Entity Details

Primary name AVR2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13705
EntryNameAVR2B_HUMAN
FullNameActivin receptor type-2B
TaxID9606
Evidenceevidence at protein level
Length512
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesACVR2B

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009952 anterior/posterior pattern specification
GO:0017002 activin-activated receptor activity
GO:0019838 growth factor binding
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0043235 receptor complex
GO:0045669 positive regulation of osteoblast differentiation
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0060836 lymphatic endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0061298 retina vasculature development in camera-type eye
GO:0071363 cellular response to growth factor stimulus
GO:0120163 negative regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613751 OMIMHeterotaxy, visceral, 4, autosomal (HTX4)A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can be associated with a variety of congenital defects including cardiac malformations. HTX4 clinical features include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver. The disease is caused by variants affecting the gene represented in this entry.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
AVR2B_HUMANFSTL1_HUMANMINT20860622 details
AVR2B_HUMANGDF11_HUMANHPRD, MINT16845371 21054789 details
AVR2B_HUMANGDF8_HUMANBioGRID, HPRD, MINT11459935 23829672 details
AVR2B_HUMANSYJ2B_HUMANBioGRID, HPRD11882656 15451561 details
AVR2B_HUMANERBIN_HUMANBioGRID15123239 details
AVR2B_HUMANGDF2_HUMANBioGRID22718755 details
AVR2B_HUMANBMP10_HUMANBioGRID22718755 details
AVR2B_HUMANFBX7_HUMANBioGRID27503909 details
AVR2B_HUMANTDGF1_HUMANBioGRID28126904 details
AVR2B_HUMANNODAL_HUMANBioGRID28126904 details
AVR2B_HUMANHS90B_HUMANIntAct22939624 details
AVR2B_HUMANACV1B_HUMANBioGRID, HPRD8612709 8622651 details
AVR2B_HUMANGDF5_HUMANBioGRID, HPRD8702914 details
AVR2B_HUMANEGLN_HUMANBioGRID9872992 details
AVR2B_HUMANINHBB_HUMANBioGRID, HPRD9202237 details
AVR2B_HUMANINHBA_HUMANBioGRID, HPRD8242742 9202237 details
AVR2B_HUMANBMP6_HUMANBioGRID10504300 details
AVR2B_HUMANBMP7_HUMANBioGRID, HPRD9748228 details
AVR2B_HUMANSNX6_HUMANBioGRID, HPRD11279102 details
AVR2B_HUMANSNX2_HUMANBioGRID, HPRD11279102 details
AVR2B_HUMANSNX1_HUMANBioGRID, HPRD11279102 details
AVR2B_HUMANIGSF1_HUMANBioGRID, HPRD11266516 details
AVR2B_HUMANSMAD2_HUMANBioGRID11094085 details
AVR2B_HUMANSMAD7_HUMANBioGRID20663871 details
AVR2B_HUMANSMAD6_HUMANBioGRID20663871 details
AVR2B_HUMANHS90A_HUMANBioGRID22939624 details
AVR2B_HUMANPEG10_HUMANBioGRID15611116 details
AVR2B_HUMANRGMB_HUMANBioGRID15671031 details
AVR2B_HUMANPSDE_HUMANBioGRID31685442 details
AVR2B_HUMANINHBC_HUMANHPRD12651901 details
AVR2B_HUMANTGFA1_HUMANHPRD11278302 details
AVR2B_HUMANBMP2_HUMANHPRD15064755 details