Entity Details

Primary name IQGA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46940
EntryNameIQGA1_HUMAN
FullNameRas GTPase-activating-like protein IQGAP1
TaxID9606
Evidenceevidence at protein level
Length1657
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesIQGAP1

GO terms

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GOName
GO:0001726 ruffle
GO:0005078 MAP-kinase scaffold activity
GO:0005095 GTPase inhibitor activity
GO:0005096 GTPase activator activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007346 regulation of mitotic cell cycle
GO:0016032 viral process
GO:0016477 cell migration
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0030667 secretory granule membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031267 small GTPase binding
GO:0032956 regulation of actin cytoskeleton organization
GO:0032991 protein-containing complex
GO:0036057 slit diaphragm
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043005 neuron projection
GO:0043312 neutrophil degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043539 protein serine/threonine kinase activator activity
GO:0044548 S100 protein binding
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0045860 positive regulation of protein kinase activity
GO:0051015 actin filament binding
GO:0051019 mitogen-activated protein kinase binding
GO:0051894 positive regulation of focal adhesion assembly
GO:0060090 molecular adaptor activity
GO:0070062 extracellular exosome
GO:0071277 cellular response to calcium ion
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0072015 glomerular visceral epithelial cell development
GO:1900006 positive regulation of dendrite development
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:1903829 positive regulation of cellular protein localization
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1990138 neuron projection extension
GO:1990776 response to angiotensin

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000048 IQ motif, EF-hand binding siteSiteBinding site
IPR000593 RasGAP protein, C-terminalDomainDomain
IPR001202 WW domainDomainDomain
IPR001715 Calponin homology domainDomainDomain
IPR001936 Ras GTPase-activating domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR023152 Ras GTPase-activating protein, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB11638 ArtenimolDrugbanksmall molecule

