Entity Details

Primary name SKP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP63208
EntryNameSKP1_HUMAN
FullNameS-phase kinase-associated protein 1
TaxID9606
Evidenceevidence at protein level
Length163
SequenceStatuscomplete
DateCreated2004-09-27
DateModified2021-06-02

Ontological Relatives

GenesSKP1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006879 cellular iron ion homeostasis
GO:0008013 beta-catenin binding
GO:0010265 SCF complex assembly
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016032 viral process
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0019005 SCF ubiquitin ligase complex
GO:0019904 protein domain specific binding
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031467 Cul7-RING ubiquitin ligase complex
GO:0035518 histone H2A monoubiquitination
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:0051457 maintenance of protein location in nucleus
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070936 protein K48-linked ubiquitination
GO:0097602 cullin family protein binding
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1904668 positive regulation of ubiquitin protein ligase activity
GO:1990444 F-box domain binding
GO:1990756 ubiquitin ligase-substrate adaptor activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001232 S-phase kinase-associated protein 1-likeFamilyFamily
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR016072 SKP1 component, dimerisationDomainDomain
IPR016073 SKP1 component, POZ domainDomainDomain
IPR016897 S-phase kinase-associated protein 1FamilyFamily
IPR036296 SKP1-like, dimerisation domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01750 1-naphthaleneacetic acidDrugbanksmall molecule
DB06980 (2S)-2-(1H-indol-3-yl)hexanoic acidDrugbanksmall molecule
DB06981 (2S)-2-(1H-indol-3-yl)pentanoic acidDrugbanksmall molecule
DB06982 (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acidDrugbanksmall molecule
DB07950 Indoleacetic acidDrugbanksmall molecule

Interactions

179 interactions

InteractorPartnerSourcesPublicationsLink
SKP1_HUMANFBW1A_HUMANBioGRID, DIP, HPRD, IntAct, MINT10023660 10074433 10228155 10514433 10531035 10644755 10918611 11483504 12609982 12820959 14706645 15070733 15536641 16275325 17215248 17283138 19061640 19159283 19933270 20596027 22388891 22632967 23607312 24469040 24811168 24912152 25332235 25416956 25632159 25900982 26474281 27705803 28614300 29863914 29997244 30254149 30267325 30728155 31210753 31467278 32350066 9660940 9990852 details
SKP1_HUMANFBW1B_HUMANbhf-ucl, BioGRID, DIP, IntAct, MINT10230406 10321728 10644755 12165731 15070733 17510365 19159283 19615732 20596027 21145461 24500709 25332235 25515538 25609649 25900982 26496610 27705803 29150431 29435596 30254149 32350066 details
SKP1_HUMANIKBA_HUMANBioGRID, HPRD, IntAct10066435 10230406 10514433 14743216 22590978 24912152 29499133 9990852 details
SKP1_HUMANCUL1_HUMANBioGRID, DIP, HPRD, InnateDB, IntAct, MINT10023660 10230406 10230407 10648623 10713156 11027288 11961546 12504025 12504026 12609982 12628165 12684064 12904573 14685242 15452136 15966899 16357137 16759355 17290223 18094045 18818696 19270694 19933270 19945379 20832730 21145461 21169563 21249194 21778237 22474075 22660580 22767593 23324393 23770852 23951410 26474281 26540345 26725323 26753747 26976582 27697867 27705803 28007894 28152074 29070679 29103612 29499133 29863914 30653357 32249768 32313199 9430629 9636170 9663463 9736735 9827542 9990852 details
