Entity Details

Primary name MADD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WXG6
EntryNameMADD_HUMAN
FullNameMAP kinase-activating death domain protein
TaxID9606
Evidenceevidence at protein level
Length1647
SequenceStatuscomplete
DateCreated2007-02-20
DateModified2021-06-02

Ontological Relatives

GenesMADD

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005123 death receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007166 cell surface receptor signaling pathway
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016021 integral component of membrane
GO:0030295 protein kinase activator activity
GO:0032483 regulation of Rab protein signal transduction
GO:0042981 regulation of apoptotic process
GO:0045202 synapse
GO:0051726 regulation of cell cycle
GO:0097194 execution phase of apoptosis
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001236 regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001194 cDENN domainDomainDomain
IPR005112 dDENN domainDomainDomain
IPR005113 uDENN domainDomainDomain
IPR037516 Tripartite DENN domainDomainDomain
IPR039980 MAP kinase-activating death domain proteinFamilyFamily
IPR043153 DENN domain, C-terminal lobeFamilyHomologous superfamily

Diseases

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