Entity Details

Primary name FKB1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62942
EntryNameFKB1A_HUMAN
FullNamePeptidyl-prolyl cis-trans isomerase FKBP1A
TaxID9606
Evidenceevidence at protein level
Length108
SequenceStatuscomplete
DateCreated2004-08-31
DateModified2021-06-02

Ontological Relatives

GenesFKBP1A

GO terms

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GOName
GO:0000413 protein peptidyl-prolyl isomerization
GO:0003007 heart morphogenesis
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005527 macrolide binding
GO:0005528 FK506 binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006457 protein folding
GO:0006458 'de novo' protein folding
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0014802 terminal cisterna
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0022417 protein maturation by protein folding
GO:0030018 Z disc
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031312 extrinsic component of organelle membrane
GO:0031398 positive regulation of protein ubiquitination
GO:0032092 positive regulation of protein binding
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032880 regulation of protein localization
GO:0032925 regulation of activin receptor signaling pathway
GO:0034713 type I transforming growth factor beta receptor binding
GO:0042026 protein refolding
GO:0042110 T cell activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044325 transmembrane transporter binding
GO:0046332 SMAD binding
GO:0048185 activin binding
GO:0050776 regulation of immune response
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060347 heart trabecula formation
GO:0061077 chaperone-mediated protein folding
GO:0070588 calcium ion transmembrane transport
GO:0097435 supramolecular fiber organization
GO:0098562 cytoplasmic side of membrane
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1990000 amyloid fibril formation
GO:1990425 ryanodine receptor complex

Subcellular Location

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Subcellular Location
Cytoplasm
Sarcoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00337 PimecrolimusDrugbanksmall molecule
DB00864 TacrolimusDrugbanksmall molecule
DB00877 SirolimusDrugbanksmall molecule
DB01712 (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl esterDrugbanksmall molecule
DB01723 {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic AcidDrugbanksmall molecule
DB01951 Gpi-1046Drugbanksmall molecule
DB02311 Methyl Methylsulfinylmethyl SulfideDrugbanksmall molecule
DB02888 FKB-001Drugbanksmall molecule
DB03338 Heptyl glucosideDrugbanksmall molecule
DB03621 L-709,587Drugbanksmall molecule
DB04012 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-LeucineDrugbanksmall molecule
DB04094 4-hydroxybutan-2-oneDrugbanksmall molecule
DB05814 GPI-1485Drugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB08520 (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANEDrugbanksmall molecule
DB08597 DorsomorphinDrugbanksmall molecule

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
FKB1A_HUMANRYR1_HUMANBioGRID, DIP, HPRD11171121 11237759 11279144 12704193 18268335 details
FKB1A_HUMANTRI18_HUMANBioGRID25416956 32296183 details
FKB1A_HUMANTGFR1_HUMANBioGRID, HPRD, IntAct10025408 16049346 24658140 7518616 7791754 9346894 details
FKB1A_HUMANRYR3_HUMANBioGRID, HPRD11171121 11598113 details
FKB1A_HUMANAHSP_HUMANBioGRID, IntAct25416956 details
FKB1A_HUMANMTOR_HUMANBioGRID, DIP, HPRD, IntAct, MINT10089303 15268862 15284440 15467718 15796538 17148612 17991864 20639890 20851351 22664266 26344197 29997244 32131492 7822316 8662507 details
FKB1A_HUMANGLMN_HUMANBioGRID, HPRD11164950 31490997 8955134 details
FKB1A_HUMANTGFB1_HUMANBioGRID11960000 23734213 details
FKB1A_HUMANFKBP4_HUMANHPRD11164950 details
FKB1A_HUMANBARD1_HUMANBioGRID22990118 details
FKB1A_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
FKB1A_HUMANTYY1_HUMANBioGRID, HPRD7541038 details
FKB1A_HUMANHS90A_HUMANBioGRID30382094 details
FKB1A_HUMANERBB4_HUMANBioGRID, IntAct31980649 details
FKB1A_HUMANSMAD7_HUMANbhf-ucl, BioGRID16720724 details
FKB1A_HUMANABI2_HUMANBioGRID32296183 details
FKB1A_HUMANERBB3_HUMANBioGRID, IntAct31980649 details
FKB1A_HUMANBMR1A_HUMANBioGRID9663660 details
FKB1A_HUMANACVL1_HUMANBioGRID19592636 details
FKB1A_HUMANSMAD6_HUMANbhf-ucl16720724 details
FKB1A_HUMANSF3B4_HUMANBioGRID25416956 details
FKB1A_HUMANTAU_HUMANBioGRID30382094 details
FKB1A_HUMANNLGN3_HUMANBioGRID, IntAct25464930 details
FKB1A_HUMANDYR_HUMANBioGRID, HPRD12812497 details
FKB1A_HUMANACV1B_HUMANbhf-ucl, BioGRID15908921 16720724 details
FKB1A_HUMANITPR1_HUMANBioGRID, HPRD16278292 9346894 details
FKB1A_HUMANMDM2_HUMANBioGRID27617579 details
FKB1A_HUMANCDC42_HUMANBioGRID31478661 details
FKB1A_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
FKB1A_HUMANRYR2_HUMANHPIDb11237759 details
FKB1A_HUMANFKB1A_HUMANBioGRID, HPRD10852943 11438723 8521476 8662507 9346894 9871618 details
FKB1A_HUMANTRPC3_HUMANBioGRID, HPRD15199065 details
FKB1A_HUMANPP2BA_HUMANHPRD7543369 8524402 details
FKB1A_HUMANACVR1_HUMANBioGRID22977237 details
FKB1A_HUMANTRPC7_HUMANBioGRID15199065 details
FKB1A_HUMANDCA16_HUMANBioGRID31209349 details
FKB1A_HUMANVHL_HUMANIntAct17353931 details
FKB1A_HUMANRPTOR_HUMANBioGRID15268862 15467718 details
FKB1A_HUMANEPB41_HUMANIntAct17353931 details
FKB1A_HUMANTRPC6_HUMANBioGRID15199065 details
FKB1A_HUMANTGFI1_HUMANHPRD12417722 details