Entity Details

Primary name MD2L1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13257
EntryNameMD2L1_HUMAN
FullNameMitotic spindle assembly checkpoint protein MAD2A
TaxID9606
Evidenceevidence at protein level
Length205
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesMAD2L1

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0000776 kinetochore
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007052 mitotic spindle organization
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007096 regulation of exit from mitosis
GO:0008022 protein C-terminus binding
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0042177 negative regulation of protein catabolic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0044615 nuclear pore nuclear basket
GO:0045930 negative regulation of mitotic cell cycle
GO:0048471 perinuclear region of cytoplasm
GO:0051301 cell division
GO:0051660 establishment of centrosome localization
GO:0072686 mitotic spindle
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1904667 negative regulation of ubiquitin protein ligase activity

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003511 HORMA domainDomainDomain
IPR036570 HORMA domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
MD2L1_HUMANINSR_HUMANBioGRID, HPRD, IntAct, MINT32296183 9092546 details
MD2L1_HUMANADA17_HUMANBioGRID, HPRD, UniProt10527948 11741929 details
MD2L1_HUMANT22D4_HUMANBioGRID, HPRD, IntAct16189514 25416956 26186194 28514442 details
MD2L1_HUMANMD1L1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10660610 11459826 11707408 15694304 16189514 18318601 18692475 21041666 21525009 21772247 21988832 22493223 24581499 25012665 25422469 26258632 26264872 26496610 26986935 29997244 31467278 31515488 31588029 32296183 32814053 details
MD2L1_HUMANCDC20_HUMANBioGRID, DIP, HPRD, IntAct, MINT10700282 11274370 11438673 11702782 11707408 11804586 12196507 14561775 14607335 15182668 15694304 16497171 16525508 17360335 17443180 17443186 18022367 18318601 18592005 18794143 18997788 19098431 19143472 19826003 20054826 20081372 20212161 20360068 20512932 21041666 21300909 21335556 21407176 21525009 21743465 21772247 21926987 22100920 22340593 23007648 23239745 23443559 23643811 23754430 23791783 24151075 24464857 24581499 25012665 25092294 25306918 25383541 25482201 25669885 25673878 25750436 26496610 26811472 26912231 26986935 27939943 28096334 28410192 29973720 31118282 31588029 9628895 9637688 9736712 details
MD2L1_HUMANMD2L1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11551900 15694304 16525508 18022367 18318601 21041666 21772247 details
MD2L1_HUMANMD2BP_HUMANBioGRID, DIP, HPRD, IntAct, MINT12456649 16525508 18022368 21666598 21772247 22100920 25416956 25502805 26496610 29973720 31118282 31515488 32296183 details
MD2L1_HUMANKEAP1_HUMANBioGRID, IntAct19615732 23382044 25416956 31515488 32296183 details
MD2L1_HUMANCDC27_HUMANBioGRID, DIP, HPRD, IntAct, MINT11707408 17443180 17443186 20054826 20081372 20212161 20951947 21335556 21525009 21772247 21926987 22100920 22193957 23754430 26496610 26811472 26986935 29432156 30341343 32076268 32152539 9356466 9628895 9736712 details
