Entity Details

Primary name TSC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92574
EntryNameTSC1_HUMAN
FullNameHamartin
TaxID9606
Evidenceevidence at protein level
Length1164
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesTSC1

GO terms

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GOName
GO:0001822 kidney development
GO:0001843 neural tube closure
GO:0001952 regulation of cell-matrix adhesion
GO:0002250 adaptive immune response
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006407 rRNA export from nucleus
GO:0006417 regulation of translation
GO:0006813 potassium ion transport
GO:0007160 cell-matrix adhesion
GO:0008285 negative regulation of cell population proliferation
GO:0008344 adult locomotory behavior
GO:0010977 negative regulation of neuron projection development
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016239 positive regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0017148 negative regulation of translation
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0030027 lamellipodium
GO:0030030 cell projection organization
GO:0030426 growth cone
GO:0030544 Hsp70 protein binding
GO:0032007 negative regulation of TOR signaling
GO:0032780 negative regulation of ATPase activity
GO:0032794 GTPase activating protein binding
GO:0032868 response to insulin
GO:0032991 protein-containing complex
GO:0033596 TSC1-TSC2 complex
GO:0034260 negative regulation of GTPase activity
GO:0042030 ATPase inhibitor activity
GO:0042552 myelination
GO:0043379 memory T cell differentiation
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0044877 protein-containing complex binding
GO:0045792 negative regulation of cell size
GO:0045859 regulation of protein kinase activity
GO:0046323 glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0047485 protein N-terminus binding
GO:0048471 perinuclear region of cytoplasm
GO:0050808 synapse organization
GO:0050821 protein stabilization
GO:0051087 chaperone binding
GO:0051492 regulation of stress fiber assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051726 regulation of cell cycle
GO:0051879 Hsp90 protein binding
GO:0051894 positive regulation of focal adhesion assembly
GO:0055007 cardiac muscle cell differentiation
GO:0090630 activation of GTPase activity
GO:0090650 cellular response to oxygen-glucose deprivation
GO:0101031 chaperone complex
GO:1901214 regulation of neuron death
GO:1903204 negative regulation of oxidative stress-induced neuron death

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR007483 HamartinFamilyFamily

