Entity Details

Primary name WWP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00308
EntryNameWWP2_HUMAN
FullNameNEDD4-like E3 ubiquitin-protein ligase WWP2
TaxID9606
Evidenceevidence at protein level
Length870
SequenceStatuscomplete
DateCreated2003-06-20
DateModified2021-06-02

Ontological Relatives

GenesWWP2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006464 cellular protein modification process
GO:0006858 extracellular transport
GO:0008134 transcription factor binding
GO:0010629 negative regulation of gene expression
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0032410 negative regulation of transporter activity
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045732 positive regulation of protein catabolic process
GO:0045746 negative regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046718 viral entry into host cell
GO:0051224 negative regulation of protein transport
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0070534 protein K63-linked ubiquitination
GO:1901016 regulation of potassium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

131 interactions

InteractorPartnerSourcesPublicationsLink
WWP2_HUMANPDLI7_HUMANBioGRID, HPRD, IntAct16189514 21516116 25071155 25416956 29892012 31048545 31515488 details
WWP2_HUMANCPSF6_HUMANBioGRID, HPRD, IntAct16189514 28514442 31048545 details
WWP2_HUMANSMAD3_HUMANBioGRID, I2D, IntAct18729074 21258410 21516116 23938591 25910212 details
WWP2_HUMANHNRL1_HUMANBioGRID, IntAct, MINT21516116 25071155 25416956 29892012 31048545 31515488 32296183 details
WWP2_HUMANWWP2_HUMANBioGRID, I2D17719543 17996703 19997087 21258410 22496338 23938591 26949039 27295432 28475870 30207403 31048545 31578285 details
WWP2_HUMANLEG9B_HUMANBioGRID, IntAct25416956 29892012 31515488 details
WWP2_HUMANRUSC1_HUMANBioGRID, IntAct25416956 details
WWP2_HUMANARRD1_HUMANBioGRID, IntAct21191027 21516116 22315426 23236378 26186194 28514442 31048545 32296183 details
WWP2_HUMANUB2E3_HUMANBioGRID, IntAct22496338 32296183 details
WWP2_HUMANSCNNB_HUMANBioGRID, HPRD11244092 12167593 details
WWP2_HUMANDIDO1_HUMANBioGRID, IntAct16189514 details
WWP2_HUMANUBP7_HUMANBioGRID, HPRD, IntAct16713569 25071155 details
WWP2_HUMANGA2L2_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANRASD1_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANRU1C_HUMANBioGRID, IntAct25416956 31048545 32296183 details
WWP2_HUMANF1892_HUMANBioGRID, IntAct25416956 28514442 29892012 31515488 details
WWP2_HUMANDCTN1_HUMANIntAct32814053 details
WWP2_HUMANWBP1_HUMANBioGRID, HPRD9169421 details
WWP2_HUMANUB2L3_HUMANBioGRID17719543 17996703 19274063 25723849 26949039 27182664 27295432 30207403 details
WWP2_HUMANP73_HUMANBioGRID25071155 31048545 details
WWP2_HUMANSF01_HUMANBioGRID, HPRD, IntAct16189514 details
WWP2_HUMANSC24D_HUMANBioGRID, MINT21516116 details
WWP2_HUMANPSMF1_HUMANBioGRID, IntAct27107012 details
WWP2_HUMANPTEN_HUMANBioGRID15717329 21532586 22427670 24063548 27295432 27852060 28475870 30016585 30849479 31592114 details
WWP2_HUMANUB2D3_HUMANBioGRID23644597 25266661 25723849 33107021 details
WWP2_HUMANUB2D1_HUMANBioGRID25723849 27295432 details
WWP2_HUMANRNF11_HUMANBioGRID, HPRD, IntAct, MINT15231748 28292929 31985874 32814053 details
WWP2_HUMANEWS_HUMANBioGRID, HPRD, IntAct16189514 31048545 details
WWP2_HUMANUBC_HUMANBioGRID, MINT19343052 22496338 23644597 23938591 25723849 details
WWP2_HUMANWIPF1_HUMANBioGRID, IntAct, MINT21516116 25416956 details
WWP2_HUMANPO5F1_HUMANbhf-ucl, BioGRID19274063 19997087 22387393 29393344 details
WWP2_HUMANPATZ1_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANDYHC1_HUMANIntAct32814053 details
WWP2_HUMANWBP2_HUMANBioGRID25071155 27578003 31048545 31578285 9169421 details
WWP2_HUMANUBE2K_HUMANBioGRID22496338 details
WWP2_HUMANPAIP1_HUMANBioGRID25266661 details
WWP2_HUMANBRCC3_HUMANBioGRID25071155 31048545 33107021 details
WWP2_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 9647693 details
WWP2_HUMANF214B_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANGGN_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANDYN2_HUMANIntAct32814053 details
WWP2_HUMANPRKN_HUMANIntAct32814053 details
WWP2_HUMANEGR2_HUMANBioGRID19651900 details
WWP2_HUMANSCN5A_HUMANBioGRID15548568 details
WWP2_HUMANNFIP1_HUMANBioGRID26186194 31048545 31578285 details
WWP2_HUMANUBB_HUMANIntAct17719543 details
