Entity Details

Primary name DVL1
Entity type gene
Source Source Link

Details

PrimaryID1855
RefseqGeneNG_008048
SymbolDVL1
Namedishevelled segment polarity protein 1
Chromosome1
Location1p36.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1997-11-18
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsDVL1_HUMAN

GO terms

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GOName
GO:0001505 regulation of neurotransmitter levels
GO:0001934 positive regulation of protein phosphorylation
GO:0005109 frizzled binding
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006355 regulation of transcription, DNA-templated
GO:0006469 negative regulation of protein kinase activity
GO:0007269 neurotransmitter secretion
GO:0007411 axon guidance
GO:0007528 neuromuscular junction development
GO:0008013 beta-catenin binding
GO:0010976 positive regulation of neuron projection development
GO:0014069 postsynaptic density
GO:0016328 lateral plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0021915 neural tube development
GO:0022007 convergent extension involved in neural plate elongation
GO:0030136 clathrin-coated vesicle
GO:0030426 growth cone
GO:0031122 cytoplasmic microtubule organization
GO:0031267 small GTPase binding
GO:0031410 cytoplasmic vesicle
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 protein localization to nucleus
GO:0035176 social behavior
GO:0035372 protein localization to microtubule
GO:0035556 intracellular signal transduction
GO:0035567 non-canonical Wnt signaling pathway
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043113 receptor clustering
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048668 collateral sprouting
GO:0048675 axon extension
GO:0048813 dendrite morphogenesis
GO:0050808 synapse organization
GO:0050821 protein stabilization
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060134 prepulse inhibition
GO:0060997 dendritic spine morphogenesis
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0099054 presynapse assembly
GO:0150012 positive regulation of neuron projection arborization
GO:1903827 regulation of cellular protein localization
GO:1904886 beta-catenin destruction complex disassembly
GO:1905386 positive regulation of protein localization to presynapse
GO:1990909 Wnt signalosome
GO:2000300 regulation of synaptic vesicle exocytosis
GO:2000463 positive regulation of excitatory postsynaptic potential

Diseases

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Disease IDSourceNameDescription
616331 OMIMRobinow syndrome, autosomal dominant 2 (DRS2)A rare skeletal dysplasia syndrome characterized by dysmorphic features resembling a fetal face, mesomelic limb shortening, hypoplastic external genitalia in males, costovertebral segmentation defects, and renal anomalies. The disease is caused by variants affecting the gene represented in this entry.