SKP1_HUMANSKP2_HUMANBioGRID, DIP, HPRD, IntAct, MINT10531035 10559858 10559916 10918611 11099048 11961546 12609982 12813041 15070733 15342634 15452136 15456869 15469821 16275325 16376880 16880511 18239684 18667692 18818696 19270694 19398581 20041211 20160477 22310285 22464731 22524983 22632967 23261596 23770852 23868976 23911321 24085301 26087183 26474281 27220724 27705803 28614300 29137415 29499133 29997244 30254149 30728155 31467278 32350066 9430629 9827542 details
SKP1_HUMANRBX1_HUMANBioGRID, HPRD, IntAct10531037 11245432 11961546 12481031 12504025 12628165 12684064 12813041 12840033 15452136 16357137 23770852 26540345 27705803 29499133 29507117 29863914 30349055 details
SKP1_HUMANCKS1_HUMANBioGRID, IntAct12813041 15772084 16209941 16979657 19786724 23589337 27705803 details
SKP1_HUMANFBX34_HUMANBioGRID, HPRD, IntAct16169070 26087183 details
SKP1_HUMANDD19B_HUMANHPRD, IntAct16169070 details
SKP1_HUMANCDN1A_HUMANBioGRID, IntAct, MINT16376880 25241761 27215384 details
SKP1_HUMANFBXW2_HUMANBioGRID, DIP, HPRD, IntAct10531035 10531037 11238952 15070733 19398581 20596027 22388891 22632967 26087183 27705803 31210753 32350066 details
SKP1_HUMANFBXW5_HUMANBioGRID, DIP, HPRD, IntAct10531037 15070733 19159283 20596027 22388891 22632967 23314863 23319600 26087183 27705803 30596474 31210753 32350066 details
SKP1_HUMANFBXW8_HUMANBioGRID, DIP, HPRD, IntAct10531037 12481031 15070733 17205132 18498745 20596027 21572988 21946088 22388891 26087183 27705803 31343991 details
SKP1_HUMANFBXW7_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11565034 11585921 12628165 15070733 17434132 19412162 20596027 21205095 21620836 22388891 22524983 22632967 23791182 24811168 25720964 26087183 26474281 26540345 26976582 27247421 28007894 28522751 28614300 29346117 29408378 30728155 31210753 31285543 32086376 32350066 details
SKP1_HUMANCTNB1_HUMANBioGRID, IntAct11389839 12820959 18805092 21466614 25241761 27684187 9990852 details
SKP1_HUMANFBX25_HUMANBioGRID, HPRD, IntAct16278047 16714087 20473970 32296183 details
SKP1_HUMANFBX4_HUMANBioGRID, HPRD, I2D, IntAct10531035 16278047 17353931 20181953 21242966 24019069 26087183 27705803 28514442 29142209 31130363 31210753 32296183 details
SKP1_HUMANFBX7_HUMANBioGRID, DIP, HPRD, IntAct10531035 10531037 15145941 16278047 20596027 21378169 22632967 24947323 25416956 26496610 27497298 27503909 27705803 28514442 details
SKP1_HUMANFBX11_HUMANBioGRID, DIP, IntAct17098746 20596027 22113614 22632967 23478441 25416956 27705803 28614300 29892012 30254149 31515488 details
SKP1_HUMANPP1A_HUMANBioGRID, HPRD, IntAct17274640 details
SKP1_HUMANPP1G_HUMANBioGRID, IntAct17274640 details
SKP1_HUMANMYC_HUMANBioGRID, IntAct12963825 17314511 21988832 29467282 30415952 details
SKP1_HUMANFBX5_HUMANBioGRID, HPRD, IntAct, MINT10531035 17380122 17463251 27705803 31130363 31257023 32296183 details
SKP1_HUMANFXL12_HUMANBioGRID, IntAct, MINT18660753 23324393 26124079 27215384 27705803 31257023 32296183 details
SKP1_HUMANFBXL8_HUMANBioGRID, HPRD, IntAct10531037 19159283 25416956 26496610 27705803 32296183 details
