Entity Details

Primary name MLH1
Entity type gene
Source Source Link

Details

PrimaryID4292
RefseqGeneNG_007109
SymbolMLH1
NamemutL homolog 1
Chromosome3
Location3p22.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-20
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMLH1_HUMAN

GO terms

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GOName
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000712 resolution of meiotic recombination intermediates
GO:0000795 synaptonemal complex
GO:0001673 male germ cell nucleus
GO:0003682 chromatin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005712 chiasma
GO:0005715 late recombination nodule
GO:0006298 mismatch repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0007060 male meiosis chromosome segregation
GO:0007129 homologous chromosome pairing at meiosis
GO:0007283 spermatogenesis
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009617 response to bacterium
GO:0016020 membrane
GO:0016321 female meiosis chromosome segregation
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0032137 guanine/thymine mispair binding
GO:0032300 mismatch repair complex
GO:0032389 MutLalpha complex
GO:0043060 meiotic metaphase I plate congression
GO:0045141 meiotic telomere clustering
GO:0045190 isotype switching
GO:0045950 negative regulation of mitotic recombination
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048477 oogenesis
GO:0051257 meiotic spindle midzone assembly

Diseases

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Interactions

241 interactions

InteractorPartnerSourcesPublicationsLink
MLH1AP2B1BioGRID, HPRD, IntAct16189514 25910212 27107012 32296183 details
MLH1TRIM29BioGRID, HPRD, IntAct16189514 26095369 details
MLH1ZC3H11ABioGRID, HPRD, IntAct16189514 19060904 27229929 29892012 31515488 details
MLH1FRMD6BioGRID, HPRD, IntAct16189514 28514442 29892012 31515488 32296183 details
MLH1UBOX5BioGRID, HPRD, IntAct16189514 27229929 29892012 31515488 32296183 details
MLH1PMS2BioGRID, DIP, HPRD, IntAct, MINT10037723 10748159 11292842 11429708 11793469 12584560 12799449 12810663 14676842 15225546 16083711 17148452 17581638 18206974 18768816 19015241 20533529 20706999 20978114 22252508 22939629 25077178 25502805 26496610 30770470 31515488 details
MLH1BRIP1BioGRID, IntAct, MINT16391231 17148452 17581638 20173781 20978114 22792074 22968820 23585563 24573678 24966277 25502805 details
MLH1TMSB4XBioGRID, IntAct17967441 20706999 details
MLH1ZER1BioGRID, IntAct20706999 details
MLH1HSD17B3IntAct20706999 details
MLH1FLNCIntAct20706999 details
MLH1TPRG1LIntAct20706999 details
MLH1CUTAIntAct20706999 details
MLH1COPAIntAct20706999 details
MLH1CLIC1IntAct20706999 details
MLH1VPS51IntAct20706999 details
MLH1ACO2IntAct20706999 details
MLH1PTGDSBioGRID, IntAct20706999 details
MLH1VAMP8BioGRID, IntAct20706999 details
MLH1FCGBPBioGRID, IntAct20706999 details
MLH1ABCC3BioGRID, IntAct20706999 details
MLH1FBXO32BioGRID, IntAct20706999 details
MLH1SQSTM1BioGRID, IntAct20706999 details
MLH1AGR2BioGRID, IntAct20706999 details
