Entity Details

Primary name DDR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16832
EntryNameDDR2_HUMAN
FullNameDiscoidin domain-containing receptor 2
TaxID9606
Evidenceevidence at protein level
Length855
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDDR2

GO terms

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GOName
GO:0001503 ossification
GO:0003416 endochondral bone growth
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005518 collagen binding
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0010715 regulation of extracellular matrix disassembly
GO:0010763 positive regulation of fibroblast migration
GO:0015629 actin cytoskeleton
GO:0016324 apical plasma membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030500 regulation of bone mineralization
GO:0031214 biomineral tissue development
GO:0033674 positive regulation of kinase activity
GO:0034103 regulation of tissue remodeling
GO:0035988 chondrocyte proliferation
GO:0038062 protein tyrosine kinase collagen receptor activity
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
GO:0043235 receptor complex
GO:0045669 positive regulation of osteoblast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046777 protein autophosphorylation
GO:0048146 positive regulation of fibroblast proliferation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0090091 positive regulation of extracellular matrix disassembly

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000421 Coagulation factor 5/8 C-terminal domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR034299 Discoidin domain-containing receptor 1/2FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08896 RegorafenibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule