Entity Details

Primary name MAP3K1
Entity type gene
Source Source Link

Details

PrimaryID4214
RefseqGeneNG_031884
SymbolMAP3K1
Namemitogen-activated protein kinase kinase kinase 1
Chromosome5
Location5q11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-15
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsM3K1_HUMAN

GO terms

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GOName
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Diseases

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Interactions

239 interactions

InteractorPartnerSourcesPublicationsLink
MAP3K1YWHAEBioGRID, IntAct, MINT14743216 9452471 details
MAP3K1MAP4K2BioGRID, IntAct11784851 9712898 details
MAP3K1MAP3K1BioGRID, IntAct11784851 12624112 14743216 details
MAP3K1DCAF7BioGRID, IntAct, MINT14743216 20940704 25342745 details
MAP3K1MAP2K4BioGRID, IntAct10713157 12228228 14500727 14581471 15299005 15866172 16472679 27806347 9808624 details
MAP3K1ESR1MINT15556606 details
MAP3K1IKBKBBioGRID, IntAct11057907 16286467 9819420 details
MAP3K1BRAFMINT16810323 16888650 details
MAP3K1TRAF2BioGRID, IntAct10346818 16636664 25241761 25260751 32041822 details
MAP3K1MAP2K7BioGRID, MINT14500727 15866172 17110930 details
MAP3K1UBE2D1BioGRID, IntAct19690564 details
MAP3K1UBE2D2BioGRID, IntAct19690564 details
MAP3K1UBE2D3BioGRID, IntAct19690564 details
MAP3K1UBE2D4BioGRID, IntAct19690564 details
MAP3K1UBE2E1BioGRID, IntAct19690564 details
MAP3K1UBE2L6BioGRID, IntAct19690564 details
MAP3K1UBE2WBioGRID, IntAct19690564 details
MAP3K1MAPK8BioGRID, IntAct12228228 14500727 15299005 21152872 25241761 9405400 details
MAP3K1MAPK3BioGRID, IntAct24135036 25241761 details
MAP3K1CHRM5BioGRID, MINT28298427 details
MAP3K1UBE2IBioGRID21336309 9563508 details
MAP3K1RAF1BioGRID, HPRD10969079 details
MAP3K1MAPK1BioGRID, HPRD10969079 14500727 14581471 24135036 details
MAP3K1GRB2BioGRID15192046 9733714 details
MAP3K1DTX1BioGRID15684388 details
MAP3K1RHOABioGRID14581471 21129722 24135036 details
MAP3K1ACTN1BioGRID14581471 details
MAP3K1ARHGAP4BioGRID14581471 details
MAP3K1MAPK9BioGRID12228228 14581471 details
MAP3K1CHUKBioGRID16286467 9689078 9819420 details
MAP3K1TP53BioGRID20923779 26018553 details
MAP3K1NFKBIABioGRID14500727 details
MAP3K1NR4A1BioGRID16434970 details
MAP3K1JUNBioGRID12796506 26237449 details
MAP3K1GSK3BBioGRID12584189 details
MAP3K1CRTC1BioGRID18784253 details
MAP3K1PAK1BioGRID12228228 details
MAP3K1BRCA1BioGRID22990118 details
MAP3K1BAP1BioGRID25260751 details
MAP3K1FKBP6BioGRID25260751 details
MAP3K1NPLOC4BioGRID25260751 details
MAP3K1ASCC2BioGRID25260751 details
MAP3K1UBE2V1BioGRID25260751 details
MAP3K1UBAC1BioGRID25260751 details
MAP3K1DNAJB6BioGRID25260751 details
MAP3K1TOM1L2BioGRID25260751 details
MAP3K1CUEDC1BioGRID25260751 details
MAP3K1HBS1LBioGRID25260751 details
MAP3K1APPL1BioGRID25260751 details
MAP3K1ZFAND5BioGRID25260751 details
MAP3K1TOM1BioGRID25260751 details
MAP3K1RAD23ABioGRID25260751 details
MAP3K1STAMBioGRID25260751 details
MAP3K1CD74BioGRID25260751 details
MAP3K1HIP1BioGRID25260751 details
MAP3K1UBXN7BioGRID25260751 details
MAP3K1HGSBioGRID25260751 details
MAP3K1ILRUNBioGRID25260751 details
MAP3K1RAB3IL1BioGRID25260751 details
MAP3K1UBASH3BBioGRID25260751 details