Interactions

92 interactions

InteractorPartnerSourcesPublicationsLink
IQGA1_HUMANCDC42_HUMANBioGRID, DIP, HPRD, IntAct, MINT12110184 12745076 12900413 15655247 17563371 18809683 21876773 26496610 27684187 31980649 8670801 8702968 8756646 8798539 9182573 9535855 details
IQGA1_HUMANTS101_HUMANBioGRID, HPRD, MINT17853893 details
IQGA1_HUMANERBB2_HUMANIntAct21724847 details
IQGA1_HUMANEGFR_HUMANBioGRID, IntAct19114553 21349850 details
IQGA1_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct11734550 12446675 16622255 22519731 22662192 27684187 details
IQGA1_HUMANPI51C_HUMANMINT23982733 details
IQGA1_HUMANRAC1_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT12110184 18809683 19079338 19961560 21451103 22519731 23982733 27173435 27684187 28007913 31980649 8670801 8702968 8756646 8798539 9535855 unassigned1312 details
IQGA1_HUMANCALM2_HUMANBioGRID, HPRD, IntAct11734550 12446675 18567582 22519731 26496610 27173435 8670801 unassigned1312 details
IQGA1_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
IQGA1_HUMANLBX1_HUMANBioGRID, IntAct32296183 details
IQGA1_HUMANPKNX2_HUMANBioGRID, IntAct32296183 details
IQGA1_HUMANOTX2_HUMANBioGRID, IntAct32296183 details
IQGA1_HUMANILF2_HUMANBioGRID, IntAct32296183 details
IQGA1_HUMANAP4AT_HUMANBioGRID, IntAct32296183 details
IQGA1_HUMANMEI4_HUMANBioGRID, IntAct32296183 details
IQGA1_HUMANBRAF_HUMANBioGRID, DIP17563371 18567582 27034005 27684187 details
IQGA1_HUMANCXCR2_HUMANIntAct21876773 details
IQGA1_HUMANAKAP5_HUMANBioGRID, HPRD12938160 details
IQGA1_HUMANCALM1_HUMANBioGRID, HPRD11734550 12446675 18567582 22519731 26496610 27173435 8670801 details
IQGA1_HUMANCALM3_HUMANBioGRID, HPRD11734550 12446675 18567582 22519731 26496610 27173435 8670801 details
IQGA1_HUMANS100B_HUMANBioGRID, HPRD12377780 details
IQGA1_HUMANCLIP1_HUMANBioGRID, HPRD12110184 details
IQGA1_HUMANEZRI_HUMANBioGRID10793131 details
IQGA1_HUMANCADH1_HUMANBioGRID10608854 25468996 details
IQGA1_HUMANVGFR2_HUMANBioGRID, HPRD15217908 19050761 details
IQGA1_HUMANMEN1_HUMANBioGRID, HPRD19079338 details
IQGA1_HUMAN1433T_HUMANBioGRID15161933 details
IQGA1_HUMANPDLI7_HUMANBioGRID25416956 details
IQGA1_HUMANUBC9_HUMANBioGRID19596686 details
IQGA1_HUMANMYL1_HUMANBioGRID18587628 details
IQGA1_HUMANPTPRM_HUMANBioGRID16380380 details
IQGA1_HUMANVASP_HUMANBioGRID21451103 details
IQGA1_HUMANMEOX2_HUMANBioGRID32296183 details
IQGA1_HUMANSUMO2_HUMANBioGRID32786267 details
IQGA1_HUMANCBP_HUMANBioGRID32238831 details
IQGA1_HUMANGRIA4_HUMANHPRD16190873 details
IQGA1_HUMANIKBB_HUMANIntAct14743216 details
IQGA1_HUMANIKKB_HUMANIntAct14743216 details
IQGA1_HUMANM3K3_HUMANIntAct14743216 details
IQGA1_HUMANNFKB2_HUMANIntAct14743216 details
IQGA1_HUMANRIPK3_HUMANIntAct14743216 details
IQGA1_HUMANSTAU1_HUMANBioGRID, HPRD, IntAct15121898 23125841 27684187 30948266 details
IQGA1_HUMANMYC_HUMANBioGRID, IntAct17353931 29467282 details
IQGA1_HUMANTR10D_HUMANIntAct17353931 details
IQGA1_HUMAN1433Z_HUMANMINT15161933 details
IQGA1_HUMANSHC1_HUMANBioGRID, MINT19380743 20075861 details
IQGA1_HUMANRN5A_HUMANMINT20875083 details
IQGA1_HUMANDIAP1_HUMANBioGRID, mbinfo17620407 24639526 details
IQGA1_HUMANPODO_HUMANIntAct22662192 details
IQGA1_HUMANPODXL_HUMANIntAct22662192 details
IQGA1_HUMANMAGI1_HUMANIntAct22662192 details
IQGA1_HUMANCD2AP_HUMANIntAct22662192 details
IQGA1_HUMANNPHN_HUMANBioGRID, HPRD, IntAct15634346 22662192 25652011 details
IQGA1_HUMANACTN4_HUMANBioGRID, IntAct22662192 26496610 details
IQGA1_HUMANACTB_HUMANBioGRID, IntAct16179592 22662192 26496610 details
IQGA1_HUMANPLCD1_HUMANMINT23982733 details
IQGA1_HUMANMYL6B_HUMANBioGRID, IntAct21428964 26496610 details
IQGA1_HUMANBCAR1_HUMANbhf-ucl28007913 details
IQGA1_HUMANKAPCA_HUMANBioGRID, HPRD12938160 details
IQGA1_HUMANPRGC1_HUMANBioGRID17050673 details
IQGA1_HUMANRPTOR_HUMANBioGRID22328503 details
IQGA1_HUMANAKT1_HUMANBioGRID22328503 details
IQGA1_HUMANNRDC_HUMANBioGRID22294699 details
IQGA1_HUMANSRC_HUMANBioGRID19050761 details
IQGA1_HUMANNSD2_HUMANBioGRID22028615 details
IQGA1_HUMANCY24B_HUMANBioGRID, HPRD16179592 details
IQGA1_HUMANMK03_HUMANBioGRID15655247 details
IQGA1_HUMANMK01_HUMANBioGRID, HPRD1497021909368021 15655247 details
IQGA1_HUMANCD44_HUMANBioGRID15655247 details
IQGA1_HUMANTGFR2_HUMANBioGRID23454766 details
IQGA1_HUMANAIMP1_HUMANBioGRID, HPRD22863883 9368021 details
IQGA1_HUMANLGR4_HUMANBioGRID24639526 details
IQGA1_HUMANLRP6_HUMANBioGRID24639526 details
IQGA1_HUMANDVL2_HUMANBioGRID24639526 details
IQGA1_HUMANMP2K1_HUMANBioGRID24639526 27684187 details
IQGA1_HUMANMP2K2_HUMANBioGRID24639526 details
IQGA1_HUMANFAK1_HUMANBioGRID24639526 details
IQGA1_HUMANWASL_HUMANBioGRID24639526 details
IQGA1_HUMANPAXI_HUMANBioGRID24639526 details
IQGA1_HUMANTERA_HUMANBioGRID23443559 28970065 details
IQGA1_HUMANABCE1_HUMANBioGRID25659154 details
IQGA1_HUMANRCC2_HUMANBioGRID25074804 details
IQGA1_HUMANU2AF2_HUMANBioGRID26641092 details
IQGA1_HUMANAHSA1_HUMANBioGRID22504172 details
IQGA1_HUMANCA131_HUMANBioGRID26472760 details
IQGA1_HUMANHECD1_HUMANBioGRID28073378 details
IQGA1_HUMANSMUF1_HUMANBioGRID28469997 details
IQGA1_HUMANBIRC3_HUMANBioGRID30948266 details
IQGA1_HUMANCXCR4_HUMANBioGRID30948266 details
IQGA1_HUMANCLIC5_HUMANHPRD10793131 details
IQGA1_HUMANAPC_HUMANHPRD15572129 details
IQGA1_HUMANACTS_HUMANHPRD9199170 details