Entity Details

Primary name PDE4D
Entity type gene
Source Source Link

Details

PrimaryID5144
RefseqGeneNG_027957
SymbolPDE4D
Namephosphodiesterase 4D
Chromosome5
Location5q11.2-q12.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-07-29
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsPDE4D_HUMAN

GO terms

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GOName
GO:0002027 regulation of heart rate
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010469 regulation of signaling receptor activity
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019899 enzyme binding
GO:0019933 cAMP-mediated signaling
GO:0030552 cAMP binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032754 positive regulation of interleukin-5 production
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034704 calcium channel complex
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0044325 transmembrane transporter binding
GO:0045822 negative regulation of heart contraction
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0051117 ATPase binding
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028 establishment of endothelial barrier
GO:0071320 cellular response to cAMP
GO:0071872 cellular response to epinephrine stimulus
GO:0071875 adrenergic receptor signaling pathway
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086024 adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate
GO:0097110 scaffold protein binding
GO:1901363 heterocyclic compound binding
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898 negative regulation of relaxation of cardiac muscle

Diseases

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Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
PDE4DARRB2BioGRID, DIP, IntAct, MINT14500724 17620599 19955404 20664520 details
PDE4DPRKACABioGRID, HPRD, MINT20196770 20664520 8663227 9639573 details
PDE4DZDHHC17BioGRID, IntAct24705354 details
PDE4DCOILBioGRID, IntAct25416956 32296183 details
PDE4DMAGEA6BioGRID, IntAct25416956 details
PDE4DTRAF1BioGRID, IntAct25416956 details
PDE4DPCNAUniProt26030842 details
PDE4DOPTNIntAct32814053 details
PDE4DPDE4DIPBioGRID, HPRD11134006 details
PDE4DPDE4DBioGRID, HPRD12387865 details
PDE4DRACK1BioGRID, HPRD10329691 11516626 12193273 19372219 details
PDE4DARRB1BioGRID14500724 19372219 details
PDE4DMDM2BioGRID19372219 details
PDE4DITSN1BioGRID22558309 details
PDE4DGSK3BBioGRID20647544 details
PDE4DCSNK1A1BioGRID20647544 details
PDE4DPAFAH1B1BioGRID21652625 details
PDE4DAPPBioGRID21832049 details
PDE4DLYNBioGRID10571082 details
PDE4DSRCBioGRID10571082 details
PDE4DFYNBioGRID10571082 details
PDE4DABL1BioGRID10571082 details
PDE4DGRB2BioGRID10571082 details
PDE4DPIAS4BioGRID20196770 details
PDE4DMAPK1BioGRID20196770 details
PDE4DSPTAN1BioGRID10571082 details
PDE4DPIK3R1BioGRID10571082 details
PDE4DTRIM23BioGRID21516116 details
PDE4DFBXO7BioGRID27503909 details
PDE4DHRASBioGRID30655611 details
PDE4DAKAP12BioGRID, MINT16642035 details
PDE4DSHANK2IntAct17244609 details
PDE4DAKAP6BioGRID, HPRD11296225 details
PDE4DPPP3CABioGRID20647544 details
PDE4DPPP3CBBioGRID20647544 details
PDE4DPPP3R1BioGRID20647544 details
PDE4DZBTB1BioGRID24657165 details
PDE4DATOH1BioGRID27542412 details
PDE4DRXFP1MINT20664520 details
PDE4DAKAP5MINT20664520 details
PDE4DITPKBBioGRID, IntAct26496610 details
PDE4DPFKFB2BioGRID, IntAct26496610 details
PDE4DPDE4BBioGRID, IntAct28514442 details
PDE4DRYR1DIP18268335 details
PDE4DCDK2BioGRID21319273 details
PDE4DBIN1BioGRID22863883 details
PDE4DHDGFL2BioGRID22863883 details
PDE4DDUSP13BioGRID27432908 details
PDE4DPLK1BioGRID25659891 details
PDE4DLRRC31BioGRID33005030 details
PDE4DTRIM25BioGRID29117863 details
PDE4DHNRNPLBioGRID28611215 details
PDE4DVIRMABioGRID29507755 details
PDE4DMKRN2BioGRID32460013 details