Entity Details

Primary name MCL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07820
EntryNameMCL1_HUMAN
FullNameInduced myeloid leukemia cell differentiation protein Mcl-1
TaxID9606
Evidenceevidence at protein level
Length350
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesMCL1

GO terms

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GOName
GO:0001709 cell fate determination
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0007275 multicellular organism development
GO:0008320 protein transmembrane transporter activity
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010507 negative regulation of autophagy
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019725 cellular homeostasis
GO:0034097 response to cytokine
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0046982 protein heterodimerization activity
GO:0051434 BH3 domain binding
GO:0097136 Bcl-2 family protein complex
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:2000811 negative regulation of anoikis
GO:2001020 regulation of response to DNA damage stimulus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR013281 Apoptosis regulator, Mcl-1FamilyFamily
IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved siteSiteConserved site
IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved siteSiteConserved site
IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved siteSiteConserved site
IPR026298 Bcl-2 familyFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09401 IsosorbideDrugbanksmall molecule

Interactions

66 interactions

InteractorPartnerSourcesPublicationsLink
MCL1_HUMANHUWE1_HUMANBioGRID, DIP, HPRD, MINT, Molecular Connections15989957 16213503 19148187 20007713 20023629 21298030 21507240 21613222 21730980 21907705 22552282 25147182 27517746 28193319 29799788 32378766 details
MCL1_HUMANB2L11_HUMANBioGRID, HPRD, I2D, IntAct, MINT, Molecular Connections10837489 15694340 15721256 15989957 16213503 16697956 17097560 17525735 19148187 19150432 19483105 19622586 20074640 20085765 20159608 20836993 21132008 21199865 21507240 21613222 22516262 23245996 26045051 26186194 26859456 27013495 28514442 9731710 details
MCL1_HUMANBAK_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT, Molecular Connections10579309 10837489 15077116 15637055 15901672 17097560 18040043 19148187 19483105 19968986 20023629 20836993 21132008 21613222 22516262 23680104 26004684 26045051 26186194 27818144 28514442 32296183 details
MCL1_HUMANAPR_HUMANBioGRID, HPRD, I2D, IntAct, MINT15694340 15721256 15901672 16697956 19148187 20085765 21132008 21139584 21454712 21613222 22219388 22361683 23341456 26045051 27517746 29799788 32094511 32913203 details
MCL1_HUMANBID_HUMANBioGRID, DIP, HPRD, IntAct15637055 15694340 16697956 19074266 21613222 details
MCL1_HUMANBIK_HUMANBioGRID, HPRD, IntAct15694340 16697956 21613222 details
MCL1_HUMANBBC3_HUMANBioGRID, HPRD, IntAct15694340 15721256 16007132 16697956 21613222 21730980 22516262 26186194 26431330 28202514 28514442 details
MCL1_HUMANBAX_HUMANBioGRID, DIP, HPRD, IntAct, MINT10837489 15077116 17525735 18981409 19148187 19968986 21199865 21458670 21566062 26186194 28514442 details