MD2L1_HUMANPRAF1_HUMANBioGRID, IntAct21988832 details
MD2L1_HUMANSGO2_HUMANMINT21666598 details
MD2L1_HUMANBUB1B_HUMANBioGRID, DIP, IntAct, MINT11535616 20212161 20512932 21300909 21525009 21772247 22000412 22100920 23754430 23791783 24151075 25012665 25383541 25482201 25669885 25673878 25852190 26986935 27939943 30341343 32152539 details
MD2L1_HUMANAPC4_HUMANBioGRID, DIP, MINT21335556 21926987 23007648 23160376 23288039 24151075 25383541 25673878 25750436 26986935 27097363 27939943 32152539 details
MD2L1_HUMANSDCB1_HUMANBioGRID, IntAct25416956 details
MD2L1_HUMANDEPD5_HUMANBioGRID, IntAct32296183 details
MD2L1_HUMANEPMIP_HUMANBioGRID, IntAct32296183 details
MD2L1_HUMANMD2L2_HUMANBioGRID, HPRD, UniProt10660610 29656893 30111544 details
MD2L1_HUMANPCH2_HUMANBioGRID, DIP25012665 26324890 26986935 29973720 details
MD2L1_HUMANESR2_HUMANBioGRID, HPRD10706629 details
MD2L1_HUMANREV3L_HUMANBioGRID10660610 details
MD2L1_HUMANUBD_HUMANBioGRID, HPRD10200259 16495226 25422469 details
MD2L1_HUMANIL3RB_HUMANBioGRID, HPRD11551900 details
MD2L1_HUMANA4_HUMANBioGRID21832049 details
MD2L1_HUMANCCNA2_HUMANBioGRID25669885 details
MD2L1_HUMANBUB1_HUMANBioGRID25422469 25669885 details
MD2L1_HUMANH31_HUMANBioGRID27198228 details
MD2L1_HUMANTNR1B_HUMANIntAct14743216 details
MD2L1_HUMANZWINT_HUMANUniProt16732327 details
MD2L1_HUMANTP4A3_HUMANIntAct17353931 details
MD2L1_HUMANMAGB2_HUMANIntAct17353931 details
MD2L1_HUMANIF6_HUMANIntAct17353931 details
MD2L1_HUMANIKKE_HUMANIntAct17353931 details
MD2L1_HUMANDC1L1_HUMANMINT19229290 details
MD2L1_HUMANCDC16_HUMANBioGRID, HPRD, IntAct20360068 9356466 9628895 details
MD2L1_HUMANP73_HUMANBioGRID, IntAct22340593 details
MD2L1_HUMANKI20A_HUMANBioGRID, IntAct26496610 26986935 details
MD2L1_HUMANAPC1_HUMANBioGRID, IntAct26496610 26986935 details
MD2L1_HUMANADA15_HUMANBioGRID11741929 details
MD2L1_HUMANADA10_HUMANBioGRID11741929 details
MD2L1_HUMANAPC_HUMANBioGRID9637688 details
MD2L1_HUMANCHFR_HUMANBioGRID18592005 details
MD2L1_HUMANUBE2C_HUMANBioGRID17443186 details
MD2L1_HUMANNSL1_HUMANBioGRID20231385 details
MD2L1_HUMANCUED2_HUMANBioGRID21743465 details
MD2L1_HUMANHSF1_HUMANBioGRID18794143 details
MD2L1_HUMANANC2_HUMANBioGRID, HPRD11438673 9637688 details
MD2L1_HUMANBUB3_HUMANBioGRID21525009 24151075 26986935 details
MD2L1_HUMANDAXX_HUMANBioGRID23239745 details
MD2L1_HUMANZW10_HUMANBioGRID15824131 details
MD2L1_HUMANCDC26_HUMANBioGRID25723520 details
MD2L1_HUMANNEK2_HUMANBioGRID25673878 details
MD2L1_HUMANAPC7_HUMANBioGRID26986935 details
MD2L1_HUMANPSMD8_HUMANBioGRID26986935 details
MD2L1_HUMANNUP98_HUMANBioGRID27097363 details
MD2L1_HUMANTRAP1_HUMANBioGRID28678347 details
MD2L1_HUMANFAT1_HUMANBioGRID25422469 details
MD2L1_HUMANFBX6_HUMANBioGRID30526252 details
MD2L1_HUMANERCC2_HUMANBioGRID18597777 details
MD2L1_HUMANERCC1_HUMANBioGRID18597777 details
MD2L1_HUMANNDC80_HUMANHPRD12351790 details
MD2L1_HUMANMBL2_HUMANHPRD11804586 details