Entity Details

Primary name LTA
Entity type gene
Source Source Link

Details

PrimaryID4049
RefseqGeneNG_007462
SymbolLTA
Namelymphotoxin alpha
Chromosome6
Location6p21.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-02-20
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsTNFB_HUMAN

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007584 response to nutrient
GO:0032496 response to lipopolysaccharide
GO:0032729 positive regulation of interferon-gamma production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0048147 negative regulation of fibroblast proliferation
GO:0048535 lymph node development
GO:0050830 defense response to Gram-positive bacterium
GO:0060252 positive regulation of glial cell proliferation

Diseases

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Disease IDSourceNameDescription
607507 OMIMPsoriatic arthritis (PSORAS)An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Disease susceptibility is associated with variants affecting the gene represented in this entry.