Entity Details

Primary name STK4
Entity type gene
Source Source Link

Details

PrimaryID6789
RefseqGeneNG_032172
SymbolSTK4
Nameserine/threonine kinase 4
Chromosome20
Location20q13.12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSTK4_HUMAN

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000902 cell morphogenesis
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001841 neural tube formation
GO:0001934 positive regulation of protein phosphorylation
GO:0003157 endocardium development
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0016604 nuclear body
GO:0018105 peptidyl-serine phosphorylation
GO:0030216 keratinocyte differentiation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032092 positive regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043539 protein serine/threonine kinase activator activity
GO:0045600 positive regulation of fat cell differentiation
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0050821 protein stabilization
GO:0060215 primitive hemopoiesis
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0060800 regulation of cell differentiation involved in embryonic placenta development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097284 hepatocyte apoptotic process
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process

Diseases

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Interactions

211 interactions

InteractorPartnerSourcesPublicationsLink
STK4RASSF5BioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections11864565 15109305 16892067 17517604 20562859 20920251 23455922 24255178 24366813 24981860 details
STK4RASSF1BioGRID, HPRD, IntAct, MINT, Molecular Connections14729613 15109305 17598981 20562859 20920251 23386615 23455922 24255178 24366813 24981860 26186194 26578655 28205554 28514442 details
STK4STK4BioGRID, DIP, HPRD, IntAct11278782 12223493 17517604 20562859 21572393 22863277 23386615 26578655 28205554 8702870 details
STK4SAV1BioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections16930133 17517604 20562859 20920251 23386615 23455922 24255178 24366813 24981860 25692647 26186194 27173435 28514442 30266805 unassigned1312 details
STK4AKT1BioGRID, MINT17932490 details
STK4RASSF2BioGRID, IntAct, MINT, Molecular Connections20562859 20920251 23386615 23455922 24255178 24366813 24981860 26186194 28514442 details
STK4RASSF3BioGRID, IntAct, Molecular Connections20920251 23455922 24255178 24366813 details
STK4RASSF4BioGRID, IntAct, Molecular Connections20562859 20920251 23455922 24366813 details
STK4RASSF6BioGRID, IntAct, Molecular Connections20920251 24366813 26186194 28514442 details
STK4STK3BioGRID, IntAct, MINT, Molecular Connections20562859 20920251 23386615 23455922 24255178 24366813 24981860 26344197 28205554 details
STK4GABARAPBioGRID, IntAct20562859 31857374 details
STK4GABARAPL1IntAct20562859 details
STK4GABARAPL2IntAct20562859 details
STK4MAP1LC3BBioGRID, IntAct20562859 31857374 details
STK4MAP1LC3CIntAct20562859 details
STK4IL2RGBioGRID, IntAct21988832 details
STK4MOB1ABioGRID, I2D, IntAct21516123 23386615 24255178 31941533 details
STK4MOB1BBioGRID, IntAct22863277 24255178 details
STK4SLMAPBioGRID, IntAct23386615 24255178 24366813 details
STK4THAP12BioGRID, HPRD, IntAct12384512 24255178 details
STK4PRDX1IntAct23386615 details
STK4PIH1D1IntAct23386615 details
STK4PARVBIntAct23386615 details
STK4UBBIntAct23386615 details
