Entity Details

Primary name GSK3A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49840
EntryNameGSK3A_HUMAN
FullNameGlycogen synthase kinase-3 alpha
TaxID9606
Evidenceevidence at protein level
Length483
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesGSK3A

GO terms

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GOName
GO:0003073 regulation of systemic arterial blood pressure
GO:0003214 cardiac left ventricle morphogenesis
GO:0004674 protein serine/threonine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005977 glycogen metabolic process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007212 dopamine receptor signaling pathway
GO:0007399 nervous system development
GO:0007568 aging
GO:0008286 insulin receptor signaling pathway
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010905 negative regulation of UDP-glucose catabolic process
GO:0010975 regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030424 axon
GO:0030877 beta-catenin destruction complex
GO:0031398 positive regulation of protein ubiquitination
GO:0032007 negative regulation of TOR signaling
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034236 protein kinase A catalytic subunit binding
GO:0036016 cellular response to interleukin-3
GO:0036498 IRE1-mediated unfolded protein response
GO:0043025 neuronal cell body
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0044027 hypermethylation of CpG island
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045732 positive regulation of protein catabolic process
GO:0045823 positive regulation of heart contraction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048156 tau protein binding
GO:0050321 tau-protein kinase activity
GO:0060079 excitatory postsynaptic potential
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0071285 cellular response to lithium ion
GO:0071879 positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097440 apical dendrite
GO:0098794 postsynapse
GO:0106071 positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902004 positive regulation of amyloid-beta formation
GO:1903146 regulation of autophagy of mitochondrion
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904227 negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
GO:1990635 proximal dendrite
GO:2000077 negative regulation of type B pancreatic cell development
GO:2000171 negative regulation of dendrite development
GO:2000466 negative regulation of glycogen (starch) synthase activity
GO:2000467 positive regulation of glycogen (starch) synthase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR039192 Glycogen synthase kinase 3, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

89 interactions

InteractorPartnerSourcesPublicationsLink
GSK3A_HUMANTAU_HUMANBioGRID, DIP, HPRD, UniProt16446437 17045592 26618561 7706316 7931292 details
GSK3A_HUMANGSKIP_HUMANBioGRID, IntAct20368287 23602568 27684187 details
GSK3A_HUMANSPG21_HUMANBioGRID, IntAct20368287 details
GSK3A_HUMANDEAF1_HUMANBioGRID, IntAct, UniProt20368287 30824926 details
GSK3A_HUMANNBR1_HUMANBioGRID, IntAct, UniProt20368287 24879152 30824926 details
GSK3A_HUMANAXIN2_HUMANBioGRID, IntAct, UniProt23602568 30824926 details
GSK3A_HUMANHS90B_HUMANBioGRID, IntAct, UniProt22939624 30824926 details
GSK3A_HUMANLRP6_HUMANbhf-ucl, BioGRID, UniProt16365045 30824926 details
GSK3A_HUMANZDH17_HUMANBioGRID, IntAct24705354 details
GSK3A_HUMANCTNB1_HUMANbhf-ucl, BioGRID17510365 25897075 26496610 27684187 details
GSK3A_HUMANFBX42_HUMANBioGRID, IntAct, UniProt28514442 30824926 details
GSK3A_HUMANAKA11_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANALKB3_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANAP3D1_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANAKIP_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANBCCIP_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANCK098_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANCC174_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANCHTOP_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANCNTRB_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANDCAF8_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANDCP1B_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANDDI1_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANDNJB1_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANDRC1_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANGOG6C_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANH2AV_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANHEM3_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANHMGN1_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANHNRPM_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANHS90A_HUMANBioGRID, UniProt22939624 30824926 details
GSK3A_HUMANLDHA_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANL37A2_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANMAEA_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANMTCH1_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANML12A_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANPSMD8_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANPTMA_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANRL15_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANRL19_HUMANBioGRID, UniProt27684187 30824926 details
GSK3A_HUMANRL29_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANRS15_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANRS19_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANRUNX1_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANSBNO1_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANSMCA5_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANSMG7_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANSUGP2_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANTTC16_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANUBF1_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANVCIP1_HUMANBioGRID, UniProt30824926 details
GSK3A_HUMANHD_HUMANIntAct32814053 details
GSK3A_HUMANMYC_HUMANBioGRID14563837 details
GSK3A_HUMANAKT1_HUMANBioGRID, HPRD11035810 11509608 11546794 11884598 14645548 14701753 15678105 16998585 17505062 19995607 21775285 22504172 29464284 8524413 details
GSK3A_HUMANEBP2_HUMANBioGRID21220517 details
GSK3A_HUMANGLI3_HUMANBioGRID16371461 details
GSK3A_HUMANCREB1_HUMANBioGRID14635195 details
GSK3A_HUMANKAPCA_HUMANBioGRID, HPRD11035810 11749387 11884598 12054501 details
GSK3A_HUMANPRKDC_HUMANBioGRID15678105 details
GSK3A_HUMANKPCA_HUMANBioGRID, HPRD11035810 11749387 11884598 12054501 details
GSK3A_HUMANKPCB_HUMANBioGRID, HPRD11035810 11749387 11884598 12054501 details
GSK3A_HUMANKPCG_HUMANBioGRID, HPRD11035810 11749387 11884598 12054501 details
GSK3A_HUMANKPCL_HUMANBioGRID11884598 details
GSK3A_HUMANKPCD_HUMANBioGRID, HPRD11035810 11749387 11884598 12054501 details
GSK3A_HUMANF193B_HUMANBioGRID20368287 details
GSK3A_HUMANRICTR_HUMANBioGRID25897075 details
GSK3A_HUMANB2CL1_HUMANBioGRID22617334 details
GSK3A_HUMANMCL1_HUMANBioGRID, HPRD16543145 17387146 details
GSK3A_HUMANSTAT2_HUMANBioGRID31843895 details
GSK3A_HUMANGSK3A_HUMANBioGRID, HPRD17192257 31843895 details
GSK3A_HUMANML12B_HUMANBioGRID30824926 details
GSK3A_HUMANOGT1_HUMANBioGRID32994395 details
GSK3A_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 27684187 28514442 details
GSK3A_HUMANAXIN1_HUMANbhf-ucl, BioGRID, IntAct, MINT17318175 17510365 19131971 23602568 23959799 26496610 26912724 27684187 details
GSK3A_HUMANFRAT1_HUMANBioGRID, IntAct10481074 23602568 26496610 details
GSK3A_HUMANANDR_HUMANBioGRID15361837 details
GSK3A_HUMANHDAC6_HUMANBioGRID22022450 details
GSK3A_HUMANFOXM1_HUMANBioGRID26912724 details
GSK3A_HUMANPAXI_HUMANBioGRID, HPRD16537926 27684187 details
GSK3A_HUMANPIN1_HUMANBioGRID26445356 details
GSK3A_HUMANEI2BE_HUMANHPRD11500362 15302935 9468292 details
GSK3A_HUMANKPCD3_HUMANHPRD11035810 11749387 11884598 12054501 details
GSK3A_HUMANSGK3_HUMANHPRD11035810 11749387 11884598 12054501 16543730 details
GSK3A_HUMANLRSM1_HUMANHPRD14635195 details
GSK3A_HUMANBCL3_HUMANHPRD15469820 details
GSK3A_HUMANKPCZ_HUMANHPRD11481324 details
GSK3A_HUMANCREM_HUMANHPRD8404858 details
GSK3A_HUMANHSF1_HUMANHPRD12665592 details
GSK3A_HUMANSGK1_HUMANHPRD16543730 details