFR2_HUMANTGFI1_HUMANHPRD12421567 details
TGFR2_HUMANFBW1A_HUMANBioGRID28443643 details
TGFR2_HUMANOSR1_HUMANHPRD15761153 details
TGFR2_HUMANTRAP1_HUMANHPRD11278302 details
TGFR2_HUMANFBX34_HUMANBioGRID15761153 details
TGFR2_HUMANSPSB1_HUMANBioGRID26032413 details
TGFR2_HUMANUFD1_HUMANBioGRID28443643 details
TGFR2_HUMANCUL1_HUMANBioGRID28443643 details
TGFR2_HUMANARHG7_HUMANHPRD15761153 details