MLH1EIF2ABioGRID, IntAct20706999 details
MLH1APRTBioGRID, IntAct20706999 details
MLH1ABHD16ABioGRID, IntAct20706999 details
MLH1EEF2BioGRID, IntAct20706999 details
MLH1LGALS4BioGRID, IntAct20706999 details
MLH1PARVABioGRID, IntAct20706999 details
MLH1SPTAN1BioGRID, IntAct20706999 26344197 details
MLH1MYL6BioGRID, IntAct20706999 details
MLH1CKAP4BioGRID, IntAct20706999 details
MLH1FLNBBioGRID, IntAct20706999 details
MLH1ACTG1BioGRID, IntAct20706999 details
MLH1ACTG2BioGRID, IntAct20706999 details
MLH1ANXA2BioGRID, IntAct20706999 details
MLH1DESBioGRID, IntAct20706999 details
MLH1TXN2BioGRID, IntAct20706999 details
MLH1MAP2K6BioGRID, IntAct20706999 details
MLH1NDRG1BioGRID, IntAct20706999 details
MLH1STAP2BioGRID, IntAct20706999 details
MLH1CAPN5BioGRID, IntAct20706999 details
MLH1CTSBBioGRID, IntAct20706999 details
MLH1GABARAPBioGRID, IntAct20706999 details
MLH1ARAFBioGRID, IntAct20706999 details
MLH1ANXA6BioGRID, IntAct20706999 details
MLH1AIFM1BioGRID, IntAct17148452 20706999 details
MLH1RAPGEFL1BioGRID, IntAct20706999 details
MLH1RAD23BBioGRID, IntAct20706999 details
MLH1PARP12BioGRID, IntAct20706999 details
MLH1TRIM23BioGRID, IntAct20706999 details
MLH1DDX47BioGRID, IntAct20706999 details
MLH1CAB39LBioGRID, IntAct20706999 details
MLH1ASS1BioGRID, IntAct20706999 details
MLH1CKBBioGRID, IntAct20706999 details
MLH1EXOC3BioGRID, IntAct20706999 details
MLH1ALDOABioGRID, IntAct20706999 details
MLH1SEC61A1BioGRID, IntAct20706999 details
MLH1SERPINF1BioGRID, IntAct20706999 details
MLH1SELENBP1BioGRID, IntAct20706999 details
MLH1GSTP1BioGRID, IntAct20706999 details
MLH1ACER3BioGRID, IntAct20706999 details
MLH1ELP6BioGRID, IntAct20706999 details
MLH1SLC25A23IntAct20706999 details
MLH1PTP4A2IntAct20706999 details
MLH1NT5C3BBioGRID, IntAct20706999 details
MLH1PLPP2IntAct20706999 details
MLH1PTPRHBioGRID, IntAct20706999 details
MLH1RPS5IntAct20706999 details
MLH1RRBP1IntAct20706999 details
MLH1RPS16IntAct20706999 details
MLH1NDUFS8IntAct20706999 details
MLH1NDFIP2IntAct20706999 details
MLH1NONOIntAct20706999 details
MLH1RPS2IntAct20706999 details
MLH1IL20RAIntAct20706999 details
MLH1NCF4IntAct20706999 details
MLH1BRCA1BioGRID, HPRD, MINT, UniProt10783165 16786532 17148452 21240188 25184681 29656893 details
MLH1RADXBioGRID, IntAct, MINT21516116 25416956 27229929 31515488 32296183 details
MLH1CBY2BioGRID, IntAct, MINT21516116 25416956 25910212 27107012 29892012 31515488 32296183 details
MLH1ATF2BioGRID, IntAct21988832 details
MLH1ORC4BioGRID, IntAct21988832 details
MLH1TXNBioGRID, IntAct21988832 details
MLH1ALDOBBioGRID, MINT24412244 details
MLH1BAATBioGRID, MINT24412244 details
MLH1TRMOBioGRID, MINT24412244 details
MLH1CTSVBioGRID, MINT24412244 details
MLH1CYLC2BioGRID, MINT24412244 details
MLH1FRAT2BioGRID, MINT24412244 details
MLH1CCDC180BioGRID, MINT24412244 details
MLH1LEF1BioGRID, MINT24412244 details
MLH1PPP2CBBioGRID, MINT24412244 details
MLH1SMAD1BioGRID, MINT24412244 details
MLH1STX17BioGRID, MINT24412244 details
MLH1TDRD7BioGRID, MINT24412244 details
