Entity Details

Primary name ADAM9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13443
EntryNameADAM9_HUMAN
FullNameDisintegrin and metalloproteinase domain-containing protein 9
TaxID9606
Evidenceevidence at protein level
Length819
SequenceStatuscomplete
DateCreated2002-10-19
DateModified2021-06-02

Ontological Relatives

GenesADAM9

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0004222 metalloendopeptidase activity
GO:0005080 protein kinase C binding
GO:0005178 integrin binding
GO:0005518 collagen binding
GO:0005615 extracellular space
GO:0005925 focal adhesion
GO:0006509 membrane protein ectodomain proteolysis
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0008237 metallopeptidase activity
GO:0009986 cell surface
GO:0010042 response to manganese ion
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0016485 protein processing
GO:0017124 SH3 domain binding
GO:0030216 keratinocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0031233 intrinsic component of external side of plasma membrane
GO:0031293 membrane protein intracellular domain proteolysis
GO:0033627 cell adhesion mediated by integrin
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034241 positive regulation of macrophage fusion
GO:0034612 response to tumor necrosis factor
GO:0042117 monocyte activation
GO:0042542 response to hydrogen peroxide
GO:0042987 amyloid precursor protein catabolic process
GO:0043236 laminin binding
GO:0046872 metal ion binding
GO:0050714 positive regulation of protein secretion
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051384 response to glucocorticoid
GO:0051549 positive regulation of keratinocyte migration
GO:0051592 response to calcium ion
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR001762 Disintegrin domainDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR006586 ADAM, cysteine-rich domainDomainDomain
IPR018358 Disintegrin, conserved siteSiteConserved site
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR034027 Reprolysin domain, adamalysin-typeDomainDomain
IPR036436 Disintegrin domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05033 INCB7839Drugbanksmall molecule