STK4CSRP2IntAct23386615 details
STK4SPATA5L1IntAct23386615 details
STK4SOD2IntAct23386615 details
STK4PICK1BioGRID, IntAct32296183 details
STK4DDIT4LBioGRID, IntAct32296183 details
STK4FOXO1DIP18786403 details
STK4H2BC21BioGRID12757711 21572393 details
STK4SIRT1BioGRID21212262 details
STK4ABL1BioGRID21715626 details
STK4H2AXBioGRID20921231 details
STK4NEDD4BioGRID19953087 details
STK4SGMS1BioGRID22863277 details
STK4LATS2BioGRID24255178 26578655 26898830 30266805 30865227 details
STK4DAXXBioGRID21572393 details
STK4KEAP1BioGRID30765703 details
STK4RNF31BioGRID30901564 details
STK4MARK2BioGRID31080060 details
STK4OGTBioGRID32994395 details
STK4YWHAGIntAct17353931 details
STK4TP53BioGRID, HPRD, IntAct12384512 12942774 25241761 details
STK4CASP3BioGRID, HPRD, IntAct11278283 11278782 25241761 9545236 details
STK4LATS1HPRD, IntAct15688006 24012335 details
STK4HSPA8BioGRID, IntAct23386615 26657153 details
STK4KIF3BBioGRID, IntAct27173435 unassigned1312 details
STK4KIF3CBioGRID, IntAct27173435 unassigned1312 details
STK4AKAP12BioGRID, IntAct27173435 unassigned1312 details
STK4DYRK2BioGRID, IntAct27173435 unassigned1312 details
STK4FYNIntAct31413325 details
STK4CNKSR1BioGRID, HPRD15075335 details
STK4FOXO3BioGRID21715626 details
STK4CTTNBP2NLBioGRID24255178 details
STK4FBXW11BioGRID25332235 25515538 25900982 details
STK4LAMTOR5BioGRID26657153 details
STK4HDAC6BioGRID26657153 details
STK4CUL7BioGRID29632206 32252802 details
STK4TRAF6BioGRID30673917 details
STK4AMOTBioGRID30266805 details
STK4CSN1S1HPRD7665586 details
STK4MBPHPRD7665586 details
STK4SLX4IPBioGRID, IntAct19596235 details
STK4MAP1LC3ABioGRID, IntAct20562859 details
STK4TAOK1BioGRID, IntAct20562859 details
STK4MAP1BBioGRID, IntAct20562859 23455922 24366813 details
STK4SQSTM1IntAct20562859 details
STK4ERC1BioGRID, IntAct23455922 details
STK4CDK3BioGRID, IntAct23455922 details
STK4MAP1SBioGRID, IntAct23455922 24255178 24366813 details
STK4CUL5BioGRID, IntAct21145461 details
STK4STRNBioGRID, IntAct24255178 24366813 details
STK4XPO6BioGRID, IntAct24366813 details
STK4ANXA1BioGRID, IntAct23386615 24366813 details
STK4VAPABioGRID, IntAct24366813 28514442 details
STK4CDC37BioGRID, IntAct24366813 details
STK4KIF2ABioGRID, IntAct24255178 details
STK4AURKBBioGRID, IntAct24255178 details
STK4KIF2CBioGRID, IntAct24255178 details
STK4FGFR1OP2BioGRID, IntAct24255178 details
STK4SH3GLB2BioGRID, IntAct24255178 details
STK4MOB4BioGRID, IntAct24255178 details
STK4STRN3BioGRID, IntAct24255178 details
STK4STRN4BioGRID, IntAct24255178 details
STK4SNX5BioGRID, IntAct24255178 details
STK4STRIP1BioGRID, IntAct24255178 details
STK4RAB8ABioGRID, IntAct24255178 details
STK4PKMIntAct23386615 24606918 details
STK4EGLN3BioGRID, IntAct26972000 details
STK4TUBB6IntAct23386615 details
STK4MCCC2IntAct23386615 details
STK4LTFIntAct23386615 details
STK4ZRSR2IntAct23386615 details
STK4ALBIntAct23386615 details
STK4FLGIntAct23386615 details
STK4HSPA1AIntAct23386615 details
STK4HSPA1BIntAct23386615 details
STK4HSP90AA1IntAct23386615 details
STK4TUBA1CIntAct23386615 details
STK4COA1IntAct23386615 details
STK4HSPA9IntAct23386615 details
STK4AZGP1IntAct23386615 details
STK4HSPA5IntAct23386615 details
STK4TUBA3DIntAct23386615 details
STK4TUBA3CIntAct23386615 details
STK4HSPA2IntAct23386615 details
STK4HSPA6IntAct23386615 details
STK4TUBB1IntAct23386615 details
STK4HSPB1IntAct23386615 details