MLH1XPABioGRID, MINT24412244 details
MLH1EXO1BioGRID, HPRD, IntAct, UniProt11427529 11429708 12414623 12810663 14676842 17148452 19015241 21533173 22222486 32814904 details
MLH1MSH3BioGRID, IntAct17148452 25416956 29892012 31515488 details
MLH1PSMA1BioGRID, IntAct25416956 29892012 31515488 details
MLH1MYOGBioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
MLH1KPNA2BioGRID, IntAct17148452 25416956 29892012 31515488 32296183 details
MLH1PMS1BioGRID, HPRD, IntAct10748159 11292842 17148452 20004149 25502805 26496610 details
MLH1FAN1BioGRID, IntAct17148452 20603015 20603073 25659891 26496610 27880917 29051491 32296183 details
MLH1CDKL5BioGRID, IntAct, MINT21653829 32296183 details
MLH1ZNF212BioGRID, IntAct32296183 details
MLH1NFIXBioGRID, IntAct32296183 details
MLH1AP1B1BioGRID, IntAct32296183 details
MLH1PER2BioGRID, IntAct32296183 details
MLH1PTPN3BioGRID, IntAct32296183 details
MLH1BTBD2BioGRID, IntAct32296183 details
MLH1RSPH3BioGRID, IntAct32296183 details
MLH1TFAP2DBioGRID, IntAct32296183 details
MLH1ZFP90BioGRID, IntAct32296183 details
MLH1NME4BioGRID, IntAct32296183 details
MLH1CCDC74BBioGRID, IntAct32296183 details
MLH1FAM228ABioGRID, IntAct32296183 details
MLH1SYF2BioGRID, IntAct32296183 details
MLH1ZNF559-ZNF177BioGRID, IntAct32296183 details
MLH1ZNF177BioGRID, IntAct32296183 details
MLH1FAM50BBioGRID, IntAct32296183 details
MLH1TLE5BioGRID, IntAct27229929 32296183 details
MLH1RBM48BioGRID, IntAct32296183 details
MLH1U2AF1L5BioGRID, IntAct32296183 details
MLH1U2AF1BioGRID, IntAct32296183 details
MLH1MORN3BioGRID, IntAct32296183 details
MLH1ISY1-RAB43IntAct32296183 details
MLH1ISY1BioGRID, IntAct32296183 details
MLH1NANOS3BioGRID, IntAct32296183 details
MLH1ZMAT5BioGRID, IntAct32296183 details
MLH1PRR5LBioGRID, IntAct32296183 details
MLH1MAGEA8BioGRID, IntAct25910212 27229929 32296183 details
MLH1CDCA7LBioGRID, IntAct27229929 32296183 details
MLH1TSGA13BioGRID, IntAct32296183 details
MLH1PPP1R13BBioGRID, IntAct32296183 details
MLH1MPGBioGRID, IntAct32296183 details
MLH1MBD4BioGRID, HPRD, IntAct10097147 25358258 32296183 details
MLH1TASOR2BioGRID, IntAct25910212 32296183 details
MLH1ENKD1BioGRID, IntAct32296183 details
MLH1KPRPBioGRID, IntAct32296183 details
MLH1C9orf152BioGRID, IntAct32296183 details
MLH1ZFP57BioGRID, IntAct32296183 details
MLH1MBD3L1BioGRID, IntAct32296183 details
MLH1LUC7L3BioGRID, IntAct32296183 details
MLH1NELFABioGRID, IntAct32296183 details
MLH1ZNF774BioGRID, IntAct32296183 details
MLH1PIP4K2BBioGRID, IntAct32296183 details
MLH1FAM90A1BioGRID, IntAct32296183 details
MLH1ZNF474BioGRID, IntAct32296183 details
MLH1MLH3BioGRID, HPRD, IntAct10615123 11292842 24443562 27229929 32814343 details
MLH1BLMBioGRID, HPRD10783165 11325959 11470874 11691925 12724401 19015241 21466675 details
MLH1MYCBioGRID, HPRD12584560 29467282 details
MLH1MSH4BioGRID, HPRD10928988 32814904 details
MLH1POLHBioGRID19703417 details
MLH1EEF1GBioGRID20706999 details
MLH1PCNABioGRID15225546 28439008 32814904 details
MLH1CCDC33BioGRID25910212 27229929 32296183 details
