Entity Details

Primary name RAGE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15109
EntryNameRAGE_HUMAN
FullNameAdvanced glycosylation end product-specific receptor
TaxID9606
Evidenceevidence at protein level
Length404
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesAGER

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001650 fibrillar center
GO:0001666 response to hypoxia
GO:0001774 microglial cell activation
GO:0001914 regulation of T cell mediated cytotoxicity
GO:0001934 positive regulation of protein phosphorylation
GO:0004888 transmembrane signaling receptor activity
GO:0005044 scavenger receptor activity
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007611 learning or memory
GO:0009611 response to wounding
GO:0009986 cell surface
GO:0010255 glucose mediated signaling pathway
GO:0016324 apical plasma membrane
GO:0030054 cell junction
GO:0031175 neuron projection development
GO:0032693 negative regulation of interleukin-10 production
GO:0032722 positive regulation of chemokine production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0038023 signaling receptor activity
GO:0042104 positive regulation of activated T cell proliferation
GO:0042802 identical protein binding
GO:0043507 positive regulation of JUN kinase activity
GO:0044548 S100 protein binding
GO:0044877 protein-containing complex binding
GO:0045056 transcytosis
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0048143 astrocyte activation
GO:0048167 regulation of synaptic plasticity
GO:0050727 regulation of inflammatory response
GO:0050785 advanced glycation end-product receptor activity
GO:0050930 induction of positive chemotaxis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051101 regulation of DNA binding
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0072657 protein localization to membrane
GO:0090647 modulation of age-related behavioral decline
GO:0098794 postsynapse
GO:0150003 regulation of spontaneous synaptic transmission
GO:0150104 transport across blood-brain barrier
GO:1900271 regulation of long-term synaptic potentiation
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1900453 negative regulation of long-term synaptic depression
GO:1900744 regulation of p38MAPK cascade
GO:1900745 positive regulation of p38MAPK cascade
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903523 negative regulation of blood circulation
GO:1904472 positive regulation of endothelin production
GO:1904597 negative regulation of connective tissue replacement involved in inflammatory response wound healing
GO:1904645 response to amyloid-beta
GO:1904646 cellular response to amyloid-beta
GO:2000439 positive regulation of monocyte extravasation
GO:2000514 regulation of CD4-positive, alpha-beta T cell activation
GO:2001200 positive regulation of dendritic cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013162 CD80-like, immunoglobulin C2-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
RAGE_HUMANTTHY_HUMANHPRD, MINT16716307 details
RAGE_HUMANS100B_HUMANBioGRID, HPRD, MINT, UniProt10399917 17660747 17726019 21693575 details
RAGE_HUMANGRB2_HUMANBioGRID, IntAct17474147 21706016 details
RAGE_HUMANNCK1_HUMANIntAct17474147 details
RAGE_HUMANS10A1_HUMANHPRD, UniProt11007787 17726019 details
RAGE_HUMANRAGE_HUMANMINT24119142 details
RAGE_HUMANDIAP1_HUMANUniProt18922799 details
RAGE_HUMANHMGB1_HUMANBioGRID, HPRD, UniProt24474694 25495026 9812979 details
RAGE_HUMANCKLF7_HUMANBioGRID, IntAct32296183 details
RAGE_HUMANTTMP_HUMANBioGRID, IntAct32296183 details
RAGE_HUMANCREB3_HUMANBioGRID, IntAct25910212 details
RAGE_HUMANMAPK5_HUMANUniProt26758977 details
RAGE_HUMANS10A4_HUMANUniProt30083275 details
RAGE_HUMANCB015_HUMANIntAct32814053 details
RAGE_HUMANMIER1_HUMANIntAct32814053 details
RAGE_HUMANBDNF_HUMANIntAct32814053 details
RAGE_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
RAGE_HUMANS100P_HUMANBioGRID, HPRD, IntAct14617629 16061848 details
RAGE_HUMANRHOA_HUMANMINT19944695 details
RAGE_HUMANEGFR_HUMANDIP16954185 details
RAGE_HUMANKPCZ_HUMANIntAct21829704 details
RAGE_HUMANTIRAP_HUMANIntAct21829704 details
RAGE_HUMANSC61B_HUMANBioGRID10601334 details
RAGE_HUMANFGF2_HUMANBioGRID21693575 details
RAGE_HUMANFGFR1_HUMANBioGRID21693575 details
RAGE_HUMANRASK_HUMANBioGRID25341034 details
RAGE_HUMANFBXW7_HUMANBioGRID32124957 details
RAGE_HUMANFPR2_HUMANBioGRID23164356 details
RAGE_HUMANFPR1_HUMANBioGRID23164356 details
RAGE_HUMANS10AC_HUMANHPRD10399917 details