Entity Details

Primary name ACK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07912
EntryNameACK1_HUMAN
FullNameActivated CDC42 kinase 1
TaxID9606
Evidenceevidence at protein level
Length1038
SequenceStatuscomplete
DateCreated2003-10-24
DateModified2021-06-02

Ontological Relatives

GenesTNK2

GO terms

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GOName
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005095 GTPase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005154 epidermal growth factor receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0005912 adherens junction
GO:0006897 endocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0016020 membrane
GO:0016310 phosphorylation
GO:0030136 clathrin-coated vesicle
GO:0030154 cell differentiation
GO:0030659 cytoplasmic vesicle membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0045087 innate immune response
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050699 WW domain binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0070436 Grb2-EGFR complex
GO:0097268 cytoophidium
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000369 regulation of clathrin-dependent endocytosis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Cytoplasmic vesicle membrane
Endosome
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015116 Cdc42 binding domain-likeDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR021619 Mig-6 domainDomainDomain
IPR030220 Activated CDC42 kinase 1FamilyFamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR037085 Cdc42 binding domain-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB04367 DebromohymenialdisineDrugbanksmall molecule
DB11986 EntrectinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

95 interactions

InteractorPartnerSourcesPublicationsLink
ACK1_HUMANCDC42_HUMANBioGRID, HPRD, IntAct, mbinfo10360579 10684602 10802735 11157984 11394904 15123659 16052498 20086093 20936779 21311754 24413169 28539360 details
ACK1_HUMANSNX9_HUMANBioGRID, HPRD, MINT11799118 16137687 16316319 details
ACK1_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT11394904 14506255 16137687 20086093 20936779 21309750 22553920 28514442 28739485 8647288 details
ACK1_HUMANNCK1_HUMANBioGRID, HPRD, IntAct, MINT11278436 16137687 21309750 26496610 details
ACK1_HUMANCLH1_HUMANBioGRID, HPRD, IntAct, MINT11278436 16137687 19798056 26496610 28739485 details
ACK1_HUMANARSL_HUMANHPRD, IntAct16169070 details
ACK1_HUMANITFG2_HUMANHPRD, IntAct16169070 details
ACK1_HUMANRGF1C_HUMANHPRD, IntAct16169070 details
ACK1_HUMANRL18A_HUMANHPRD, IntAct16169070 details
ACK1_HUMANSEZ6_HUMANHPRD, IntAct16169070 details
ACK1_HUMANSRSF5_HUMANHPRD, IntAct16169070 details
ACK1_HUMANVTI1B_HUMANHPRD, IntAct16169070 details
ACK1_HUMANPTPRC_HUMANIntAct19167335 details
ACK1_HUMANPTPRJ_HUMANIntAct19167335 details
ACK1_HUMANPTN12_HUMANIntAct19167335 details
ACK1_HUMANACK1_HUMANBioGRID, IntAct, MINT14506255 16472662 20979614 25416956 31980649 details
ACK1_HUMANPAK2_HUMANMINT20696164 details
ACK1_HUMANSIAH1_HUMANBioGRID, IntAct21988832 23208506 details
ACK1_HUMANSOCS4_HUMANBioGRID, IntAct25814554 details
ACK1_HUMANHSH2D_HUMANBioGRID, HPRD, IntAct11700021 25814554 details
ACK1_HUMANSH21A_HUMANBioGRID, IntAct25416956 25910212 details
ACK1_HUMANGALT_HUMANBioGRID, IntAct25416956 25910212 details
ACK1_HUMANAQP1_HUMANBioGRID, IntAct25416956 details
ACK1_HUMANNT2NA_HUMANBioGRID, IntAct25416956 details
ACK1_HUMANNEK6_HUMANBioGRID, IntAct25416956 details
