Entity Details

Primary name RUNX2
Entity type gene
Source Source Link

Details

PrimaryID860
RefseqGeneNG_008020
SymbolRUNX2
NameRUNX family transcription factor 2
Chromosome6
Location6p21.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-11-09
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsRUNX2_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0002062 chondrocyte differentiation
GO:0003700 DNA-binding transcription factor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030097 hemopoiesis
GO:0030182 neuron differentiation
GO:0030509 BMP signaling pathway
GO:0045595 regulation of cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0071773 cellular response to BMP stimulus
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1990837 sequence-specific double-stranded DNA binding

Diseases

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Interactions

66 interactions

InteractorPartnerSourcesPublicationsLink
RUNX2PIN1BioGRID, MINT24113655 details
RUNX2SOX9BioGRID, DIP17142326 20593410 details
RUNX2PPM1DDIP22065775 details
RUNX2YAP1BioGRID, DIP, HPRD10228168 25751140 27684187 31496812 32220262 details
RUNX2HDAC3BioGRID, HPRD15292260 18321663 details
RUNX2KAT6BBioGRID, HPRD11965546 details
RUNX2ALYREFBioGRID9119228 details
RUNX2SMAD3BioGRID, HPRD10531362 10962029 21986102 details
RUNX2JUNBioGRID, HPRD11274169 11641401 details
RUNX2FOSBioGRID, HPRD11274169 11641401 details
RUNX2ETS1BioGRID, HPRD9794229 details
RUNX2STUB1BioGRID18541707 details
RUNX2HDAC7BioGRID17997710 details
RUNX2RBM14BioGRID19585539 details
RUNX2FHL2BioGRID16079911 details
RUNX2HIVEP3BioGRID16728642 details
RUNX2SMURF2BioGRID21402695 details
RUNX2HIF1ABioGRID22351759 details
RUNX2SMAD6HPRD, IntAct16299379 details
RUNX2SMURF1BioGRID, IntAct16299379 17215250 details
RUNX2SMAD5BioGRID, Molecular Connections10531362 22966907 details
RUNX2TP73MINT25331851 details
RUNX2UBTFBioGRID, DIP, HPRD17251981 20160071 22393235 details
RUNX2HDAC6BioGRID, HPRD12391164 23618908 details
RUNX2SMAD1BioGRID10531362 10962029 17215250 20851880 details
RUNX2SMAD2BioGRID, HPRD10531362 details
RUNX2MSX2BioGRID, HPRD11683913 details
RUNX2HDAC4BioGRID, HPRD15537544 16613856 20097749 details
RUNX2HDAC5BioGRID15990875 16613856 details
RUNX2KAT2BBioGRID16613856 details
RUNX2HDAC1BioGRID16728531 21972143 22393235 details
RUNX2EP300BioGRID, HPRD12697832 16613856 16728531 20851880 details
RUNX2BMPR1ABioGRID16613856 details
RUNX2HES1BioGRID16195230 details
RUNX2XRCC6BioGRID, HPRD12145306 12145308 details
RUNX2XRCC5BioGRID, HPRD12145306 12145311 details
RUNX2CREBBPBioGRID18321663 details
RUNX2NR0B2BioGRID19594294 details
RUNX2STAT3BioGRID17702747 details
RUNX2SUV39H1BioGRID22537242 details
RUNX2WWP1BioGRID16728642 details
RUNX2PMLBioGRID15331439 details
RUNX2RB1BioGRID, HPRD15583032 details
RUNX2TP53BioGRID23618908 details
RUNX2CBFBBioGRID, HPRD12434156 23333304 28500134 31253590 details
RUNX2STAT5ABioGRID23533197 details
RUNX2SKP2BioGRID26778333 details
RUNX2WWP2BioGRID28500134 details
RUNX2CTBP2BioGRID30585266 details
RUNX2PRKCDHPRD16421932 details
RUNX2CEBPBHPRD11668178 details
RUNX2CCNB1HPRD16407259 details
RUNX2CDK1HPRD16407259 details
RUNX2ARHPRD10521447 details
RUNX2DVL2HPRD15262978 details
RUNX2MAP3K4HPRD15262978 details
RUNX2AXIN1HPRD15262978 details
RUNX2TAF1AHPRD17251981 details
RUNX2LEF1HPRD12551949 details
RUNX2MYCIntAct21150319 details
RUNX2TLE1BioGRID, DIP20160071 details
RUNX2POC5IntAct30845169 details
RUNX2CTNNB1BioGRID27684187 details
RUNX2CUL4ABioGRID30945288 details
RUNX2CUL4BBioGRID30945288 details
RUNX2CICBioGRID29844126 details