Entity Details

Primary name CGAS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8N884
EntryNameCGAS_HUMAN
FullNameCyclic GMP-AMP synthase
TaxID9606
Evidenceevidence at protein level
Length522
SequenceStatuscomplete
DateCreated2005-07-05
DateModified2021-06-02

Ontological Relatives

GenesCGAS

GO terms

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GOName
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0002637 regulation of immunoglobulin production
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008340 determination of adult lifespan
GO:0010753 positive regulation of cGMP-mediated signaling
GO:0016032 viral process
GO:0032481 positive regulation of type I interferon production
GO:0035861 site of double-strand break
GO:0038001 paracrine signaling
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045087 innate immune response
GO:0046872 metal ion binding
GO:0050863 regulation of T cell activation
GO:0051607 defense response to virus
GO:0061501 cyclic-GMP-AMP synthase activity
GO:0071360 cellular response to exogenous dsRNA
GO:2000042 negative regulation of double-strand break repair via homologous recombination
GO:2000774 positive regulation of cellular senescence

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR024810 Mab-21 domainDomainDomain

Diseases

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