Entity Details

Primary name SORL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92673
EntryNameSORL_HUMAN
FullNameSortilin-related receptor
TaxID9606
Evidenceevidence at protein level
Length2214
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesSORL1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001540 amyloid-beta binding
GO:0002024 diet induced thermogenesis
GO:0004888 transmembrane signaling receptor activity
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005615 extracellular space
GO:0005641 nuclear envelope lumen
GO:0005768 endosome
GO:0005769 early endosome
GO:0005771 multivesicular body
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006605 protein targeting
GO:0006622 protein targeting to lysosome
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006898 receptor-mediated endocytosis
GO:0007218 neuropeptide signaling pathway
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010897 negative regulation of triglyceride catabolic process
GO:0014910 regulation of smooth muscle cell migration
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030169 low-density lipoprotein particle binding
GO:0030514 negative regulation of BMP signaling pathway
GO:0030658 transport vesicle membrane
GO:0031267 small GTPase binding
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031901 early endosome membrane
GO:0031985 Golgi cisterna
GO:0032091 negative regulation of protein binding
GO:0032585 multivesicular body membrane
GO:0034067 protein localization to Golgi apparatus
GO:0038020 insulin receptor recycling
GO:0042923 neuropeptide binding
GO:0043407 negative regulation of MAP kinase activity
GO:0045053 protein retention in Golgi apparatus
GO:0045732 positive regulation of protein catabolic process
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0050768 negative regulation of neurogenesis
GO:0051604 protein maturation
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular exosome
GO:0070863 positive regulation of protein exit from endoplasmic reticulum
GO:0097356 perinucleolar compartment
GO:1900168 positive regulation of glial cell-derived neurotrophic factor production
GO:1901215 negative regulation of neuron death
GO:1902430 negative regulation of amyloid-beta formation
GO:1902771 positive regulation of choline O-acetyltransferase activity
GO:1902948 negative regulation of tau-protein kinase activity
GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport
GO:1902955 positive regulation of early endosome to recycling endosome transport
GO:1902960 negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 positive regulation of protein localization to early endosome
GO:1902997 negative regulation of neurofibrillary tangle assembly
GO:1904179 positive regulation of adipose tissue development
GO:1990000 amyloid fibril formation
GO:1990845 adaptive thermogenesis
GO:2001137 positive regulation of endocytic recycling

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle
Early endosome membrane
Endoplasmic reticulum membrane
Endosome
Endosome membrane
Golgi apparatus
Golgi apparatus membrane
Recycling endosome membrane
Secreted

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR003961 Fibronectin type IIIDomainDomain
IPR006581 VPS10DomainDomain
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR031777 Sortilin, C-terminalDomainDomain
IPR031778 Sortilin, N-terminalDomainDomain
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
104300 OMIMAlzheimer disease (AD)Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death. The gene represented in this entry may be involved in disease pathogenesis.

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
SORL_HUMANGGA1_HUMANBioGRID, HPRD, MINT, UniProt11821067 17855360 20015111 26053850 30679749 details
SORL_HUMANGGA2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11821067 30679749 32814053 details
SORL_HUMANPP1A_HUMANBioGRID, IntAct22321011 details
SORL_HUMANAMRP_HUMANbhf-ucl, BioGRID, HPRD, IntAct11294867 11557679 17326667 26858303 28514442 8940146 details
SORL_HUMANAPOE_HUMANbhf-ucl, BioGRID11294867 17326667 details
SORL_HUMANDDT4L_HUMANIntAct32296183 details
SORL_HUMANRHOH_HUMANBioGRID, IntAct32296183 details
SORL_HUMANPO6F2_HUMANBioGRID, IntAct32296183 details
SORL_HUMANA4_HUMANBioGRID, IntAct, UniProt16174740 16407538 17855360 23283322 32814053 details
SORL_HUMANHS12A_HUMANBioGRID, UniProt30679749 details
SORL_HUMANCRLF1_HUMANIntAct26858303 details
SORL_HUMANCNTFR_HUMANIntAct26858303 details
SORL_HUMANIL6_HUMANIntAct28265003 details
SORL_HUMANIL6RA_HUMANIntAct28265003 details
SORL_HUMANGDNF_HUMANIntAct23333276 details
SORL_HUMANGFRA1_HUMANIntAct23333276 details
SORL_HUMANACHA4_HUMANIntAct32814053 details
SORL_HUMANNDUV2_HUMANIntAct32814053 details
SORL_HUMANCBX1_HUMANIntAct32814053 details
SORL_HUMANPNPH_HUMANIntAct32814053 details
SORL_HUMANIF2B_HUMANIntAct32814053 details
SORL_HUMANKAT5_HUMANIntAct32814053 details
SORL_HUMANSORT_HUMANBioGRID11294867 details
SORL_HUMANSORL_HUMANBioGRID11294867 details
SORL_HUMANCEP97_HUMANBioGRID, IntAct27173435 unassigned1312 details
SORL_HUMANRET_HUMANIntAct23333276 details
SORL_HUMANPACS1_HUMANBioGRID17855360 details
SORL_HUMANFURIN_HUMANHPRD11294867 details