Entity Details

Primary name AKA12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02952
EntryNameAKA12_HUMAN
FullNameA-kinase anchor protein 12
TaxID9606
Evidenceevidence at protein level
Length1782
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesAKAP12

GO terms

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GOName
GO:0005516 calmodulin binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0008179 adenylate cyclase binding
GO:0010738 regulation of protein kinase A signaling
GO:0010739 positive regulation of protein kinase A signaling
GO:0032496 response to lipopolysaccharide
GO:0032760 positive regulation of tumor necrosis factor production
GO:0035733 hepatic stellate cell activation
GO:0043025 neuronal cell body
GO:0043116 negative regulation of vascular permeability
GO:0050804 modulation of chemical synaptic transmission
GO:0051018 protein kinase A binding
GO:0051602 response to electrical stimulus
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0061870 positive regulation of hepatic stellate cell migration
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0090036 regulation of protein kinase C signaling
GO:0098685 Schaffer collateral - CA1 synapse
GO:1900143 positive regulation of oligodendrocyte apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR001573 A kinase-anchoring protein AKAP5 and AKAP12, calmodulin (CaM)-binding motifDomainDomain
IPR018459 RII binding domainDomainDomain
IPR028540 A-kinase anchor protein 12FamilyFamily

Diseases

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