MCL1_HUMANIEX1_HUMANIntAct15451437 details
MCL1_HUMANMCL1_HUMANBioGRID, HPRD, MINT10837489 19683529 details
MCL1_HUMANTNKS2_HUMANIntAct22153077 details
MCL1_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
MCL1_HUMANHRK_HUMANBioGRID, UniProt15031724 15694340 details
MCL1_HUMANSTX8_HUMANBioGRID, IntAct32296183 details
MCL1_HUMANKCNF1_HUMANBioGRID, IntAct32296183 details
MCL1_HUMANBMF_HUMANBioGRID, HPRD, IntAct11546872 15694340 15721256 16697956 32296183 details
MCL1_HUMANTRI11_HUMANBioGRID, IntAct26186194 28514442 32504673 details
MCL1_HUMANUSP9X_HUMANBioGRID, DIP20023629 21566062 21907705 23097624 23171055 details
MCL1_HUMANBBC3B_HUMANBioGRID, HPRD, IntAct15694340 15721256 16007132 16697956 21613222 21730980 26186194 26431330 28202514 28514442 details
MCL1_HUMANACM4_HUMANBioGRID, MINT28298427 details
MCL1_HUMANPCNA_HUMANBioGRID, HPRD, UniProt10978339 26030842 details
MCL1_HUMANBAD_HUMANBioGRID, HPRD10579309 10837489 11483855 15694340 details
MCL1_HUMANBOK_HUMANBioGRID, HPRD10579309 9356461 details
MCL1_HUMANCASP3_HUMANBioGRID, HPRD15637055 details
MCL1_HUMANVDAC1_HUMANBioGRID, HPRD15637055 details
MCL1_HUMANTNKS1_HUMANBioGRID, HPRD12475993 details
MCL1_HUMANDAD1_HUMANBioGRID, HPRD10965038 details
MCL1_HUMANMK10_HUMANBioGRID17670986 details
MCL1_HUMANPIN1_HUMANBioGRID17670986 details
MCL1_HUMANFBW1A_HUMANBioGRID17387146 19150432 details
MCL1_HUMANP53_HUMANBioGRID24491548 27818144 details
MCL1_HUMANTCTP_HUMANBioGRID, HPRD11598139 12149273 15870695 details
MCL1_HUMANTRAF6_HUMANBioGRID25340740 details
MCL1_HUMANFBXW7_HUMANBioGRID22608923 28202514 28522751 28619760 32081857 32276600 32352219 details
MCL1_HUMANUBXN6_HUMANBioGRID27913212 details
MCL1_HUMANGSK3B_HUMANBioGRID, HPRD16543145 17387146 details
MCL1_HUMANGSK3A_HUMANBioGRID, HPRD16543145 17387146 details
MCL1_HUMANMK01_HUMANBioGRID, HPRD15241487 17387146 details
MCL1_HUMANFBW1B_HUMANBioGRID17387146 details
MCL1_HUMANUBP13_HUMANBioGRID29335437 details
MCL1_HUMANEP300_HUMANBioGRID20829524 details
MCL1_HUMANHIF1A_HUMANBioGRID20829524 details
MCL1_HUMANAPEX1_HUMANBioGRID20829524 details
MCL1_HUMANCOX41_HUMANMINT19683529 details
MCL1_HUMANACTB_HUMANMINT19683529 details
MCL1_HUMANG3P_HUMANMINT19683529 details
MCL1_HUMANBECN1_HUMANBioGRID, MINT21139567 22219388 details
MCL1_HUMANCAV1_HUMANBioGRID, IntAct22277751 details
MCL1_HUMANBOP_HUMANIntAct23055042 details
MCL1_HUMANB2CL1_HUMANBioGRID, HPRD10837489 15077116 details
MCL1_HUMANHSP74_HUMANBioGRID19148187 21298030 details
MCL1_HUMANHSP7C_HUMANBioGRID19148187 details
MCL1_HUMANATG12_HUMANBioGRID22152474 details
MCL1_HUMANBAG3_HUMANBioGRID23341456 details
MCL1_HUMANHS71A_HUMANBioGRID23341456 details
MCL1_HUMANHS71B_HUMANBioGRID23341456 details
MCL1_HUMANBAG4_HUMANBioGRID23341456 details
MCL1_HUMANPRKN_HUMANBioGRID24999239 details
MCL1_HUMANPINK1_HUMANBioGRID24999239 details
MCL1_HUMANCUL1_HUMANBioGRID28522751 28776569 details
MCL1_HUMANSKP1_HUMANBioGRID28522751 28776569 details
MCL1_HUMANFBX4_HUMANBioGRID28776569 details
MCL1_HUMANERBB2_HUMANBioGRID26921175 details
MCL1_HUMANU17L2_HUMANBioGRID30718431 details
MCL1_HUMANOTUD1_HUMANBioGRID31467488 details
MCL1_HUMANSQSTM_HUMANBioGRID32585451 details