Entity Details

Primary name PDK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15119
EntryNamePDK2_HUMAN
FullName[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length407
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPDK2

GO terms

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GOName
GO:0004672 protein kinase activity
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005967 mitochondrial pyruvate dehydrogenase complex
GO:0006006 glucose metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006468 protein phosphorylation
GO:0006885 regulation of pH
GO:0008286 insulin receptor signaling pathway
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565 regulation of cellular ketone metabolic process
GO:0010906 regulation of glucose metabolic process
GO:0031670 cellular response to nutrient
GO:0034614 cellular response to reactive oxygen species
GO:0042593 glucose homeostasis
GO:0042803 protein homodimerization activity
GO:0050848 regulation of calcium-mediated signaling
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR005467 Histidine kinase domainDomainDomain
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminalDomainDomain
IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR039028 PDK/BCKDK protein kinaseFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08608 4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILEDrugbanksmall molecule
DB08609 (2R)-N-{4-[Ethyl(phenyl)sulfamoyl]-2-methylphenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamideDrugbanksmall molecule
DB08610 N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDEDrugbanksmall molecule