WWP2_HUMANSMR3A_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANSCNNG_HUMANBioGRID, HPRD12167593 details
WWP2_HUMANNOTC3_HUMANBioGRID25356737 details
WWP2_HUMANSMAD7_HUMANBioGRID, I2D21258410 22773947 31546607 details
WWP2_HUMANVP37C_HUMANBioGRID, IntAct25416956 32296183 details
WWP2_HUMANANR44_HUMANBioGRID, IntAct25416956 31515488 details
WWP2_HUMANMED25_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANWDR5_HUMANBioGRID, IntAct25071155 31048545 32296183 details
WWP2_HUMANKLK6_HUMANIntAct32814053 details
WWP2_HUMANTADBP_HUMANIntAct32814053 details
WWP2_HUMANZN688_HUMANBioGRID26871637 details
WWP2_HUMANNHRF2_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANTRAF4_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
WWP2_HUMANSMRD1_HUMANBioGRID, IntAct31048545 32296183 details
WWP2_HUMANUB2E2_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANFXL18_HUMANIntAct29892012 details
WWP2_HUMANHD_HUMANIntAct32814053 details
WWP2_HUMANAAPK2_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANG45IP_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANPEX1_HUMANIntAct32814053 details
WWP2_HUMANSCNNA_HUMANBioGRID, HPRD12167593 details
WWP2_HUMANGRAP2_HUMANBioGRID, IntAct27107012 details
WWP2_HUMANRSMB_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANHEXB_HUMANIntAct32814053 details
WWP2_HUMANLITAF_HUMANBioGRID, IntAct25963657 32814053 details
WWP2_HUMANHTRA2_HUMANIntAct32814053 details
WWP2_HUMANSCAM3_HUMANBioGRID, HPRD19158374 details
WWP2_HUMANPSPC_HUMANBioGRID19366705 details
WWP2_HUMANUB2D2_HUMANBioGRID22496338 25071155 25723849 details
WWP2_HUMANDVL2_HUMANBioGRID25071155 26701932 31048545 31340145 details
WWP2_HUMANIFIT2_HUMANBioGRID32296183 details
WWP2_HUMANTPP1_HUMANIntAct32814053 details
WWP2_HUMANARRD3_HUMANBioGRID, IntAct23236378 26490116 29416926 32296183 details
WWP2_HUMANUB2J2_HUMANBioGRID22496338 details
WWP2_HUMANVASP_HUMANBioGRID, HPRD, IntAct16189514 details
WWP2_HUMANUB2R1_HUMANBioGRID22496338 details
WWP2_HUMANSPART_HUMANBioGRID19307600 25071155 details
WWP2_HUMANUBTD1_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANEFCB3_HUMANBioGRID, IntAct32296183 details
WWP2_HUMANTCPE_HUMANIntAct32814053 details
WWP2_HUMANPRPS1_HUMANIntAct32814053 details
WWP2_HUMANJPH3_HUMANIntAct32814053 details
WWP2_HUMANSYUA_HUMANIntAct32814053 details
WWP2_HUMANCATD_HUMANIntAct32814053 details
WWP2_HUMANUBA1_HUMANIntAct32814053 details
WWP2_HUMANWFS1_HUMANIntAct32814053 details
WWP2_HUMANUB2E1_HUMANBioGRID19274063 details
WWP2_HUMANACK1_HUMANBioGRID19144635 details
WWP2_HUMANCLN6_HUMANIntAct32814053 details
WWP2_HUMANUBC9_HUMANBioGRID27852060 details
WWP2_HUMANRED1_HUMANBioGRID, MINT21847096 details
WWP2_HUMANNFIP2_HUMANBioGRID, HPRD15252135 20522958 details
WWP2_HUMANPTC1_HUMANBioGRID25092867 details
WWP2_HUMANSMAD2_HUMANBioGRID, I2D, IntAct18729074 21258410 details
WWP2_HUMANDAG1_HUMANHPRD9169421 details
WWP2_HUMANWWP1_HUMANBioGRID25071155 31048545 details
WWP2_HUMANFXL15_HUMANBioGRID, MINT21572392 details
WWP2_HUMANPDC6I_HUMANBioGRID26490116 details
WWP2_HUMANRASA1_HUMANHPRD9169421 details
WWP2_HUMANCP131_HUMANBioGRID21956701 details
WWP2_HUMANPTN14_HUMANBioGRID22948661 25071155 31048545 details
WWP2_HUMANTM127_HUMANBioGRID32526160 details
WWP2_HUMANRPB1_HUMANBioGRID, IntAct28514442 31048545 details
WWP2_HUMANBRAF_HUMANBioGRID31015455 details
WWP2_HUMANXRCC5_HUMANBioGRID31048545 details
WWP2_HUMANRUNX2_HUMANBioGRID28500134 details
WWP2_HUMANSTAT3_HUMANBioGRID31048545 32627301 details
WWP2_HUMANPABP1_HUMANBioGRID25266661 31048545 details
WWP2_HUMANPARP1_HUMANBioGRID31048545 32139900 details
WWP2_HUMANAP2A_HUMANHPRD9169421 details
WWP2_HUMANSMAD6_HUMANBioGRID24850914 details
WWP2_HUMANCDN1B_HUMANBioGRID31430374 details
WWP2_HUMANCLCN5_HUMANHPRD9169421 details
WWP2_HUMANIL2RG_HUMANHPRD9169421 details
WWP2_HUMANPPM1G_HUMANBioGRID25071155 details
WWP2_HUMANSIR1_HUMANBioGRID32627301 details
WWP2_HUMANMYC_HUMANBioGRID26894970 details
WWP2_HUMANASPP2_HUMANBioGRID, HPRD31048545 9169421 details
WWP2_HUMANPSD10_HUMANBioGRID22387393 details
WWP2_HUMANS1PR1_HUMANBioGRID21555855 details
WWP2_HUMANEIF3A_HUMANBioGRID25266661 31048545 details
WWP2_HUMANIL6RA_HUMANHPRD9169421 details
WWP2_HUMANUBIP1_HUMANBioGRID21956701 details
WWP2_HUMANBAG6_HUMANBioGRID24981174 details
WWP2_HUMANSEPT4_HUMANBioGRID31924572 details