SKP1_HUMANFBX44_HUMANBioGRID, HPRD, IntAct10531035 17215248 18203720 19159283 20057081 21640084 25416956 25970626 26186194 26460611 27705803 28514442 32296183 details
SKP1_HUMANFBXL2_HUMANBioGRID, HPRD, IntAct, MINT10508920 10531037 19159283 22399757 23604317 26790640 27705803 28614300 32296183 details
SKP1_HUMANCDCA3_HUMANBioGRID, HPRD, IntAct12679038 15070733 19159283 details
SKP1_HUMANFBXL6_HUMANBioGRID, IntAct19159283 26344197 27705803 32576198 details
SKP1_HUMANFBXW9_HUMANBioGRID, IntAct19159283 27705803 30596474 details
SKP1_HUMANFBX46_HUMANBioGRID, DIP, IntAct19159283 20596027 22632967 23658844 27705803 32296183 details
SKP1_HUMANSGT1_HUMANBioGRID, HPRD, MINT12746458 16501598 18818696 26344197 details
SKP1_HUMANHS90B_HUMANMINT18818696 details
SKP1_HUMANFBXL5_HUMANBioGRID, HPRD, IntAct, MINT10531037 19762596 19762597 21516116 24157836 24778179 25416956 27383304 28514442 31167929 32126207 32296183 details
SKP1_HUMANFBX3_HUMANBioGRID, DIP, HPRD, IntAct, MINT10531037 18809579 20596027 21516116 22632967 27705803 28561026 31130363 31257023 31515488 32296183 32891887 details
SKP1_HUMANCDK4_HUMANBioGRID, IntAct21988832 details
SKP1_HUMANKDM2B_HUMANBioGRID, IntAct, MINT, UniProt16943429 17463251 17704768 24981860 25533466 26725323 27705803 28614300 30033217 30596474 details
SKP1_HUMANFXL15_HUMANBioGRID, IntAct, MINT17463251 19159283 21572392 26186194 27705803 28514442 30596474 32350066 details
SKP1_HUMANFBX32_HUMANBioGRID, HPRD, IntAct11717410 23414517 26753747 details
SKP1_HUMANLTOR5_HUMANBioGRID, IntAct23414517 details
SKP1_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
SKP1_HUMANFBX28_HUMANBioGRID, DIP, IntAct20596027 22632967 25416956 27705803 27754753 32296183 32814053 details
SKP1_HUMANFBX9_HUMANBioGRID, DIP, HPRD, IntAct10531035 17463251 20596027 22632967 27705803 32296183 details
SKP1_HUMANCDK2_HUMANBioGRID, IntAct16979657 23602568 25852190 26496610 7553852 9636170 details
SKP1_HUMANCAND1_HUMANBioGRID, IntAct12504026 21145461 29499133 details
SKP1_HUMANCYBP_HUMANBioGRID, HPRD, IntAct11389839 22295074 25241761 27099442 28196083 29099417 details
SKP1_HUMANCDN1B_HUMANBioGRID, IntAct10559916 16209941 23910095 details
SKP1_HUMANFXL14_HUMANBioGRID, IntAct27705803 28514442 32296183 details
SKP1_HUMANMTUS1_HUMANBioGRID, IntAct27705803 32296183 details
SKP1_HUMANFBH1_HUMANBioGRID, HPRD, IntAct11956208 15118074 23319600 27705803 30596474 31130363 details
SKP1_HUMANFBX6_HUMANBioGRID, HPRD, IntAct10531035 17215248 17494702 18203720 21640084 22268729 26087183 27705803 29499133 30833792 31130363 31210753 32296183 details
SKP1_HUMANFBXL4_HUMANBioGRID, HPRD, IntAct10531037 27705803 32877691 details
SKP1_HUMANFBSP1_HUMANBioGRID, IntAct19398581 24992930 25143387 27705803 29997255 details
SKP1_HUMANFXL20_HUMANBioGRID, IntAct27705803 32296183 details
SKP1_HUMANFBX2_HUMANBioGRID, HPRD, IntAct10531035 10531037 15109709 17389369 17494702 18203720 18284940 19159283 25416956 27705803 31210753 32296183 9857061 details
SKP1_HUMANFBX17_HUMANBioGRID, HPRD, IntAct10531037 18203720 21640084 25416956 26186194 27705803 28514442 32296183 details
SKP1_HUMANCUL7_HUMANBioGRID, HPRD, IntAct10531037 12481031 17998335 23045529 27705803 31343991 details
SKP1_HUMANFBX22_HUMANBioGRID, IntAct17463251 26087183 26496610 27705803 29945959 30596474 31130363 31217475 31257023 32249768 32296183 details
SKP1_HUMANRBTN2_HUMANBioGRID, IntAct25416956 details
