Entity Details

Primary name NDF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13562
EntryNameNDF1_HUMAN
FullNameNeurogenic differentiation factor 1
TaxID9606
Evidenceevidence at protein level
Length356
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesNEUROD1

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003326 pancreatic A cell fate commitment
GO:0003329 pancreatic PP cell fate commitment
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006913 nucleocytoplasmic transport
GO:0007263 nitric oxide mediated signal transduction
GO:0008134 transcription factor binding
GO:0009749 response to glucose
GO:0009952 anterior/posterior pattern specification
GO:0021542 dentate gyrus development
GO:0021549 cerebellum development
GO:0022008 neurogenesis
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030073 insulin secretion
GO:0030182 neuron differentiation
GO:0031018 endocrine pancreas development
GO:0035881 amacrine cell differentiation
GO:0035883 enteroendocrine cell differentiation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0045597 positive regulation of cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0046982 protein heterodimerization activity
GO:0048562 embryonic organ morphogenesis
GO:0048666 neuron development
GO:0048839 inner ear development
GO:0050796 regulation of insulin secretion
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060730 regulation of intestinal epithelial structure maintenance
GO:0070888 E-box binding
GO:0071333 cellular response to glucose stimulus
GO:0090575 RNA polymerase II transcription regulator complex
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
GO:2000679 positive regulation of transcription regulatory region DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR016637 Neurogenic differentiation factor NeuroDFamilyFamily
IPR022575 Neurogenic differentiation factor, domain of unknown functionDomainDomain
IPR032652 Neurogenic differentiation factor 1FamilyFamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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