MAP3K1TAB1BioGRID25260751 details
MAP3K1DNAJB2BioGRID25260751 details
MAP3K1RNF141BioGRID25260751 details
MAP3K1MINDY3BioGRID25260751 details
MAP3K1UBAP1BioGRID25260751 details
MAP3K1DCUN1D1BioGRID25260751 details
MAP3K1NEK10BioGRID25260751 details
MAP3K1STAM2BioGRID25260751 details
MAP3K1GRIPAP1BioGRID25260751 details
MAP3K1EPHA1BioGRID25260751 details
MAP3K1RAD18BioGRID25260751 details
MAP3K1RBCK1BioGRID25260751 details
MAP3K1IMPACTBioGRID25260751 details
MAP3K1PSMD4BioGRID25260751 details
MAP3K1SPARTBioGRID25260751 details
MAP3K1ZFAND3BioGRID25260751 details
MAP3K1EPN1BioGRID25260751 details
MAP3K1RNF114BioGRID25260751 details
MAP3K1UBE2G1BioGRID25260751 details
MAP3K1DCUN1D2BioGRID25260751 details
MAP3K1UCHL5BioGRID25260751 details
MAP3K1CRELD1BioGRID25260751 details
MAP3K1ATXN3BioGRID25260751 details
MAP3K1FAF2BioGRID25260751 details
MAP3K1CEP85BioGRID25260751 details
MAP3K1UFD1BioGRID25260751 details
MAP3K1UBE2KBioGRID25260751 details
MAP3K1USP28BioGRID25260751 details
MAP3K1FAM184ABioGRID25260751 details
MAP3K1GGA2BioGRID25260751 details
MAP3K1PLEKHB2BioGRID25260751 details
MAP3K1KRT36BioGRID25260751 details
MAP3K1RNF126BioGRID25260751 details
MAP3K1APEX2BioGRID25260751 details
MAP3K1ODF2BioGRID25260751 details
MAP3K1DENND6BBioGRID25260751 details
MAP3K1CARD14BioGRID25260751 details
MAP3K1UBQLN1BioGRID25260751 details
MAP3K1CCDC69BioGRID25260751 details
MAP3K1RABEP2BioGRID25260751 details
MAP3K1RAD51AP1BioGRID25260751 details
MAP3K1TNIP1BioGRID25260751 details
MAP3K1MBPBioGRID12624112 details
MAP3K1COPS6BioGRID26237449 details
MAP3K1NOTCH1BioGRID27806347 details
MAP3K1BAALCBioGRID26050649 details
MAP3K1BAG2IntAct14743216 details
MAP3K1AIFM1IntAct14743216 details
MAP3K1CCT8IntAct14743216 details
MAP3K1HSPA1LBioGRID, IntAct14743216 25241761 details
MAP3K1HSPA5IntAct14743216 details
MAP3K1HSPA8IntAct14743216 details
MAP3K1RPS27LIntAct14743216 details
MAP3K1SLC25A5IntAct14743216 details
MAP3K1BAG5IntAct14743216 details
MAP3K1HSPA9IntAct14743216 details
MAP3K1MARS1IntAct14743216 details
MAP3K1RPLP2IntAct14743216 details
MAP3K1RUVBL2IntAct14743216 details
MAP3K1CCT5IntAct14743216 details
MAP3K1EPPK1IntAct14743216 details
MAP3K1HSPA6IntAct14743216 details
MAP3K1DNAJA1IntAct14743216 details
MAP3K1EEF1A2IntAct14743216 details
MAP3K1GLUD1IntAct14743216 details
MAP3K1TCP1IntAct14743216 details
MAP3K1SSR4IntAct14743216 details
MAP3K1SLC1A5IntAct14743216 details
MAP3K1MYH10IntAct14743216 details
MAP3K1CADIntAct14743216 details
MAP3K1IRS4IntAct14743216 details
MAP3K1ACTG1IntAct14743216 details
MAP3K1RPS6IntAct14743216 details
MAP3K1RPL3IntAct14743216 details
MAP3K1HADHBIntAct14743216 details
MAP3K1TIMM50IntAct14743216 details
MAP3K1LGALS3BPIntAct14743216 details
MAP3K1RPS11IntAct14743216 details
MAP3K1RPS14IntAct14743216 details
MAP3K1FASNIntAct14743216 details
MAP3K1CCT3IntAct14743216 details
MAP3K1CCT6AIntAct14743216 details
MAP3K1GEMIN4IntAct14743216 details
MAP3K1RCN2IntAct14743216 details
MAP3K1RPL35AIntAct14743216 details
MAP3K1RPL7IntAct14743216 details
MAP3K1TUBB2BIntAct14743216 details
MAP3K1HADHAIntAct14743216 details
MAP3K1TUBB6IntAct14743216 details
MAP3K1RPL14IntAct14743216 details
MAP3K1HSPBP1IntAct14743216 details