Diseases

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Interactions

200 interactions

InteractorPartnerSourcesPublicationsLink
TSC1_HUMANBEX3_HUMANIntAct17355907 details
TSC1_HUMANFRIH_HUMANIntAct, MINT17355907 21653829 details
TSC1_HUMANMAT1_HUMANIntAct17355907 details
TSC1_HUMANSDCG8_HUMANIntAct17355907 details
TSC1_HUMANTSC1_HUMANBioGRID, IntAct10585443 17355907 28205554 28561026 details
TSC1_HUMANHBA_HUMANIntAct17355907 details
TSC1_HUMANRFIP5_HUMANIntAct17355907 details
TSC1_HUMANCD63_HUMANIntAct17355907 details
TSC1_HUMANNDUBA_HUMANIntAct17355907 details
TSC1_HUMANID3_HUMANIntAct17355907 details
TSC1_HUMANRASA1_HUMANIntAct17355907 details
TSC1_HUMANACTB_HUMANIntAct17355907 details
TSC1_HUMANACTA_HUMANIntAct17355907 details
TSC1_HUMANSFPQ_HUMANIntAct17355907 details
TSC1_HUMANEIF3F_HUMANIntAct17355907 details
TSC1_HUMANRASF7_HUMANIntAct17355907 details
TSC1_HUMANIKKB_HUMANBioGRID, IntAct17693255 details
TSC1_HUMANTSC2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10585443 10807585 10915759 11175345 11290735 11741832 11741833 12176984 12511557 12869586 14551205 14651849 15340059 15342917 15851026 15851513 15963462 16339216 16424383 16464865 16636147 17077083 17658474 17693255 20166753 20169078 20412061 21134130 25263562 28561026 30514904 9580671 9809973 details
TSC1_HUMANMK14_HUMANBioGRID, IntAct20368287 28205554 details
TSC1_HUMANBECN1_HUMANBioGRID, IntAct20562859 28205554 details
TSC1_HUMANATX1_HUMANBioGRID, IntAct23275563 32296183 details
TSC1_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
TSC1_HUMANANM6_HUMANBioGRID, MINT23455924 details
TSC1_HUMANSH22A_HUMANBioGRID, IntAct25814554 details
TSC1_HUMANHSH2D_HUMANBioGRID, IntAct25814554 details
TSC1_HUMANTNS2_HUMANBioGRID, IntAct25814554 details
TSC1_HUMANDP13B_HUMANBioGRID, IntAct25814554 details
TSC1_HUMANDOK5_HUMANBioGRID, IntAct25814554 details
TSC1_HUMANRIN3_HUMANBioGRID, IntAct25814554 details
TSC1_HUMANTBCD7_HUMANBioGRID, HPRD, IntAct17658474 26186194 28514442 28561026 details
TSC1_HUMANPCNA_HUMANUniProt26030842 details
TSC1_HUMANMOES_HUMANBioGRID, HPRD12226091 details
TSC1_HUMAN1433Z_HUMANBioGRID, HPRD12176984 details
TSC1_HUMANAKT1_HUMANBioGRID, HPRD12167664 15342917 28205554 details
TSC1_HUMANNFL_HUMANBioGRID, HPRD12226091 details
TSC1_HUMANRHEB_HUMANBioGRID12820960 30514904 details
TSC1_HUMANCDK1_HUMANBioGRID, HPRD11444800 14551205 details
TSC1_HUMANMYC_HUMANBioGRID28205554 29467282 details
TSC1_HUMANPLK2_HUMANBioGRID20054236 details
TSC1_HUMANAURKA_HUMANBioGRID28205554 details
TSC1_HUMANMERL_HUMANBioGRID, HPRD12226091 28205554 details
TSC1_HUMANCCNE1_HUMANBioGRID28205554 details
TSC1_HUMANARAF_HUMANBioGRID28205554 details
TSC1_HUMANCCND2_HUMANBioGRID28205554 details
TSC1_HUMANCDK4_HUMANBioGRID28205554 details
TSC1_HUMANCDK6_HUMANBioGRID28205554 details
TSC1_HUMANCDN2A_HUMANBioGRID28205554 details
TSC1_HUMANARF_HUMANBioGRID28205554 details
TSC1_HUMANKAT2A_HUMANBioGRID28205554 details
TSC1_HUMANMP2K5_HUMANBioGRID28205554 details
TSC1_HUMANRASF1_HUMANBioGRID28205554 details
TSC1_HUMANSOX4_HUMANBioGRID28205554 details
TSC1_HUMANCDN2B_HUMANBioGRID28205554 details
TSC1_HUMANFGFR4_HUMANBioGRID28205554 details
TSC1_HUMANLATS2_HUMANBioGRID28205554 details
