Entity Details

Primary name PTK2B
Entity type gene
Source Source Link

Details

PrimaryID2185
RefseqGeneNG_029510
SymbolPTK2B
Nameprotein tyrosine kinase 2 beta
Chromosome8
Location8p21.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-01-11
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsFAK2_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001556 oocyte maturation
GO:0001666 response to hypoxia
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002040 sprouting angiogenesis
GO:0002250 adaptive immune response
GO:0002315 marginal zone B cell differentiation
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004972 NMDA glutamate receptor activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006968 cellular defense response
GO:0006970 response to osmotic stress
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007229 integrin-mediated signaling pathway
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009612 response to mechanical stimulus
GO:0009725 response to hormone
GO:0009749 response to glucose
GO:0010226 response to lithium ion
GO:0010595 positive regulation of endothelial cell migration
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010752 regulation of cGMP-mediated signaling
GO:0010758 regulation of macrophage chemotaxis
GO:0010976 positive regulation of neuron projection development
GO:0014009 glial cell proliferation
GO:0014069 postsynaptic density
GO:0017146 NMDA selective glutamate receptor complex
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030027 lamellipodium
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030502 negative regulation of bone mineralization
GO:0030838 positive regulation of actin filament polymerization
GO:0031175 neuron projection development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031625 ubiquitin protein ligase binding
GO:0032960 regulation of inositol trisphosphate biosynthetic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035902 response to immobilization stress
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038110 interleukin-2-mediated signaling pathway
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042976 activation of Janus kinase activity
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043149 stress fiber assembly
GO:0043197 dendritic spine
GO:0043267 negative regulation of potassium ion transport
GO:0043423 3-phosphoinositide-dependent protein kinase binding
GO:0043507 positive regulation of JUN kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043534 blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045453 bone resorption
GO:0045471 response to ethanol
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045727 positive regulation of translation
GO:0045766 positive regulation of angiogenesis
GO:0045860 positive regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0048167 regulation of synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050848 regulation of calcium-mediated signaling
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060291 long-term synaptic potentiation
GO:0060292 long-term synaptic depression
GO:0065003 protein-containing complex assembly
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071300 cellular response to retinoic acid
GO:0071498 cellular response to fluid shear stress
GO:0086100 endothelin receptor signaling pathway
GO:0090630 activation of GTPase activity
GO:0097440 apical dendrite
GO:0098978 glutamatergic synapse
GO:2000058 regulation of ubiquitin-dependent protein catabolic process
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000114 regulation of establishment of cell polarity
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000310 regulation of NMDA receptor activity
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000538 positive regulation of B cell chemotaxis
GO:2000573 positive regulation of DNA biosynthetic process

