Entity Details

Primary name DYR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86XF0
EntryNameDYR2_HUMAN
FullNameDihydrofolate reductase 2, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length187
SequenceStatuscomplete
DateCreated2005-12-20
DateModified2021-06-02

Ontological Relatives

GenesDHFR2

GO terms

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GOName
GO:0003729 mRNA binding
GO:0004146 dihydrofolate reductase activity
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006545 glycine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0046105 thymidine biosynthetic process
GO:0046452 dihydrofolate metabolic process
GO:0046653 tetrahydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
GO:0050661 NADP binding

Subcellular Location

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Subcellular Location
Mitochondrion
Mitochondrion inner membrane
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR001796 Dihydrofolate reductase domainDomainDomain
IPR012259 Dihydrofolate reductaseFamilyFamily
IPR024072 Dihydrofolate reductase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01929 5-Chloryl-2,4,6-quinazolinetriamineDrugbanksmall molecule
DB01958 5-[4-Tert-Butylphenylsulfanyl]-2,4-QuinazolinediamineDrugbanksmall molecule
DB02001 5-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-QuinazolinediamineDrugbanksmall molecule
DB02402 5-(4-Methoxyphenoxy)-2,4-QuinazolinediamineDrugbanksmall molecule
DB04163 5-Phenylsulfanyl-2,4-QuinazolinediamineDrugbanksmall molecule
DB04306 5-[(4-Methylphenyl)Sulfanyl]-2,4-QuinazolinediamineDrugbanksmall molecule
DB07862 7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINEDrugbanksmall molecule
DB08203 7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINEDrugbanksmall molecule
DB12116 Epigallocatechin gallateDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
DYR2_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details