TSC1_HUMANMYLIP_HUMANBioGRID32296183 details
TSC1_HUMANAP2D_HUMANBioGRID32296183 details
TSC1_HUMANHXC8_HUMANBioGRID32296183 details
TSC1_HUMANDMRT3_HUMANBioGRID32296183 details
TSC1_HUMANPITX1_HUMANBioGRID32296183 details
TSC1_HUMANYPEL3_HUMANBioGRID32296183 details
TSC1_HUMANPATZ1_HUMANBioGRID32296183 details
TSC1_HUMANCSTF2_HUMANBioGRID32296183 details
TSC1_HUMANTLE5_HUMANBioGRID32296183 details
TSC1_HUMANLENG1_HUMANBioGRID32296183 details
TSC1_HUMANSMG9_HUMANBioGRID32296183 details
TSC1_HUMANCHCH2_HUMANBioGRID32296183 details
TSC1_HUMANPO6F2_HUMANBioGRID32296183 details
TSC1_HUMANTSH3_HUMANBioGRID32296183 details
TSC1_HUMANENKD1_HUMANBioGRID32296183 details
TSC1_HUMANF110A_HUMANBioGRID32296183 details
TSC1_HUMANGLIS2_HUMANBioGRID32296183 details
TSC1_HUMANRBTN2_HUMANBioGRID32296183 details
TSC1_HUMANVEZF1_HUMANBioGRID32296183 details
TSC1_HUMANSPAG8_HUMANBioGRID32296183 details
TSC1_HUMANFRS3_HUMANBioGRID32296183 details
TSC1_HUMANSUOX_HUMANBioGRID32296183 details
TSC1_HUMANCA094_HUMANBioGRID32296183 details
TSC1_HUMANPOGZ_HUMANBioGRID32296183 details
TSC1_HUMANPPR18_HUMANBioGRID32296183 details
TSC1_HUMANCC120_HUMANBioGRID32296183 details
TSC1_HUMANSHC3_HUMANBioGRID32296183 details
TSC1_HUMANTF7L2_HUMANBioGRID32296183 details
TSC1_HUMANTBX6_HUMANBioGRID32296183 details
TSC1_HUMANVENTX_HUMANBioGRID32296183 details
TSC1_HUMANCCL28_HUMANBioGRID32296183 details
TSC1_HUMANBAG3_HUMANBioGRID32296183 details
TSC1_HUMANZIC1_HUMANBioGRID32296183 details
TSC1_HUMANRBPMS_HUMANBioGRID32296183 details
TSC1_HUMANFOXH1_HUMANBioGRID32296183 details
TSC1_HUMANPPR32_HUMANBioGRID32296183 details
TSC1_HUMANIGFN1_HUMANBioGRID32296183 details
TSC1_HUMANMYOZ3_HUMANBioGRID32296183 details
TSC1_HUMANPATL1_HUMANBioGRID32296183 details
TSC1_HUMANVP37C_HUMANBioGRID32296183 details
TSC1_HUMANHAIR_HUMANBioGRID32296183 details
TSC1_HUMANF222B_HUMANBioGRID32296183 details
TSC1_HUMANZN417_HUMANBioGRID32296183 details
TSC1_HUMANRIN1_HUMANBioGRID32296183 details
TSC1_HUMANT10IP_HUMANBioGRID32296183 details
TSC1_HUMANSAMD7_HUMANBioGRID32296183 details
TSC1_HUMANSAM11_HUMANBioGRID32296183 details
TSC1_HUMANZN765_HUMANBioGRID32296183 details
TSC1_HUMANARI5A_HUMANBioGRID32296183 details
TSC1_HUMANZN587_HUMANBioGRID32296183 details
TSC1_HUMANGPAN1_HUMANBioGRID32296183 details
TSC1_HUMANVGLL3_HUMANBioGRID32296183 details
TSC1_HUMANAQP1_HUMANBioGRID32296183 details
TSC1_HUMANRADI_HUMANHPRD10806479 details
TSC1_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 28514442 details
TSC1_HUMAN1433B_HUMANBioGRID, HPRD, IntAct, MINT12176984 15324660 28514442 details
TSC1_HUMAN1433F_HUMANHPRD, IntAct12176984 17979178 28514442 details
TSC1_HUMANETS1_HUMANIntAct20195357 details
TSC1_HUMAN1433T_HUMANHPRD, IntAct12176984 28514442 details
TSC1_HUMANDISC1_HUMANIntAct31413325 details
TSC1_HUMANKLH20_HUMANIntAct32814053 details
TSC1_HUMANTANK_HUMANMINT21653829 details
TSC1_HUMANPICK1_HUMANMINT21653829 details
TSC1_HUMANKAZRN_HUMANMINT21653829 details
TSC1_HUMANAKIB1_HUMANMINT21653829 details
TSC1_HUMANACTN2_HUMANMINT21653829 details
TSC1_HUMANACTN1_HUMANMINT21653829 details
TSC1_HUMANABI1_HUMANMINT21653829 details
TSC1_HUMANATN1_HUMANMINT21653829 details
TSC1_HUMANANR24_HUMANMINT21653829 details
TSC1_HUMANANR35_HUMANMINT21653829 details
