Entity Details

Primary name BAX
Entity type gene
Source Source Link

Details

PrimaryID581
RefseqGeneNG_012191
SymbolBAX
NameBCL2 associated X, apoptosis regulator
Chromosome19
Location19q13.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1997-11-18
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsBAX_HUMAN

GO terms

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GOName
GO:0001541 ovarian follicle development
GO:0001764 neuron migration
GO:0001777 T cell homeostatic proliferation
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001822 kidney development
GO:0001836 release of cytochrome c from mitochondria
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001974 blood vessel remodeling
GO:0002262 myeloid cell homeostasis
GO:0002352 B cell negative selection
GO:0002358 B cell homeostatic proliferation
GO:0002904 positive regulation of B cell apoptotic process
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005757 mitochondrial permeability transition pore complex
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006687 glycosphingolipid metabolic process
GO:0006808 regulation of nitrogen utilization
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007281 germ cell development
GO:0008053 mitochondrial fusion
GO:0008289 lipid binding
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008637 apoptotic mitochondrial changes
GO:0009566 fertilization
GO:0009636 response to toxic substance
GO:0009651 response to salt stress
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0010332 response to gamma radiation
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0015267 channel activity
GO:0016020 membrane
GO:0016032 viral process
GO:0021854 hypothalamus development
GO:0021987 cerebral cortex development
GO:0030544 Hsp70 protein binding
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032091 negative regulation of protein binding
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0032976 release of matrix enzymes from mitochondria
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0034620 cellular response to unfolded protein
GO:0034644 cellular response to UV
GO:0035234 ectopic germ cell programmed cell death
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045136 development of secondary sexual characteristics
GO:0046666 retinal cell programmed cell death
GO:0046930 pore complex
GO:0046982 protein heterodimerization activity
GO:0048087 positive regulation of developmental pigmentation
GO:0048147 negative regulation of fibroblast proliferation
GO:0048515 spermatid differentiation
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0048678 response to axon injury
GO:0048873 homeostasis of number of cells within a tissue
GO:0051087 chaperone binding
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051402 neuron apoptotic process
GO:0051434 BH3 domain binding
GO:0051881 regulation of mitochondrial membrane potential
GO:0060011 Sertoli cell proliferation
GO:0060041 retina development in camera-type eye
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0060068 vagina development
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070062 extracellular exosome
GO:0070242 thymocyte apoptotic process
GO:0070584 mitochondrion morphogenesis
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097136 Bcl-2 family protein complex
GO:0097144 BAX complex
GO:0097145 BAK complex
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0098586 cellular response to virus
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:1902512 positive regulation of apoptotic DNA fragmentation
GO:1903896 positive regulation of IRE1-mediated unfolded protein response
GO:1990117 B cell receptor apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