Interactions

100 interactions

InteractorPartnerSourcesPublicationsLink
DVL1USP13BioGRID, HPRD, IntAct16169070 details
DVL1PSMA3BioGRID, IntAct21988832 details
DVL1SIPA1BioGRID, IntAct21988832 details
DVL1ANXA7BioGRID, MINT21900206 details
DVL1DAAM1HPRD, MINT11779461 22705156 details
DVL1LRRK2BioGRID, IntAct19625296 details
DVL1TPTEP2-CSNK1EIntAct11425858 details
DVL1CSNK1EBioGRID, HPRD, IntAct11425858 11487578 11818547 details
DVL1DVL3bhf-ucl, BioGRID, HPRD10330181 32296183 details
DVL1BUB1BioGRID, MINT24412244 details
DVL1FBXW7BioGRID, MINT24412244 details
DVL1MLH3BioGRID, MINT24412244 details
DVL1MSH2BioGRID, MINT24412244 details
DVL1RB1BioGRID, MINT24412244 details
DVL1SCYL2bhf-ucl19643732 details
DVL1EPS8BioGRID, HPRD10581192 details
DVL1HECW1BioGRID, HPRD14684739 details
DVL1DAB2BioGRID12805222 details
DVL1SMAD1BioGRID12650946 details
DVL1SMAD2BioGRID, HPRD12650946 details
DVL1SMAD3BioGRID, HPRD12650946 details
DVL1SMAD4BioGRID, HPRD12650946 details
DVL1SMAD7BioGRID, HPRD12650946 details
DVL1AXIN1BioGRID, HPRD10330403 10428961 12556519 18632848 9482734 details
DVL1ATN1BioGRID10332026 details
DVL1CSNK1DBioGRID, HPRD11818547 details
DVL1NEDD4BioGRID22467858 details
DVL1NCK2BioGRID25416956 details
DVL1TRIM69BioGRID25416956 details
DVL1SMYD1BioGRID32296183 details
DVL1KLHL12BioGRID32296183 32574548 details
DVL1BAG3BioGRID32296183 details
DVL1BRD7HPRD12941796 details
DVL1VANGL1HPRD15456783 details
DVL1PPM1AHPRD10644691 details
DVL1DYNLT1HPRD10644691 details
DVL1HDHD2HPRD16169070 details
DVL1CCDC88CHPRD14750955 details
DVL1ARHGEF19MINT18256687 details
DVL1APCIntAct, MINT11425858 20224554 details
DVL1DVL2BioGRID, MINT20224554 24643799 26186194 28514442 31340145 details
DVL1TFDP1MINT22773187 details
DVL1CTNNB1BioGRID, HPRD, IntAct10806215 25241761 details
DVL1CSNK2A1BioGRID, HPRD, IntAct10806215 25241761 details
DVL1DVL1bhf-ucl, BioGRID, HPRD10330181 details
DVL1WWTR1bhf-ucl, BioGRID20412773 details
DVL1NKD2bhf-ucl, BioGRID20177058 details
DVL1SIRT1BioGRID, DIP20439735 details
DVL1ARRB1BioGRID, HPRD11742073 details
DVL1FRAT1BioGRID, HPRD10428961 details
DVL1CYLDBioGRID20227366 details
DVL1SDC4BioGRID20639201 details
DVL1ITCHBioGRID22826439 details
DVL1HUWE1BioGRID24643799 details
DVL1NUMA1BioGRID24469800 details
DVL1STAU1BioGRID29395067 details
DVL1VANGL2HPRD12490194 details
DVL1RAC1HPRD12533515 details
DVL1PTK2MINT20224554 details
DVL1RASSF9BioGRID, IntAct24366813 details
DVL1RASSF10BioGRID, IntAct24366813 details
DVL1KIAA0753BioGRID, IntAct26638075 details
DVL1CEP128BioGRID, IntAct26638075 details
DVL1TMEM17BioGRID, IntAct26638075 details
DVL1AHI1BioGRID, IntAct26638075 details
DVL1CEP19BioGRID, IntAct26638075 details
DVL1SSX2IPBioGRID, IntAct26638075 details
DVL1CCP110BioGRID, IntAct26638075 details
DVL1CETN2BioGRID, IntAct26638075 details
DVL1DCTN1BioGRID, IntAct26638075 details
DVL1CEP135BioGRID, IntAct26638075 details
DVL1CEP44BioGRID, IntAct26638075 details
DVL1CEP83BioGRID, IntAct26638075 details
DVL1PLGRKTIntAct29568061 details
DVL1TOMM20BioGRID, IntAct29568061 details
DVL1WWOXBioGRID24550385 30619736 details
DVL1FLNCBioGRID26186194 details
DVL1BTRCBioGRID25900982 details
DVL1XPO1BioGRID26673895 details
DVL1WWP2BioGRID25071155 details
DVL1MAP2K3BioGRID27684187 details
DVL1ARHGEF2BioGRID29089450 details
DVL1PTRH2BioGRID29568061 details
DVL1LTN1BioGRID29540532 details
DVL1RPS6KA2BioGRID31678930 details
DVL1DCAF4BioGRID30945288 details
DVL1RMDN3BioGRID32877691 details
DVL1AGPSBioGRID34079125 details
DVL1ANKFY1BioGRID34079125 details
DVL1CTNNA1BioGRID34079125 details
DVL1EPB41L4ABioGRID34079125 details
DVL1GJA1BioGRID34079125 details
DVL1KRT8BioGRID34079125 details
DVL1LATS1BioGRID34079125 details
DVL1MAPRE3BioGRID34079125 details
DVL1OCLNBioGRID34079125 details
DVL1PARD3BioGRID34079125 details
DVL1PXNBioGRID34079125 details
DVL1SEPTIN10BioGRID34079125 details
DVL1HNRNPH1BioGRID26760575 details