ACK1_HUMANBAG3_HUMANBioGRID, IntAct19144635 26496610 details
ACK1_HUMANDPH2_HUMANBioGRID, IntAct32296183 details
ACK1_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
ACK1_HUMANSH21B_HUMANBioGRID, IntAct32296183 details
ACK1_HUMANP55G_HUMANBioGRID, IntAct32296183 details
ACK1_HUMANANDR_HUMANBioGRID, DIP17494760 31819114 details
ACK1_HUMANATL4_HUMANIntAct31515488 details
ACK1_HUMANFYN_HUMANBioGRID, HPRD11087735 14506255 details
ACK1_HUMANNEDD4_HUMANBioGRID20086093 23686771 details
ACK1_HUMANNED4L_HUMANBioGRID19144635 23686771 details
ACK1_HUMANSMUF1_HUMANBioGRID19144635 details
ACK1_HUMANWWP2_HUMANBioGRID19144635 details
ACK1_HUMANHECW1_HUMANBioGRID19144635 details
ACK1_HUMANMAGI3_HUMANBioGRID19144635 details
ACK1_HUMANWWOX_HUMANBioGRID, HPRD16288044 19144635 details
ACK1_HUMANSRC_HUMANBioGRID14506255 17038317 19144635 21309750 details
ACK1_HUMANPGFRB_HUMANBioGRID19815557 25257795 details
ACK1_HUMANNPHP1_HUMANBioGRID18477472 21309750 details
ACK1_HUMANWASP_HUMANBioGRID16257963 details
ACK1_HUMANYES_HUMANBioGRID21309750 details
ACK1_HUMANHCK_HUMANBioGRID14506255 21309750 details
ACK1_HUMANLYN_HUMANBioGRID21309750 details
ACK1_HUMANSRC8_HUMANBioGRID22952966 details
ACK1_HUMANKCNA5_HUMANBioGRID14506255 details
ACK1_HUMANKR103_HUMANBioGRID25416956 details
ACK1_HUMANNT2NC_HUMANBioGRID25416956 details
ACK1_HUMANAKT1_HUMANBioGRID25257795 25945695 details
ACK1_HUMANFGFR1_HUMANBioGRID25945695 details
ACK1_HUMANSYNJ1_HUMANMINT16137687 details
ACK1_HUMANEGFR_HUMANBioGRID, HPRD, IntAct15657067 17182860 18271526 18435854 19815557 20086093 20359967 24413169 8497321 8647288 details
ACK1_HUMANBCAR1_HUMANBioGRID, MINT17038317 details
ACK1_HUMANCRK_HUMANMINT17038317 details
ACK1_HUMANHS90B_HUMANBioGRID, IntAct22939624 28739485 31980649 details
ACK1_HUMANCDC37_HUMANBioGRID, IntAct28514442 28739485 31980649 details
ACK1_HUMANHS90A_HUMANBioGRID, IntAct16288044 22939624 23729439 28739485 31980649 details
ACK1_HUMANADT2_HUMANBioGRID, IntAct28739485 31980649 details
ACK1_HUMANMCF2_HUMANBioGRID, HPRD10652228 details
ACK1_HUMANCLCA_HUMANBioGRID19144635 details
ACK1_HUMANAMPH_HUMANBioGRID19144635 details
ACK1_HUMANBIN1_HUMANBioGRID19144635 details
ACK1_HUMANFABP4_HUMANBioGRID19144635 details
ACK1_HUMANKAT8_HUMANBioGRID22586264 details
ACK1_HUMANKAT5_HUMANBioGRID22586264 details
ACK1_HUMANUFO_HUMANBioGRID19815557 details
ACK1_HUMANLTK_HUMANBioGRID19815557 details
ACK1_HUMANALK_HUMANBioGRID19815557 details
ACK1_HUMANEEA1_HUMANBioGRID18262180 details
ACK1_HUMANMERTK_HUMANBioGRID, HPRD16288044 details
ACK1_HUMANZBT16_HUMANBioGRID15964811 details
ACK1_HUMANEP300_HUMANBioGRID15964811 details
ACK1_HUMANP73_HUMANBioGRID15175157 details
ACK1_HUMANSIAH2_HUMANBioGRID23208506 details
ACK1_HUMANA16L1_HUMANBioGRID24413169 details
ACK1_HUMANSQSTM_HUMANBioGRID24413169 details
ACK1_HUMANNBR1_HUMANBioGRID24413169 details
ACK1_HUMANP53_HUMANBioGRID23402884 details
ACK1_HUMANNTRK1_HUMANBioGRID23598414 details
ACK1_HUMANNTRK2_HUMANBioGRID23598414 details
ACK1_HUMANNTRK3_HUMANBioGRID23598414 details
ACK1_HUMANTRI50_HUMANBioGRID24308962 details
ACK1_HUMANKDM3A_HUMANBioGRID25148682 details
ACK1_HUMANPDK1_HUMANBioGRID25257795 details
ACK1_HUMANLCP2_HUMANBioGRID28188290 details
ACK1_HUMANSTAT1_HUMANBioGRID28739485 details
ACK1_HUMANGRP75_HUMANBioGRID28739485 details
ACK1_HUMANCSK_HUMANBioGRID28739485 details
ACK1_HUMANHAX1_HUMANBioGRID28739485 details
ACK1_HUMANCRKL_HUMANBioGRID28739485 details
ACK1_HUMANCSPG4_HUMANHPRD10587647 details
ACK1_HUMANRGRF1_HUMANHPRD10882715 details