Entity Details

Primary name CNBP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62633
EntryNameCNBP_HUMAN
FullNameCellular nucleic acid-binding protein
TaxID9606
Evidenceevidence at protein level
Length177
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesCNBP

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0003729 mRNA binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0042632 cholesterol homeostasis
GO:0045182 translation regulator activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051880 G-quadruplex DNA binding
GO:0071919 G-quadruplex DNA formation
GO:2000767 positive regulation of cytoplasmic translation

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

Show/Hide Table
DomainNameCategoryType
IPR001878 Zinc finger, CCHC-typeDomainDomain
IPR036875 Zinc finger, CCHC-type superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
602668 OMIMDystrophia myotonica 2 (DM2)A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases. The disease is caused by variants affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.