MLH1CEP76BioGRID27229929 details
MLH1CEP126BioGRID27229929 details
MLH1LY96BioGRID27229929 details
MLH1ZBED1BioGRID27229929 details
MLH1HDAC6BioGRID24882211 30770470 details
MLH1KPNA5BioGRID32296183 details
MLH1MSH5BioGRID32814904 details
MLH1FSCN1IntAct20603015 details
MLH1H2AXBioGRID, IntAct22094255 26095369 details
MLH1MSH2BioGRID, IntAct10748159 10783165 12799449 25241761 30770470 31843968 details
MLH1CASP3BioGRID, HPRD, IntAct15087450 25241761 details
MLH1HSPA8IntAct25502805 details
MLH1ATMBioGRID10783165 details
MLH1MRE11BioGRID10783165 details
MLH1MSH6BioGRID10748159 10783165 12799449 30770470 details
MLH1NBNBioGRID10783165 17121922 details
MLH1RAD50BioGRID10783165 details
MLH1RFC1BioGRID10783165 details
MLH1SMC1ABioGRID17148452 details
MLH1XRN1BioGRID17148452 details
MLH1PSD3BioGRID17148452 details
MLH1UBCBioGRID17148452 details
MLH1UBAP2LBioGRID17148452 details
MLH1YLPM1BioGRID17148452 details
MLH1PRKDCBioGRID17148452 details
MLH1KPNB1BioGRID17148452 details
MLH1RUVBL1BioGRID17148452 details
MLH1RUVBL2BioGRID17148452 details
MLH1PPP2R1ABioGRID17148452 details
MLH1PPP2R2ABioGRID17148452 details
MLH1PPP2R2BBioGRID17148452 details
MLH1PPP3CBBioGRID17148452 details
MLH1PPP3CCBioGRID17148452 details
MLH1PPP2R2DBioGRID17148452 details
MLH1PIK3C2ABioGRID17148452 details
MLH1AMOTBioGRID17148452 details
MLH1ATAD3ABioGRID17148452 details
MLH1DOCK7BioGRID17148452 details
MLH1PYGBBioGRID17148452 details
MLH1ATP5F1ABioGRID17148452 details
MLH1ATAD3BBioGRID17148452 details
MLH1WDR61BioGRID17148452 details
MLH1BARD1BioGRID16391231 details
MLH1FANCD2BioGRID21865299 details
MLH1SPRTNBioGRID23042605 details
MLH1MCM9BioGRID26300262 26870752 details
MLH1MCM8BioGRID26300262 details
MLH1SMARCAD1BioGRID31843968 details
MLH1RAD9AHPRD18842633 details
MLH1SNW1BioGRID, MINT20467437 details
MLH1TAGLNIntAct20706999 details
MLH1PLXNA3BioGRID, IntAct26496610 details
MLH1CTTNBioGRID, IntAct26496610 details
MLH1CAPZA2BioGRID, IntAct26496610 details
MLH1INO80BioGRID, IntAct26496610 details
MLH1FKBP8BioGRID, IntAct26496610 details
MLH1NANPBioGRID, IntAct26496610 details
MLH1HDLBPBioGRID, IntAct26496610 details
MLH1SLC25A1BioGRID, IntAct26496610 details
MLH1LYSTBioGRID, IntAct26496610 details
MLH1PSMD6BioGRID, IntAct26496610 details
MLH1HMGB1UniProt15014079 details
MLH1MAPTUniProt26269332 details
MLH1ESR1BioGRID, IntAct31527615 details
MLH1ENGBioGRID, UniProt31540324 details
MLH1MMS19BioGRID22678362 details
MLH1API5BioGRID26344197 details
MLH1SPTBN2BioGRID26344197 details
MLH1USP5BioGRID26344197 details
MLH1ZNF224BioGRID26344197 details
MLH1NTRK1BioGRID25921289 details
MLH1ELMO2BioGRID26496610 details
MLH1CDK9BioGRID27684187 details
MLH1CSNK1A1BioGRID27684187 details
MLH1NDUFB8BioGRID31536960 details
MLH1ELOBBioGRID31253590 details
MLH1PLEKHA4BioGRID31091453 details
MLH1TRIM66BioGRID31753913 details
MLH1TERF2IPBioGRID34079125 details
MLH1SIRT1IntAct22094255 details
MLH1DNMT1IntAct22094255 details
MLH1DNMT3BIntAct22094255 details
MLH1EZH2IntAct22094255 details
MLH1APEX1BioGRID28986522 details