Entity Details

Primary name PTK6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13882
EntryNamePTK6_HUMAN
FullNameProtein-tyrosine kinase 6
TaxID9606
Evidenceevidence at protein level
Length451
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesPTK6

GO terms

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GOName
GO:0001726 ruffle
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0009968 negative regulation of signal transduction
GO:0010976 positive regulation of neuron projection development
GO:0016477 cell migration
GO:0016604 nuclear body
GO:0030154 cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0038128 ERBB2 signaling pathway
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0045087 innate immune response
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045787 positive regulation of cell cycle
GO:0045926 negative regulation of growth
GO:0046777 protein autophosphorylation
GO:0060575 intestinal epithelial cell differentiation
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0071300 cellular response to retinoic acid

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035846 PTK6, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05294 VandetanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
PTK6_HUMANEGFR_HUMANBioGRID, HPRD, MINT16273093 22973453 8940083 details
PTK6_HUMANERBB3_HUMANBioGRID, HPRD, MINT11114724 16273093 22973453 details
PTK6_HUMANPTK6_HUMANBioGRID, DIP, HPRD, MINT12121988 15056653 18719096 19401189 26751287 31980649 details
PTK6_HUMANHD_HUMANIntAct17500595 32814053 details
PTK6_HUMANANDR_HUMANBioGRID, IntAct24728074 details
PTK6_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
PTK6_HUMANKIT_HUMANBioGRID, IntAct24728074 details
PTK6_HUMANMET_HUMANBioGRID, IntAct24728074 details
PTK6_HUMANERBB2_HUMANBioGRID, DIP, IntAct18719096 20700126 22973453 details
PTK6_HUMANWASL_HUMANBioGRID, IntAct25416956 details
PTK6_HUMANFCHO1_HUMANBioGRID, IntAct25416956 31515488 details
PTK6_HUMANREL_HUMANBioGRID, IntAct25416956 details
PTK6_HUMANEFHC2_HUMANBioGRID, IntAct25416956 31515488 32296183 details
PTK6_HUMANKHDR2_HUMANBioGRID, IntAct25416956 31515488 details
PTK6_HUMANEXOC5_HUMANBioGRID, IntAct25416956 32296183 details
PTK6_HUMANZN341_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANPRDM6_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANIKZF3_HUMANIntAct32296183 details
PTK6_HUMANANR55_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANSLAP1_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANDDX17_HUMANBioGRID, IntAct31980649 32296183 details
PTK6_HUMANCBLB_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANACTN3_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANMKRN3_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANDTX3_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANPITX1_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANMYOZ3_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANSKT_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANMEIS2_HUMANBioGRID, IntAct32296183 details
PTK6_HUMANCCD33_HUMANBioGRID, IntAct25416956 31515488 details
PTK6_HUMANKHDR1_HUMANBioGRID, HPRD, IntAct10913193 31980649 details
PTK6_HUMANSTAP2_HUMANBioGRID, HPRD10980601 details
PTK6_HUMANA4_HUMANBioGRID21832049 details
PTK6_HUMANFGFR1_HUMANBioGRID22974441 details
PTK6_HUMANDOK1_HUMANBioGRID22974441 details
PTK6_HUMANHIF1A_HUMANBioGRID23928995 26751287 details
PTK6_HUMANERBB4_HUMANBioGRID22973453 details
PTK6_HUMANSFPQ_HUMANMINT19439179 details
PTK6_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
PTK6_HUMANGPNMB_HUMANDIP26751287 details
PTK6_HUMANCDC37_HUMANBioGRID, IntAct31980649 details
PTK6_HUMANADA15_HUMANBioGRID18296648 details
PTK6_HUMANSOCS3_HUMANBioGRID22547065 details
PTK6_HUMANEPAS1_HUMANBioGRID23928995 details
PTK6_HUMANRPB1_HUMANBioGRID23928995 details