TSC1_HUMANGEMI8_HUMANMINT21653829 details
TSC1_HUMANGFAP_HUMANMINT21653829 details
TSC1_HUMANFBF1_HUMANMINT21653829 details
TSC1_HUMANEIF3A_HUMANMINT21653829 details
TSC1_HUMANDCTN2_HUMANMINT21653829 details
TSC1_HUMANDACH2_HUMANMINT21653829 details
TSC1_HUMANCTNB1_HUMANMINT21653829 details
TSC1_HUMANCOG6_HUMANMINT21653829 details
TSC1_HUMANCNTRB_HUMANMINT21653829 details
TSC1_HUMANCNIH1_HUMANMINT21653829 details
TSC1_HUMANCNTRL_HUMANMINT21653829 details
TSC1_HUMANCDR2_HUMANMINT21653829 details
TSC1_HUMANCC88B_HUMANMINT21653829 details
TSC1_HUMANCASC3_HUMANMINT21653829 details
TSC1_HUMANCACO2_HUMANMINT21653829 details
TSC1_HUMANMSD3_HUMANMINT21653829 details
TSC1_HUMANKANL2_HUMANMINT21653829 details
TSC1_HUMANBEND5_HUMANMINT21653829 details
TSC1_HUMANBC11A_HUMANMINT21653829 details
TSC1_HUMANAXIN1_HUMANBioGRID, MINT12511557 21653829 details
TSC1_HUMANPHLB1_HUMANMINT21653829 details
TSC1_HUMANNRBF2_HUMANMINT21653829 details
TSC1_HUMANNKD2_HUMANMINT21653829 details
TSC1_HUMANNINL_HUMANBioGRID, MINT21653829 28718761 details
TSC1_HUMANNECA2_HUMANMINT21653829 details
TSC1_HUMANNU1M_HUMANMINT21653829 details
TSC1_HUMANMBP_HUMANMINT21653829 details
TSC1_HUMANMBIP1_HUMANMINT21653829 details
TSC1_HUMANLZTS2_HUMANMINT21653829 details
TSC1_HUMANLUC7L_HUMANMINT21653829 details
TSC1_HUMANLRSM1_HUMANMINT21653829 details
TSC1_HUMANCC160_HUMANMINT21653829 details
TSC1_HUMANKLC4_HUMANMINT21653829 details
TSC1_HUMANKLC1_HUMANMINT21653829 details
TSC1_HUMANKIF5A_HUMANMINT21653829 details
TSC1_HUMANKIF1C_HUMANMINT21653829 details
TSC1_HUMANICA69_HUMANMINT21653829 details
TSC1_HUMANHOOK2_HUMANMINT21653829 details
TSC1_HUMANHOME3_HUMANMINT21653829 details
TSC1_HUMANHNRPM_HUMANMINT21653829 details
TSC1_HUMANHGS_HUMANMINT21653829 details
TSC1_HUMANHECW1_HUMANMINT21653829 details
TSC1_HUMANGPTC1_HUMANMINT21653829 details
TSC1_HUMANGOGA2_HUMANMINT21653829 details
TSC1_HUMANGCC1_HUMANMINT21653829 details
TSC1_HUMANZN423_HUMANMINT21653829 details
TSC1_HUMANVIME_HUMANMINT21653829 details
TSC1_HUMANTARA_HUMANMINT21653829 details
TSC1_HUMANTRIM3_HUMANMINT21653829 details
TSC1_HUMANTFP11_HUMANMINT21653829 details
TSC1_HUMANSPAG5_HUMANMINT21653829 details
TSC1_HUMANSHAN1_HUMANMINT21653829 details
TSC1_HUMANSRTD1_HUMANMINT21653829 details
TSC1_HUMANSELW_HUMANMINT21653829 details
TSC1_HUMANSC31A_HUMANMINT21653829 details
TSC1_HUMANSCMH1_HUMANMINT21653829 details
TSC1_HUMANRUN3A_HUMANMINT21653829 details
TSC1_HUMANRALYL_HUMANMINT21653829 details
TSC1_HUMANLIPA2_HUMANMINT21653829 details
TSC1_HUMANEZRI_HUMANBioGRID, HPRD10806479 details
TSC1_HUMANACTS_HUMANBioGRID10806479 details
TSC1_HUMANPLK1_HUMANBioGRID, HPRD16339216 details
TSC1_HUMANKS6A1_HUMANBioGRID15342917 details
TSC1_HUMANGSK3B_HUMANBioGRID12511557 details
TSC1_HUMANAMD_HUMANBioGRID14559897 details
TSC1_HUMANFAK1_HUMANBioGRID17043358 details
TSC1_HUMANDOCK7_HUMANBioGRID15963462 details
TSC1_HUMANFBXW5_HUMANBioGRID18381890 details
TSC1_HUMANCDN1B_HUMANBioGRID15355997 details
TSC1_HUMAN1433E_HUMANBioGRID, HPRD12176984 17979178 19608861 23472066 details
TSC1_HUMANESR1_HUMANBioGRID15851513 details
TSC1_HUMANRRAGA_HUMANBioGRID24529380 details
TSC1_HUMANRRAGC_HUMANBioGRID24529380 details
TSC1_HUMANCCNB1_HUMANHPRD11444800 details