Entity Details

Primary name RC3H1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5TC82
EntryNameRC3H1_HUMAN
FullNameRoquin-1
TaxID9606
Evidenceevidence at protein level
Length1133
SequenceStatuscomplete
DateCreated2005-08-16
DateModified2021-06-02

Ontological Relatives

GenesRC3H1

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000932 P-body
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0001782 B cell homeostasis
GO:0002634 regulation of germinal center formation
GO:0002635 negative regulation of germinal center formation
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0004842 ubiquitin-protein transferase activity
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008270 zinc ion binding
GO:0010494 cytoplasmic stress granule
GO:0010608 posttranscriptional regulation of gene expression
GO:0030889 negative regulation of B cell proliferation
GO:0033962 P-body assembly
GO:0035198 miRNA binding
GO:0035613 RNA stem-loop binding
GO:0042098 T cell proliferation
GO:0043029 T cell homeostasis
GO:0043488 regulation of mRNA stability
GO:0045623 negative regulation of T-helper cell differentiation
GO:0046007 negative regulation of activated T cell proliferation
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0050852 T cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0061014 positive regulation of mRNA catabolic process
GO:0061158 3'-UTR-mediated mRNA destabilization
GO:0061470 T follicular helper cell differentiation
GO:0061630 ubiquitin protein ligase activity
GO:0071347 cellular response to interleukin-1
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:2000320 negative regulation of T-helper 17 cell differentiation
GO:2000628 regulation of miRNA metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic granule

Domains

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DomainNameCategoryType
IPR000571 Zinc finger, CCCH-typeDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027370 RING-type zinc-finger, LisH dimerisation motifDomainDomain
IPR032671 Roquin-1FamilyFamily
IPR036855 Zinc finger, CCCH-type superfamilyFamilyHomologous superfamily
IPR041523 Roquin IIDomainDomain

Diseases

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Interactions

75 interactions

InteractorPartnerSourcesPublicationsLink
RC3H1_HUMANUBE2B_HUMANBioGRID26489670 details
RC3H1_HUMANUB2D2_HUMANBioGRID26489670 details
RC3H1_HUMANUB2G2_HUMANBioGRID26489670 details
RC3H1_HUMANUBE2A_HUMANBioGRID26489670 details
RC3H1_HUMANUB2L3_HUMANBioGRID26489670 details
RC3H1_HUMANUBE2F_HUMANBioGRID26489670 details
RC3H1_HUMANUB2G1_HUMANBioGRID26489670 details
RC3H1_HUMANUBE2N_HUMANBioGRID26489670 details
RC3H1_HUMANUB2V1_HUMANBioGRID26489670 details
RC3H1_HUMANUB2V2_HUMANBioGRID26489670 details
RC3H1_HUMANNUFP2_HUMANBioGRID26170170 29352114 30209976 details
RC3H1_HUMANUCP3_HUMANBioGRID30295819 32491174 details
RC3H1_HUMANAGO2_HUMANBioGRID, IntAct25697406 29395067 details
RC3H1_HUMANDDX6_HUMANBioGRID, IntAct22939629 25697406 details
RC3H1_HUMANCNO11_HUMANBioGRID26170170 29395067 30209976 32460013 details
RC3H1_HUMANCNOT1_HUMANBioGRID26170170 29395067 30209976 32460013 details
RC3H1_HUMANCNO10_HUMANBioGRID26170170 29395067 30209976 32460013 details
RC3H1_HUMANCNOT2_HUMANBioGRID26170170 29395067 30209976 details
RC3H1_HUMANCNOT3_HUMANBioGRID26170170 29395067 30209976 details
RC3H1_HUMANCNO6L_HUMANBioGRID26170170 29395067 details
RC3H1_HUMANCNOT7_HUMANBioGRID26170170 29395067 30209976 32460013 details
RC3H1_HUMANCNOT8_HUMANBioGRID26170170 details
RC3H1_HUMANOTUD4_HUMANBioGRID26170170 29395067 30209976 details
RC3H1_HUMANPUM1_HUMANBioGRID26170170 29395067 details
RC3H1_HUMANRC3H2_HUMANBioGRID26170170 29395067 30209976 32460013 details
RC3H1_HUMANCNOT9_HUMANBioGRID26170170 29395067 30209976 32460013 details
RC3H1_HUMANTB182_HUMANBioGRID26170170 29395067 details
RC3H1_HUMANUBP2L_HUMANBioGRID26170170 29395067 details
RC3H1_HUMANIF2B2_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANZCCHV_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANPRC2A_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANYTHD2_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANPAIP2_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANATX2_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANMOV10_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANRBMS1_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANFUBP3_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANANKH1_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANHELZ_HUMANBioGRID29395067 30209976 details
RC3H1_HUMAN4ET_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANPATL1_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANRENT1_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANTDRD3_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANHNRPQ_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANHNRPC_HUMANBioGRID29395067 30209976 details
RC3H1_HUMANZ3H7A_HUMANBioGRID29395067 30995489 details
RC3H1_HUMANCEP85_HUMANBioGRID29395067 details
RC3H1_HUMANCPEB4_HUMANBioGRID29395067 details
RC3H1_HUMANMEX3B_HUMANBioGRID29395067 details
RC3H1_HUMANMKRN2_HUMANBioGRID29395067 details
RC3H1_HUMANPABP1_HUMANBioGRID29395067 32460013 details
RC3H1_HUMANPRC2B_HUMANBioGRID29395067 details
RC3H1_HUMANR3HD2_HUMANBioGRID29395067 details
RC3H1_HUMANRBM47_HUMANBioGRID29395067 details
RC3H1_HUMANAGO1_HUMANBioGRID29395067 details
RC3H1_HUMANAGO3_HUMANBioGRID29395067 details
RC3H1_HUMANRHG32_HUMANBioGRID29395067 details
RC3H1_HUMANR3HD1_HUMANBioGRID29395067 details
RC3H1_HUMANRALY_HUMANBioGRID29395067 details
RC3H1_HUMANSMG7_HUMANBioGRID29395067 details
RC3H1_HUMANTNR6B_HUMANBioGRID29395067 details
RC3H1_HUMANTNR6C_HUMANBioGRID29395067 details
RC3H1_HUMANUBP54_HUMANBioGRID29395067 details
RC3H1_HUMANRN214_HUMANBioGRID29395067 details
RC3H1_HUMANSMAP2_HUMANBioGRID29395067 details
RC3H1_HUMANTNR6A_HUMANBioGRID29395067 details
RC3H1_HUMANUNK_HUMANBioGRID29395067 details
RC3H1_HUMANXRN1_HUMANBioGRID29395067 details
RC3H1_HUMANYTHD1_HUMANBioGRID29395067 details
RC3H1_HUMANYTHD3_HUMANBioGRID29395067 details
RC3H1_HUMANTTP_HUMANBioGRID29395067 details
RC3H1_HUMANCSDE1_HUMANBioGRID29395067 details
RC3H1_HUMANATD3B_HUMANBioGRID29395067 details
RC3H1_HUMANGRRE1_HUMANBioGRID29395067 details
RC3H1_HUMANROA3_HUMANBioGRID29395067 details