Entity Details

Primary name CYTB
Entity type gene
Source Source Link

Details

PrimaryID4519
RefseqGene
SymbolCYTB
Namemitochondrially encoded cytochrome b
Chromosome
Location
TaxID9606
Statuslive
SourceGenomemitochondrion
SourceOrigin
CreationDate2003-08-05
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsCYB_HUMAN

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005750 mitochondrial respiratory chain complex III
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0009408 response to heat
GO:0009636 response to toxic substance
GO:0015990 electron transport coupled proton transport
GO:0031100 animal organ regeneration
GO:0031305 integral component of mitochondrial inner membrane
GO:0033590 response to cobalamin
GO:0033762 response to glucagon
GO:0042493 response to drug
GO:0042538 hyperosmotic salinity response
GO:0044877 protein-containing complex binding
GO:0045471 response to ethanol
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0046689 response to mercury ion
GO:0046872 metal ion binding
GO:0051592 response to calcium ion
GO:0055093 response to hyperoxia

Diseases

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Disease IDSourceNameDescription
535000 OMIMLeber hereditary optic neuropathy (LHON)A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry.
500000 OMIMCardiomyopathy, infantile histiocytoid (CMIH)A heart disease characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome. The disease is caused by variants affecting the gene represented in this entry.

Interactions

10 interactions

InteractorPartnerSourcesPublicationsLink
CYTBMVPBioGRID, IntAct21988832 details
CYTBKRASBioGRID, MINT25640309 details
CYTBNDUFA9BioGRID, MINT24344204 details
CYTBMRPL50BioGRID, IntAct28514442 details
CYTBUQCRHBioGRID, IntAct28514442 details
CYTBUQCRBBioGRID, IntAct26186194 28514442 details
CYTBUQCRQBioGRID, IntAct28514442 details
CYTBCLDND1BioGRID, IntAct28514442 details
CYTBCYC1BioGRID26344197 details
CYTBUQCRFS1BioGRID26344197 details