SKP1_HUMANTTC9C_HUMANBioGRID, IntAct25416956 26496610 32296183 details
SKP1_HUMANMTNB_HUMANBioGRID, IntAct25416956 details
SKP1_HUMANKCTD9_HUMANBioGRID, IntAct25416956 details
SKP1_HUMANA26L1_HUMANIntAct25416956 details
SKP1_HUMANFBX48_HUMANBioGRID, IntAct32296183 details
SKP1_HUMANFBX27_HUMANBioGRID, IntAct18203720 21640084 32296183 details
SKP1_HUMANFBX43_HUMANBioGRID, IntAct32296183 details
SKP1_HUMANFXL22_HUMANBioGRID, IntAct22972877 32296183 details
SKP1_HUMANMED21_HUMANBioGRID, DIP22479149 details
SKP1_HUMANFBXL3_HUMANBioGRID, DIP, HPRD10531035 23503662 24085301 28614300 30596474 32350066 details
SKP1_HUMANATX1_HUMANBioGRID, IntAct, UniProt25959826 32814053 details
SKP1_HUMANSPRE1_HUMANIntAct32814053 details
SKP1_HUMANCDK9_HUMANBioGRID11689688 details
SKP1_HUMANTBL1X_HUMANBioGRID, HPRD11389839 details
SKP1_HUMANNIPA_HUMANBioGRID16009132 17389604 22205987 26474281 28115489 details
SKP1_HUMANTERF1_HUMANBioGRID20181953 details
SKP1_HUMANFBX8_HUMANBioGRID, HPRD10531037 18094045 details
SKP1_HUMANHS90A_HUMANBioGRID18818696 details
SKP1_HUMANCENPE_HUMANBioGRID, HPRD16682006 details
SKP1_HUMANGLMN_HUMANBioGRID22405651 details
SKP1_HUMANTRRAP_HUMANBioGRID19066453 details
SKP1_HUMANUB2D1_HUMANBioGRID10973499 17081987 details
SKP1_HUMANGHR_HUMANBioGRID23607312 25505247 details
SKP1_HUMANTT21A_HUMANBioGRID25416956 details
SKP1_HUMANPTEN_HUMANBioGRID26561776 32249768 details
SKP1_HUMANPRGC1_HUMANBioGRID26407237 details
SKP1_HUMANSC23B_HUMANBioGRID30596474 details
SKP1_HUMANMEOX2_HUMANBioGRID32296183 details
SKP1_HUMANCFLAR_HUMANBioGRID32313199 details
SKP1_HUMANSKP1_HUMANHPRD10531037 11961546 details
SKP1_HUMANIKBB_HUMANHPRD, IntAct14743216 details
SKP1_HUMANIKBE_HUMANHPRD, IntAct14743216 details
SKP1_HUMANFBXL7_HUMANBioGRID, IntAct15070733 17704768 25654763 28614300 details
SKP1_HUMANFBX41_HUMANIntAct15070733 details
SKP1_HUMANKDM2A_HUMANBioGRID, IntAct, MINT15070733 17463251 24981860 27705803 30033217 details
SKP1_HUMANFBX33_HUMANBioGRID, IntAct, MINT16797541 27705803 details
SKP1_HUMANYBOX1_HUMANMINT16797541 details
SKP1_HUMANFAF1_HUMANBioGRID, IntAct18775313 22730322 details
SKP1_HUMANPCGF1_HUMANBioGRID, IntAct, UniProt16943429 22325352 24981860 26687479 27505670 27705803 details
SKP1_HUMANCCNF_HUMANBioGRID, DIP, IntAct17215248 20596027 21640084 22632967 28614300 28954236 30254149 31130363 31577344 details
SKP1_HUMANFBX31_HUMANBioGRID, DIP, IntAct16357137 19412162 22632967 23469015 27568981 29279382 details
SKP1_HUMANFBXW4_HUMANBioGRID, DIP, IntAct20596027 22388891 22632967 23658844 27705803 details
SKP1_HUMANCUL4A_HUMANBioGRID, IntAct21145461 22474075 details
SKP1_HUMANNEDD8_HUMANBioGRID, IntAct16503656 21145461 27705803 details
SKP1_HUMANCCNA2_HUMANBioGRID, HPRD, IntAct16209941 26496610 9858587 details
SKP1_HUMANFBX42_HUMANBioGRID, IntAct19509332 27705803 28514442 31549767 details
SKP1_HUMANMYCB2_HUMANBioGRID, IntAct27705803 29997255 details
SKP1_HUMANFBX30_HUMANBioGRID, IntAct26087183 26496610 27705803 31210753 details
SKP1_HUMANFBX38_HUMANBioGRID, IntAct27705803 30804394 details
SKP1_HUMANPSA2_HUMANBioGRID, IntAct19193609 27705803 details
SKP1_HUMANFXL17_HUMANBioGRID, IntAct24035498 27234298 27705803 30190310 31257023 31560077 details
SKP1_HUMANFBX21_HUMANBioGRID, IntAct26631746 27705803 31130363 details