MAP3K1CALM1IntAct14743216 details
MAP3K1CALM2IntAct14743216 details
MAP3K1CALM3IntAct14743216 details
MAP3K1TUBB8IntAct14743216 details
MAP3K1TUBBIntAct14743216 details
MAP3K1TUBB4AIntAct14743216 details
MAP3K1RPS27IntAct14743216 details
MAP3K1DNAJA3IntAct14743216 details
MAP3K1FLNAIntAct14743216 details
MAP3K1DHX9IntAct14743216 details
MAP3K1RPL18IntAct14743216 details
MAP3K1RPL37AIntAct14743216 details
MAP3K1VIMIntAct14743216 details
MAP3K1UBBIntAct14743216 details
MAP3K1H4-16IntAct14743216 details
MAP3K1H4C15IntAct14743216 details
MAP3K1H4C9IntAct14743216 details
MAP3K1H4C1IntAct14743216 details
MAP3K1H4C4IntAct14743216 details
MAP3K1H4C6IntAct14743216 details
MAP3K1H4C12IntAct14743216 details
MAP3K1H4C11IntAct14743216 details
MAP3K1H4C3IntAct14743216 details
MAP3K1H4C8IntAct14743216 details
MAP3K1H4C2IntAct14743216 details
MAP3K1H4C5IntAct14743216 details
MAP3K1H4C13IntAct14743216 details
MAP3K1H4C14IntAct14743216 details
MAP3K1RPS8IntAct14743216 details
MAP3K1NOP2IntAct14743216 details
MAP3K1SLC25A6IntAct14743216 details
MAP3K1RPS4XIntAct14743216 details
MAP3K1NCLIntAct14743216 details
MAP3K1RPS23IntAct14743216 details
MAP3K1RPL35IntAct14743216 details
MAP3K1DDB1IntAct14743216 details
MAP3K1HSPH1IntAct14743216 details
MAP3K1TUBA3DIntAct14743216 details
MAP3K1TUBA3CIntAct14743216 details
MAP3K1RPL13IntAct14743216 details
MAP3K1HNRNPMIntAct14743216 details
MAP3K1RPL10AIntAct14743216 details
MAP3K1RPL10IntAct14743216 details
MAP3K1CCT4IntAct14743216 details
MAP3K1RPL24IntAct14743216 details
MAP3K1SNRPFIntAct14743216 details
MAP3K1HSP90AB1IntAct14743216 details
MAP3K1USP9XIntAct14743216 details
MAP3K1RPS9IntAct14743216 details
MAP3K1RPS16IntAct14743216 details
MAP3K1MYLK2IntAct14743216 details
MAP3K1MYO1DIntAct14743216 details
MAP3K1TUBA1AIntAct14743216 details
MAP3K1HSP90AA1IntAct14743216 details
MAP3K1UBCMINT16845370 details
MAP3K1MAP2K1BioGRID, MINT10969079 14500727 17110930 details
MAP3K1FLNBBioGRID, MINT19270716 details
MAP3K1AXIN1BioGRID, IntAct10829020 11884395 20128690 22682247 24135036 details
MAP3K1MAP4K4BioGRID9135144 details
MAP3K1DVL2BioGRID10829020 details
MAP3K1MAPK8IP3BioGRID10523642 details
MAP3K1ALKBioGRID14968112 details
MAP3K1GSTP1BioGRID16636664 details
MAP3K1YWHAQBioGRID21152872 details
MAP3K1YWHAGBioGRID21152872 details
MAP3K1STK38BioGRID17906693 29969578 details
MAP3K1TRIM5BioGRID21512573 details
MAP3K1KAT5BioGRID16469706 details
MAP3K1FRAT1BioGRID24135036 details
MAP3K1CD40BioGRID32041822 details
MAP3K1CDC37BioGRID, IntAct14743216 details
MAP3K1FKBP5BioGRID, IntAct14743216 details
MAP3K1RPL30BioGRID, IntAct14743216 details
MAP3K1RPL4BioGRID, IntAct14743216 details
MAP3K1RPS13BioGRID, IntAct14743216 details
MAP3K1ARRB1BioGRID, IntAct17620599 details
MAP3K1ARRB2BioGRID, IntAct17620599 25241761 details
MAP3K1HIPK2BioGRID, MINT20940704 details
MAP3K1DYRK1ABioGRID, MINT20940704 details
MAP3K1DYRK1BBioGRID, MINT20940704 details
MAP3K1MYCIntAct21150319 details
MAP3K1LLGL2BioGRID, IntAct26496610 details
MAP3K1NOP56BioGRID, IntAct26496610 details
MAP3K1HNRNPKBioGRID, IntAct30021884 details
MAP3K1NTRK1BioGRID25921289 details
MAP3K1XPO1BioGRID26673895 details
MAP3K1MCM2BioGRID25963833 details
MAP3K1VIRMABioGRID29507755 details