Entity Details

Primary name RORB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92753
EntryNameRORB_HUMAN
FullNameNuclear receptor ROR-beta
TaxID9606
Evidenceevidence at protein level
Length470
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007601 visual perception
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008502 melatonin receptor activity
GO:0035881 amacrine cell differentiation
GO:0042462 eye photoreceptor cell development
GO:0042752 regulation of circadian rhythm
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046548 retinal rod cell development
GO:0046549 retinal cone cell development
GO:0048511 rhythmic process
GO:0060041 retina development in camera-type eye
GO:0071300 cellular response to retinoic acid
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003079 Nuclear receptor RORFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily
IPR044101 Retinoid-related orphan receptors, DNA-binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01065 MelatoninDrugbanksmall molecule