Diseases

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Interactions

100 interactions

InteractorPartnerSourcesPublicationsLink
PTK2BRHOUIntAct18086875 details
PTK2BSRCBioGRID, HPRD, MINT10521452 10777553 11149930 19380485 8849729 details
PTK2BFYNBioGRID, HPRD, IntAct, MINT10229084 10867021 31413325 9091579 9104812 details
PTK2BNPHP1BioGRID, HPRD, IntAct11493697 21357692 details
PTK2BSKAP2BioGRID, IntAct12893833 31413325 details
PTK2BTGFB1I1BioGRID, HPRD, IntAct11856738 11937718 16330715 9422762 9858471 details
PTK2BPXNBioGRID, HPRD, IntAct10980697 11036077 31980649 9099734 9422762 details
PTK2BAPPIntAct32814053 details
PTK2BSORBS2BioGRID, HPRD15128873 details
PTK2BGSNBioGRID, HPRD12578912 details
PTK2BDLG3BioGRID, HPRD12576483 details
PTK2BDLG4BioGRID, HPRD12576483 details
PTK2BPTPN6BioGRID, HPRD10521452 10747947 details
PTK2BPTK2BBioGRID, HPRD11337490 11493697 17192257 9512511 9560226 details
PTK2BBCAR1BioGRID, HPRD11036077 12893833 8995252 9020138 details
PTK2BPITPNM3BioGRID, HPRD10022914 details
PTK2BPITPNM1BioGRID, HPRD10022914 details
PTK2BPITPNM2BioGRID, HPRD10022914 details
PTK2BASAP2BioGRID, HPRD10022920 details
PTK2BPTPN12BioGRID, HPRD11337490 12231407 15588985 details
PTK2BITGB3BioGRID, HPRD11683411 details
PTK2BPTPN11BioGRID, HPRD10880513 details
PTK2BRB1CC1BioGRID, HPRD10769033 details
PTK2BEWSR1BioGRID, HPRD10322114 details
PTK2BVAV1BioGRID, HPRD10867021 details
PTK2BRASA1BioGRID, HPRD10708762 10713673 details
PTK2BSOCS3BioGRID18507841 9344848 details
PTK2BMBD2BioGRID19661918 details
PTK2BSOCS2BioGRID20543098 details
PTK2BMAPTBioGRID17512525 details
PTK2BARHGAP21HPRD11238453 details
PTK2BASAP1HPRD12771146 details
PTK2BMAP3K4HPRD, MINT15601262 15881658 details
PTK2BPDCD6IPBioGRID, HPRD, MINT12771190 15557335 details
PTK2BEGFRBioGRID, HPRD, IntAct10777553 10980697 15657067 details
PTK2BMATKHPRD, MINT12063569 details
PTK2BGRB2BioGRID, HPRD, MINT10329689 10354709 19380485 8695788 details
PTK2BMYD88InnateDB22581261 details
PTK2BHSP90AB1IntAct22939624 details
PTK2BERBB2BioGRID, HPRD, IntAct10713673 25241761 details
PTK2BNPHP4UniProt15661758 details
PTK2BCLTCIntAct31413325 details
PTK2BCASS4IntAct31413325 details
PTK2BPHLPP1IntAct31413325 details
PTK2BEXOC6BIntAct31413325 details
PTK2BMCAMHPRD, IntAct11036077 31413325 details
PTK2BPAX6IntAct31413325 details
PTK2BCAMK2AIntAct31413325 details
PTK2BLPXNBioGRID, HPRD, IntAct31413325 9565592 details
PTK2BTRAF4BioGRID, IntAct16330715 20946164 details
PTK2BNCF1BioGRID, IntAct16330715 details
PTK2BCBLBioGRID, HPRD11149930 12771190 15128873 details
PTK2BGIT1BioGRID12629171 details
PTK2BGRIN2ABioGRID, HPRD11478920 12576483 details
PTK2BSYKBioGRID, HPRD10747947 details
PTK2BLCKBioGRID, HPRD9091579 details
PTK2BJAK3BioGRID, HPRD9512511 details
PTK2BJAK1BioGRID, HPRD10702271 details
PTK2BIL7RBioGRID, HPRD10702271 details
PTK2BKCNA2BioGRID, HPRD11739373 details
PTK2BLYNBioGRID, HPRD11311138 details
PTK2BNEDD9BioGRID, HPRD9020138 details
PTK2BJAK2BioGRID, HPRD11818507 details
PTK2BSLC2A1BioGRID, HPRD11007796 details
PTK2BPRKCDBioGRID, HPRD11352632 details
PTK2BGNA13BioGRID, HPRD10821841 details
PTK2BITGB2BioGRID, HPRD10961871 details
PTK2BTLN1BioGRID, HPRD9442086 details
PTK2BPTENBioGRID15717329 details
PTK2BSH3KBP1BioGRID12771190 details
PTK2BALG2BioGRID12771190 details
PTK2BDNM1BioGRID19380485 details
PTK2BGP6BioGRID20946164 details
PTK2BGP1BBBioGRID20946164 details
PTK2BCBLBBioGRID25099615 details
PTK2BERBB3BioGRID, HPRD15499613 27793840 details
PTK2BNEDD4LBioGRID27793840 details
PTK2BNEDD4BioGRID27793840 details
PTK2BPIK3R1BioGRID, HPRD10797305 15539082 details
PTK2BITGB1BioGRID15539082 details
PTK2BGRM1BioGRID20180987 details
PTK2BZAP70HPRD10867021 details
PTK2BSHC1HPRD7544443 details
PTK2BCCR5HPRD9446638 details
PTK2BEFSHPRD9750131 details
PTK2BARHGAP5HPRD10713673 details
PTK2BFGFR3HPRD15105428 details
PTK2BFLT1HPRD11751905 details
PTK2BPDPK1HPRD14585963 details
PTK2BSTAT3HPRD14963038 details
PTK2BSH2D3CHPRD12486027 details
PTK2BSTAP1HPRD10518561 details
PTK2BDLGAP3HPRD16202977 details
PTK2BMYH2HPRD10082674 details
PTK2BSNCAHPRD11162638 11744621 12096713 details
PTK2BCRKHPRD10329689 details
PTK2BPPP2R2BIntAct19156129 details
PTK2BDOCK8InnateDB22581261 details
PTK2BHSP90AA1BioGRID22939624 details
PTK2BVIRMABioGRID29507755 details