119 interactions

InteractorPartnerSourcesPublicationsLink
BAXBAXBioGRID, DIP, IntAct, MINT10620504 11161816 14963330 1558161 17074758 17289999 17668322 18547146 18835031 19062087 19074440 19767770 20360684 20850011 21712378 22198199 23374347 details
BAXBCL2BioGRID, DIP, HPRD, IntAct, MINT10620799 10716992 14980220 15231068 15899854 16642033 17097560 17289999 17525735 18981409 21199865 21458670 21671007 21778226 22262057 23479509 24141421 26004684 29749471 32064756 8358790 9111042 9388232 9463381 details
BAXBCL2L1BioGRID, DIP, HPRD, IntAct, MINT11283018 12137781 12853473 14963330 15131699 16151013 17289999 17525735 18547146 18981409 19074440 19427863 21199865 21458670 21567405 21671007 21852238 24814347 25115399 25241761 26186194 26496610 27684187 28202514 28514442 28760928 29749471 32064756 9027312 9111042 9153240 9388232 9742125 9824152 details
BAXMCL1BioGRID, DIP, HPRD, IntAct, MINT10837489 15077116 17525735 18981409 19148187 19968986 21199865 21458670 21566062 26186194 28514442 details
BAXBCL2L11BioGRID, DIP, IntAct, MINT17289999 17525735 18948948 19427863 21199865 23235460 23374347 26186194 details
BAXIRF3MINT20360684 details
BAXBCL2L2BioGRID, DIP, IntAct10381646 17289999 18981409 21199865 25115399 28514442 details
BAXSH3GLB1BioGRID, HPRD, IntAct11161816 11259440 19074440 details
BAXERN1HPRD, IntAct16645094 details
BAXBIDBioGRID, DIP, HPRD, IntAct15574335 17289999 20956295 23374347 25241761 details
BAXUHRF2BioGRID, UniProt21952639 details
BAXTP53BioGRID, IntAct17906639 25115399 25241761 32064756 details
BAXSNCABioGRID, IntAct25241761 32814053 details
BAXANP32BBioGRID, MINT24412244 details
BAXLEF1BioGRID, MINT24412244 details
BAXMAP2K1BioGRID, MINT24412244 details
BAXAKT1MINT26763134 details
BAXHSF2BPBioGRID, IntAct32296183 details
BAXBCL2L12BioGRID, IntAct26186194 28514442 29749471 details
BAXKCNA3BioGRID, DIP, HPRD18818304 20114030 details
BAXGSK3BDIP20080742 details
BAXBCL2A1BioGRID, HPRD10753914 details
BAXVDAC1BioGRID, HPRD12767928 15637055 28760928 9843949 details
BAXYWHAQBioGRID, HPRD12426317 details
BAXSLC25A4BioGRID, HPRD9748162 details
BAXPARK7BioGRID21852238 details
BAXCRYAABioGRID14752512 details
BAXCRYABBioGRID14752512 details
BAXYWHABBioGRID22785534 details
BAXZBTB24BioGRID19074440 details
BAXBBC3HPRD15574335 details
BAXSFNHPRD, MINT11574543 details
BAXBAK1BioGRID, HPRD, IntAct, MINT11571294 15901672 16439990 17289999 21712378 details
BAXPRKCEIntAct17668322 details
BAXBADBioGRID, MINT17274640 19427863 details
BAXRNF144BBioGRID, MINT20300062 details
BAXTOMM20MINT20300062 details
BAXUVRAGBioGRID, MINT21597469 30686098 details
BAXXRCC6BioGRID, UniProt15205477 19118032 19177010 19247369 21042904 25299772 details
BAXPYCARDUniProt14730312 details
BAXVRK2IntAct23449449 details
BAXBCL2L10BioGRID, HPRD, IntAct11278245 23235460 details
BAXRTL10IntAct23055042 details
BAXPMAIP1BioGRID, HPRD15705586 details
BAXHSPD1BioGRID12070120 details
BAXMOAP1BioGRID, HPRD11060313 details
BAXTOMM40BioGRID17635912 details
BAXTOMM22BioGRID17635912 details
BAXPSMC3BioGRID20431057 details
BAXPSMC5BioGRID20431057 details
BAXHDAC6BioGRID21847364 details
BAXXRCC5BioGRID19177010 details
BAXCLUBioGRID16113678 19118032 19177010 21567405 23538443 details
BAXXIAPBioGRID21712378 details
BAXHSPA4BioGRID15388581 details
BAXCASP9BioGRID15254227 details
BAXCASP8BioGRID15254227 details
BAXCASP7BioGRID15254227 details
BAXCASP3BioGRID15254227 details
BAXCYCSBioGRID15254227 details
BAXGIMAP5BioGRID16509771 details
BAXLRRK2BioGRID24991765 details
BAXND5BioGRID25115399 details
BAXFGFR1BioGRID18022941 details
BAXPRKNBioGRID28760928 32929329 details
BAXMAPK8BioGRID19910452 details
BAXITCHBioGRID32690868 details
BAXNOL3HPRD15383280 details
BAXPPP1CAHPRD17274640 details
BAXATPAF1MINT19968986 details
BAXYY1BioGRID, IntAct26496610 details
BAXBDP1BioGRID, IntAct26496610 details
BAXERCC6BioGRID, IntAct26496610 details
BAXPNPLA6BioGRID, IntAct26496610 details
BAXEDRF1BioGRID, IntAct26496610 details
BAXSERPINB12BioGRID, IntAct26496610 details
BAXNINBioGRID, IntAct26496610 details
BAXATAD5BioGRID, IntAct26496610 details
BAXNSFL1CBioGRID, IntAct26496610 details
BAXPRSS23BioGRID, IntAct26496610 details
BAXLIG3BioGRID, IntAct26496610 details
BAXGEMIN2BioGRID, IntAct26496610 details
BAXC18orf21BioGRID, IntAct26496610 details
BAXHSCBBioGRID, IntAct28380382 details
BAXBCL2L15BioGRID, IntAct28514442 details
BAXHSD17B10BioGRID, IntAct29128334 details
BAXC15orf48BioGRID, IntAct27499296 details
BAXFAM136AIntAct27499296 details
BAXCOQ9BioGRID, IntAct27499296 details
BAXMEPCEBioGRID17643375 details
BAXVCPBioGRID23383273 details
BAXBAG3BioGRID23824909 details
BAXPKMBioGRID26344197 details
BAXPCBP1BioGRID26344197 details
BAXPRDX1BioGRID26344197 details
BAXPRDX2BioGRID26344197 details
BAXSERPINH1BioGRID26344197 details
BAXOCIAD1BioGRID27499296 32877691 details
BAXPPM1JBioGRID27880917 details
BAXTRIM14BioGRID29053956 details
BAXRNF4BioGRID29180619 details
BAXESR2BioGRID29509190 details
BAXVIRMABioGRID29507755 details
BAXANAPC4BioGRID29549242 details
BAXLONRF3BioGRID31536960 details
BAXGUK1BioGRID31536960 details
BAXTXN2BioGRID31536960 details
BAXFCGRTBioGRID31536960 details
BAXGSTK1BioGRID31536960 details
BAXCLUAP1BioGRID29615496 details
BAXLMBR1LBioGRID31073040 details
BAXSLC25A46BioGRID32877691 details
BAXCOPS5BioGRID31950832 details
BAXWDR76BioGRID31353912 details
BAXAKAP1BioGRID34079125 details
BAXBRD7IntAct20228809 details
BAXPIN1IntAct17906639 details
BAXTRIM25BioGRID29117863 details
BAXMKRN2BioGRID32460013 details