Entity Details

Primary name KI21A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7Z4S6
EntryNameKI21A_HUMAN
FullNameKinesin-like protein KIF21A
TaxID9606
Evidenceevidence at protein level
Length1674
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesKIF21A

GO terms

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GOName
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0007018 microtubule-based movement
GO:0008017 microtubule binding
GO:0016887 ATP hydrolysis activity

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR001752 Kinesin motor domainDomainDomain
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR019821 Kinesin motor domain, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR027640 Kinesin-like proteinFamilyFamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR036961 Kinesin motor domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
135700 OMIMFibrosis of extraocular muscles, congenital, 1 (CFEOM1)A congenital ocular motility disorder marked by restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. It is clinically characterized by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. Patients affected by congenital fibrosis of extraocular muscles type 1 show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. The disease is caused by variants affecting the gene represented in this entry.

Interactions

5 interactions