Entity Details

Primary name ACTN3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08043
EntryNameACTN3_HUMAN
FullNameAlpha-actinin-3
TaxID9606
Evidenceevidence at protein level
Length901
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesACTN3

GO terms

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GOName
GO:0003779 actin binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005925 focal adhesion
GO:0008307 structural constituent of muscle
GO:0014728 regulation of the force of skeletal muscle contraction
GO:0014732 skeletal muscle atrophy
GO:0014883 transition between fast and slow fiber
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0030049 muscle filament sliding
GO:0031143 pseudopodium
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0044325 transmembrane transporter binding
GO:0045820 negative regulation of glycolytic process
GO:0048041 focal adhesion assembly
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0070062 extracellular exosome
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0090324 negative regulation of oxidative phosphorylation
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1903715 regulation of aerobic respiration
GO:1904025 positive regulation of glucose catabolic process to lactate via pyruvate

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014837 EF-hand, Ca insensitiveDomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
ACTN3_HUMANTITIN_HUMANBioGRID, IntAct23414517 details
ACTN3_HUMANDUX1_HUMANBioGRID, IntAct26816005 details
ACTN3_HUMANDUX4C_HUMANIntAct26816005 details
ACTN3_HUMANSCRIB_HUMANMINT24550280 details
ACTN3_HUMANRTP5_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANHGS_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANODF3B_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANMYOZ1_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANMYOTI_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANC2CD6_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANSYP2L_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANMILK2_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANCTG1B_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANNKAP1_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANUBP2_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANF90A1_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANMAGA6_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANPKP2_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANTRI29_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANPO6F2_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANACTN4_HUMANBioGRID, HPRD, IntAct10656685 25416956 32296183 details
ACTN3_HUMANCTDS1_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANACPM_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANDDAH2_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANATP23_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANK2C6C_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANZN426_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANZN343_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANCT085_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANLHX3_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANACTN3_HUMANBioGRID, HPRD, IntAct25416956 32296183 9675099 details
ACTN3_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANTRAF1_HUMANBioGRID, IntAct25416956 32296183 details
ACTN3_HUMANSNAI1_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANACTN1_HUMANBioGRID, IntAct25416956 32296183 details
ACTN3_HUMANPCCB_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANGLIS2_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANPPR18_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANPTK6_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANCXCL5_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANIVD_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANSOLH1_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANASB9_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANHXD12_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANECM1_HUMANBioGRID, IntAct32296183 details
ACTN3_HUMANPCNA_HUMANUniProt26030842 details
ACTN3_HUMANPKHG2_HUMANBioGRID, IntAct25416956 29892012 details
ACTN3_HUMANMYPN_HUMANBioGRID, HPRD11309420 details
ACTN3_HUMANACTN2_HUMANBioGRID, HPRD10656685 9675099 details
ACTN3_HUMANREL_HUMANBioGRID25416956 details
ACTN3_HUMANTRAF2_HUMANBioGRID25416956 details
ACTN3_HUMANNEBL_HUMANBioGRID25416956 details
ACTN3_HUMANABI3_HUMANBioGRID25416956 details
ACTN3_HUMANRN111_HUMANBioGRID25416956 details
ACTN3_HUMANCA094_HUMANBioGRID25416956 details
ACTN3_HUMANKCTD6_HUMANBioGRID25416956 details
ACTN3_HUMANBRCA1_HUMANBioGRID25184681 details
ACTN3_HUMANCAPS1_HUMANBioGRID32296183 details
ACTN3_HUMANDUX5_HUMANBioGRID26816005 details
ACTN3_HUMANNRAP_HUMANHPRD12692149 details
ACTN3_HUMANAA2AR_HUMANHPRD12837758 details
ACTN3_HUMANF16P1_HUMANMINT12507293 details