SKP1_HUMANFXL19_HUMANBioGRID, IntAct, MINT22660580 24981860 27705803 28614300 details
SKP1_HUMANCCD22_HUMANBioGRID, UniProt23563313 details
SKP1_HUMANDCAF7_HUMANBioGRID, IntAct27173435 unassigned1312 details
SKP1_HUMANDYL2_HUMANBioGRID, IntAct27173435 unassigned1312 details
SKP1_HUMANMPIP1_HUMANBioGRID, IntAct12234927 14603323 14752276 15536641 27432908 28330616 details
SKP1_HUMANESR1_HUMANBioGRID, IntAct23770852 31527615 details
SKP1_HUMANSYUA_HUMANBioGRID, IntAct31167929 31980649 details
SKP1_HUMANETV6_HUMANBioGRID18426905 details
SKP1_HUMANBORA_HUMANBioGRID18378770 details
SKP1_HUMANRO52_HUMANBioGRID16880511 details
SKP1_HUMANGCM1_HUMANBioGRID15640526 details
SKP1_HUMANRBL2_HUMANBioGRID12717421 details
SKP1_HUMANRU17_HUMANBioGRID11850407 details
SKP1_HUMANRASF1_HUMANBioGRID18071316 details
SKP1_HUMANCCND1_HUMANBioGRID17081987 17205132 details
SKP1_HUMANMED6_HUMANBioGRID22479149 details
SKP1_HUMANCCNG2_HUMANBioGRID18784254 details
SKP1_HUMANEF2K_HUMANBioGRID22669845 details
SKP1_HUMANCXB2_HUMANBioGRID15109709 details
SKP1_HUMANPML_HUMANBioGRID18809579 details
SKP1_HUMANUBP37_HUMANBioGRID23027877 26299517 details
SKP1_HUMANBTG1_HUMANBioGRID22975506 details
SKP1_HUMANBTG2_HUMANBioGRID22975506 details
SKP1_HUMANMAGAB_HUMANBioGRID19828458 details
SKP1_HUMANBRCA1_HUMANBioGRID23086937 details
SKP1_HUMANKLC1_HUMANBioGRID21915095 details
SKP1_HUMANSCNND_HUMANBioGRID23589227 details
SKP1_HUMANSF3B3_HUMANBioGRID23951410 details
SKP1_HUMANMTSS1_HUMANBioGRID24318128 details
SKP1_HUMANNEDD4_HUMANBioGRID24657926 details
SKP1_HUMANM4K1_HUMANBioGRID24362026 details
SKP1_HUMANNUAK1_HUMANBioGRID24785407 details
SKP1_HUMANDAB2P_HUMANBioGRID24912918 details
SKP1_HUMANCADH2_HUMANBioGRID25143387 details
SKP1_HUMANSOSB1_HUMANBioGRID25249620 details
SKP1_HUMANCSN1_HUMANBioGRID, HPRD11337588 details
SKP1_HUMANGATA2_HUMANBioGRID25670854 details
SKP1_HUMANHEY1_HUMANBioGRID26068074 details
SKP1_HUMANFBW12_HUMANBioGRID26171402 details
SKP1_HUMANFBX24_HUMANBioGRID25582197 details
SKP1_HUMANMAGC2_HUMANBioGRID26540345 details
SKP1_HUMANFBX36_HUMANBioGRID26087183 details
SKP1_HUMANARI1A_HUMANBioGRID26400522 details
SKP1_HUMANDRG2_HUMANBioGRID22450327 details
SKP1_HUMANSLBP_HUMANBioGRID27773672 details
SKP1_HUMANMCL1_HUMANBioGRID28522751 28776569 details
SKP1_HUMANPCBP1_HUMANBioGRID28963376 details
SKP1_HUMANFXR1_HUMANBioGRID29142209 details
SKP1_HUMANKMT5A_HUMANBioGRID26666832 details
SKP1_HUMANANM1_HUMANBioGRID28883095 details
SKP1_HUMANPTC1_HUMANBioGRID26885983 details
SKP1_HUMANHES1_HUMANBioGRID29070679 details
SKP1_HUMANPSME3_HUMANBioGRID27215384 details
SKP1_HUMANFGF11_HUMANBioGRID28027390 details
SKP1_HUMANZNRF3_HUMANBioGRID29497989 details
SKP1_HUMANNMNA2_HUMANBioGRID29997255 details
SKP1_HUMANFXL16_HUMANBioGRID29499133 32345600 details
SKP1_HUMANCRBN_HUMANBioGRID29370161 details
SKP1_HUMANKCMA1_HUMANBioGRID29370161 details
SKP1_HUMANKLH12_HUMANBioGRID30190310 details
SKP1_HUMANFBX15_HUMANBioGRID, HPRD10531037 30596474 31130363 details
SKP1_HUMANFBX16_HUMANBioGRID, HPRD10531037 30596474 30714168 details
SKP1_HUMAN1433S_HUMANBioGRID30728155 details
SKP1_HUMANBACH1_HUMANBioGRID31257023 details
SKP1_HUMANDLG5_HUMANBioGRID31787846 details
SKP1_HUMANCF410_HUMANBioGRID32891887 details
SKP1_HUMANTR10B_HUMANBioGRID32313199 details
SKP1_HUMANMBD3_HUMANBioGRID33016927 details