Entity Details

Primary name TDG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13569
EntryNameTDG_HUMAN
FullNameG/T mismatch-specific thymine DNA glycosylase
TaxID9606
Evidenceevidence at protein level
Length410
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesTDG

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0004844 uracil DNA N-glycosylase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0006284 base-excision repair
GO:0006285 base-excision repair, AP site formation
GO:0006287 base-excision repair, gap-filling
GO:0006298 mismatch repair
GO:0006325 chromatin organization
GO:0008134 transcription factor binding
GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0019104 DNA N-glycosylase activity
GO:0019904 protein domain specific binding
GO:0030983 mismatched DNA binding
GO:0031402 sodium ion binding
GO:0031404 chloride ion binding
GO:0032183 SUMO binding
GO:0035511 oxidative DNA demethylation
GO:0040029 regulation of gene expression, epigenetic
GO:0042803 protein homodimerization activity
GO:0043621 protein self-association
GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity
GO:0045008 depyrimidination
GO:0045995 regulation of embryonic development
GO:0080111 DNA demethylation
GO:1902544 regulation of DNA N-glycosylase activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003310 G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotesFamilyFamily
IPR005122 Uracil-DNA glycosylase-likeDomainDomain
IPR015637 Uracil DNA glycosylase family 2FamilyFamily
IPR036895 Uracil-DNA glycosylase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

58 interactions

InteractorPartnerSourcesPublicationsLink
TDG_HUMANSYUA_HUMANIntAct32814053 details
TDG_HUMANSUMO1_HUMANBioGRID, DIP, HPRD, MINT10961991 11889051 15959518 16524884 16763556 17060459 21284855 details
TDG_HUMANAPBB2_HUMANIntAct32814053 details
TDG_HUMANNFL_HUMANIntAct32814053 details
TDG_HUMANGCR_HUMANBioGRID12874288 details
TDG_HUMANRARA_HUMANBioGRID12874288 24394593 details
TDG_HUMANP73_HUMANBioGRID10961991 18951877 details
TDG_HUMANDNM3B_HUMANBioGRID18452947 details
TDG_HUMANRAD9A_HUMANBioGRID17855402 details
TDG_HUMANSKIL_HUMANBioGRID, HPRD, MINT15231748 details
TDG_HUMANCRK_HUMANBioGRID, IntAct25814554 details
TDG_HUMANPML_HUMANBioGRID, HPRD15569683 17060459 details
TDG_HUMANDX39B_HUMANHPRD, IntAct14667819 details
TDG_HUMANCBP_HUMANBioGRID, HPRD11864601 17060459 24394593 24532795 24748645 28680062 details
TDG_HUMANSMAD4_HUMANBioGRID, HPRD, MINT15231748 details
TDG_HUMANPRGR_HUMANBioGRID, IntAct12874288 16282588 details
TDG_HUMANP53_HUMANBioGRID10961991 18951877 details
TDG_HUMANIKZF1_HUMANBioGRID, IntAct21988832 details
TDG_HUMANSTAT3_HUMANBioGRID, IntAct25814554 details
TDG_HUMANSUMO2_HUMANBioGRID, DIP, HPRD11889051 16524884 16620772 16626738 19394292 details
TDG_HUMANSNIP1_HUMANHPRD, MINT15231748 details
TDG_HUMANKIF1B_HUMANIntAct32814053 details
TDG_HUMANUBC9_HUMANBioGRID17060459 18691969 24753249 details
TDG_HUMANPAIRB_HUMANBioGRID, HPRD16679534 details
TDG_HUMANXPC_HUMANBioGRID, HPRD12505994 details
TDG_HUMANRAD1_HUMANBioGRID17855402 details
TDG_HUMANJUN_HUMANHPRD1631061 details
TDG_HUMANTDG_HUMANDIP, HPRD14667819 18587051 details
TDG_HUMANVDR_HUMANBioGRID, HPRD12874288 details
TDG_HUMANEPM2A_HUMANBioGRID26493215 details
TDG_HUMANSUMO3_HUMANBioGRID, HPRD11889051 16620772 details
TDG_HUMANESR1_HUMANBioGRID, HPRD, IntAct12874288 16282588 details
TDG_HUMANTHA_HUMANBioGRID, HPRD12874288 details
TDG_HUMANMX1_HUMANBioGRID25447205 details
TDG_HUMANHUS1_HUMANBioGRID17855402 details
TDG_HUMANJUNB_HUMANBioGRID, IntAct21988832 details
TDG_HUMANGRN_HUMANIntAct32814053 details
TDG_HUMANTTHY_HUMANIntAct32814053 details
TDG_HUMANRNF11_HUMANIntAct32814053 details
TDG_HUMANEP300_HUMANBioGRID, HPRD11864601 details
TDG_HUMANP63_HUMANBioGRID18951877 details
TDG_HUMANRXRA_HUMANBioGRID, HPRD12874288 details
TDG_HUMANPCNA_HUMANBioGRID24962565 details
TDG_HUMANSETX_HUMANUniProt24244371 details
TDG_HUMANANDR_HUMANBioGRID12874288 details
TDG_HUMANDTL_HUMANBioGRID24962565 details
TDG_HUMANWFS1_HUMANIntAct32814053 details
TDG_HUMANSIR6_HUMANBioGRID23240041 details
TDG_HUMANRD23B_HUMANHPRD12505994 details
TDG_HUMANHSPB1_HUMANIntAct32814053 details
TDG_HUMANNKX21_HUMANHPRD11438542 details
TDG_HUMANPRPS1_HUMANIntAct32814053 details
TDG_HUMANAICDA_HUMANIntAct21722948 details
TDG_HUMANNCOA1_HUMANIntAct16282588 details
TDG_HUMANGA45A_HUMANIntAct21722948 details
TDG_HUMANITF2_HUMANBioGRID24532795 details
TDG_HUMANRNF4_HUMANBioGRID20696907 details
TDG_HUMANKDM6B_HUMANBioGRID26544625 details