STK4H1-2IntAct23386615 details
STK4MCCC1IntAct23386615 details
STK4TGM3IntAct23386615 details
STK4CALML5IntAct23386615 details
STK4HALIntAct23386615 details
STK4ACTBL2IntAct23386615 details
STK4EEF1A2IntAct23386615 details
STK4GGCTIntAct23386615 details
STK4TUBB4BIntAct23386615 details
STK4HSPA1LIntAct23386615 details
STK4LCN1IntAct23386615 details
STK4SMR3BIntAct23386615 details
STK4NCCRP1IntAct23386615 details
STK4TUBA4AIntAct23386615 details
STK4PIGRIntAct23386615 details
STK4ACACAIntAct23386615 details
STK4JCHAINIntAct23386615 details
STK4GAPDHIntAct23386615 details
STK4HUWE1IntAct23386615 details
STK4EIF3CLIntAct23386615 details
STK4PHGDHIntAct23386615 details
STK4COPAIntAct23386615 details
STK4MSH2IntAct23386615 details
STK4FEN1IntAct23386615 details
STK4RANGAP1IntAct23386615 details
STK4COPG1IntAct23386615 details
STK4ARF4IntAct23386615 details
STK4MCM4IntAct23386615 details
STK4IPO5IntAct23386615 details
STK4MCM3IntAct23386615 details
STK4ARHGAP18IntAct23386615 details
STK4RPS18IntAct23386615 details
STK4PTBP1IntAct23386615 details
STK4SPTAN1IntAct23386615 details
STK4SNRNP200IntAct23386615 details
STK4CCT8IntAct23386615 details
STK4CCT3IntAct23386615 details
STK4CSE1LIntAct23386615 details
STK4SRP54IntAct23386615 details
STK4DUSP9IntAct23386615 details
STK4MAP2K4IntAct23386615 details
STK4RANBP2IntAct23386615 details
STK4XPO1BioGRID, IntAct23386615 26673895 details
STK4SULT1A1IntAct23386615 details
STK4MSH6IntAct23386615 details
STK4XRCC5IntAct23386615 details
STK4RPL4IntAct23386615 details
STK4CAND1IntAct23386615 details
STK4ILKIntAct23386615 details
STK4KPNB1IntAct23386615 details
STK4CTNNB1IntAct23386615 details
STK4IPO7IntAct23386615 details
STK4CKAP5IntAct23386615 details
STK4ARHGAP1IntAct23386615 details
STK4RPS3IntAct23386615 details
STK4PARP1IntAct23386615 details
STK4MCM7IntAct23386615 details
STK4DDX5IntAct23386615 details
STK4MTHFD1IntAct23386615 details
STK4ARF1IntAct23386615 details
STK4STAT1IntAct23386615 details
STK4IQGAP1IntAct23386615 details
STK4EIF3BIntAct23386615 details
STK4EPPK1IntAct23386615 details
STK4DNAJA1IntAct23386615 details
STK4CLTCIntAct23386615 details
STK4NCLIntAct23386615 details
STK4RPS4XIntAct23386615 details
STK4COPB1IntAct23386615 details
STK4TCP1IntAct23386615 details
STK4STAT3IntAct23386615 details
STK4IQGAP2IntAct23386615 details
STK4PRDX2IntAct23386615 details
STK4PAK3IntAct23386615 details
STK4HDLBPIntAct23386615 details
STK4PABPC1IntAct23386615 details
STK4IPO4IntAct23386615 details
STK4XRCC6IntAct23386615 details
STK4CCT7IntAct23386615 details
STK4GTF2IIntAct23386615 details
STK4DRG1IntAct23386615 details
STK4DDX3XIntAct23386615 details
STK4CEP43BioGRID, IntAct26638075 details
STK4VAPBBioGRID, IntAct26186194 28514442 details
STK4BTRCBioGRID, IntAct25900982 28514442 details
STK4KIF2BBioGRID, IntAct28514442 details
STK4ZNF133BioGRID, IntAct28514442 details
STK4ZNF695BioGRID, IntAct28514442 details
STK4ADCYAP1BioGRID, IntAct26186194 28514442 details
STK4NEURL4IntAct29426014 details
STK4KDM4ABioGRID, MINT24981860 details
STK4STOML2BioGRID, MINT24981860 details
STK4TDRD3BioGRID, MINT24981860 details
STK4S100A13BioGRID22939629 details
STK4MYCBioGRID29467282 details
STK4ATG16L1BioGRID30196744 details
STK4AGRNBioGRID29872149 details
STK4PLEKHA4BioGRID31091453 details
STK4KIF14BioGRID31586073 details
STK4NR4A1BioGRID33087562 details
STK4ELAVL1BioGRID19322201 details