Entity Details

Primary name NHRF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14745
EntryNameNHRF1_HUMAN
FullNameNa(+)/H(+) exchange regulatory cofactor NHE-RF1
TaxID9606
Evidenceevidence at protein level
Length358
SequenceStatuscomplete
DateCreated2004-02-02
DateModified2021-06-02

Ontological Relatives

GenesSLC9A3R1

GO terms

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GOName
GO:0001726 ruffle
GO:0002009 morphogenesis of an epithelium
GO:0003096 renal sodium ion transport
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005902 microvillus
GO:0007009 plasma membrane organization
GO:0007097 nuclear migration
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007605 sensory perception of sound
GO:0008013 beta-catenin binding
GO:0008285 negative regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0008361 regulation of cell size
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0012505 endomembrane system
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0015185 gamma-aminobutyric acid transmembrane transporter activity
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016324 apical plasma membrane
GO:0017081 chloride channel regulator activity
GO:0019902 phosphatase binding
GO:0019933 cAMP-mediated signaling
GO:0022612 gland morphogenesis
GO:0030033 microvillus assembly
GO:0030036 actin cytoskeleton organization
GO:0030165 PDZ domain binding
GO:0030175 filopodium
GO:0030336 negative regulation of cell migration
GO:0030643 cellular phosphate ion homeostasis
GO:0031526 brush border membrane
GO:0031528 microvillus membrane
GO:0031698 beta-2 adrenergic receptor binding
GO:0031799 type 2 metabotropic glutamate receptor binding
GO:0031800 type 3 metabotropic glutamate receptor binding
GO:0031982 vesicle
GO:0032415 regulation of sodium:proton antiporter activity
GO:0032416 negative regulation of sodium:proton antiporter activity
GO:0032426 stereocilium tip
GO:0032782 bile acid secretion
GO:0034635 glutathione transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0043495 protein-membrane adaptor activity
GO:0043621 protein self-association
GO:0044062 regulation of excretion
GO:0044782 cilium organization
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045159 myosin II binding
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0045859 regulation of protein kinase activity
GO:0045930 negative regulation of mitotic cell cycle
GO:0047485 protein N-terminus binding
GO:0048471 perinuclear region of cytoplasm
GO:0050780 dopamine receptor binding
GO:0051683 establishment of Golgi localization
GO:0051898 negative regulation of protein kinase B signaling
GO:0051939 gamma-aminobutyric acid import
GO:0060088 auditory receptor cell stereocilium organization
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0070293 renal absorption
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070851 growth factor receptor binding
GO:0071944 cell periphery
GO:0072659 protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090660 cerebrospinal fluid circulation
GO:0097225 sperm midpiece
GO:0097291 renal phosphate ion absorption
GO:0098739 import across plasma membrane
GO:0098797 plasma membrane protein complex
GO:0150104 transport across blood-brain barrier
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell projection
Cytoplasm
Endomembrane system

Domains

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DomainNameCategoryType
IPR001478 PDZ domainDomainDomain
IPR015098 EBP50, C-terminalDomainDomain
IPR017300 Na(+)/H(+) exchange regulatory cofactor NHERF-1/2FamilyFamily
IPR031199 Na(+)/H(+) exchange regulatory cofactor NHERF-1FamilyFamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR041489 PDZ domain 6DomainDomain

Diseases

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Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
NHRF1_HUMANPHAG1_HUMANBioGRID, HPRD, MINT11684085 details
NHRF1_HUMANCLCN3_HUMANBioGRID, HPRD, IntAct11967229 12471024 details
NHRF1_HUMANCFTR_HUMANBioGRID, DIP, HPRD, IntAct, MINT10852925 11158634 12403779 12471024 12615054 15553237 17110338 17244609 19446522 26618866 28360110 9613608 9671706 9677412 details
NHRF1_HUMANMOES_HUMANBioGRID, HPRD, IntAct15020681 9430655 details
NHRF1_HUMANEZRI_HUMANBioGRID, HPRD, IntAct, MINT11285285 11684085 15020681 20937695 23414517 26344197 29568061 34079125 9314537 details
NHRF1_HUMANOPRK_HUMANBioGRID, HPRD, MINT12004055 15070904 details
NHRF1_HUMANYAP1_HUMANBioGRID, HPRD, MINT10562288 details
NHRF1_HUMANYES_HUMANBioGRID, MINT10562288 details
NHRF1_HUMANTB10A_HUMANBioGRID, HPRD, IntAct, MINT11285285 20937695 details
NHRF1_HUMANRHG17_HUMANMINT11285285 details
NHRF1_HUMANADRB2_HUMANBioGRID, HPRD, MINT11526121 11882663 9560162 9671706 details
NHRF1_HUMANP2RY2_HUMANMINT9671706 details
NHRF1_HUMANP2RY1_HUMANBioGRID, HPRD, MINT9671706 details
NHRF1_HUMANPTEN_HUMANBioGRID, HPRD, MINT, UniProt16456542 21804599 21990315 23118026 24012959 26531778 30631154 details
NHRF1_HUMANPGFRB_HUMANBioGRID, HPRD, IntAct, MINT11046132 16456542 23397142 24012959 details
NHRF1_HUMANMERL_HUMANBioGRID, HPRD, IntAct15467741 26045165 9430655 details
NHRF1_HUMANPHLP2_HUMANBioGRID, IntAct, UniProt19615732 21804599 27880917 details
NHRF1_HUMANFZD4_HUMANI2D20802536 details
NHRF1_HUMANBCL10_HUMANBioGRID, IntAct21988832 details
NHRF1_HUMANZN468_HUMANBioGRID, IntAct21988832 details
NHRF1_HUMANPHLP1_HUMANBioGRID, UniProt21804599 details
NHRF1_HUMANB2LA1_HUMANBioGRID, IntAct27107012 details
NHRF1_HUMANS26A6_HUMANIntAct12444019 details
NHRF1_HUMANAPBP2_HUMANBioGRID, IntAct32296183 details
NHRF1_HUMANDLGP4_HUMANBioGRID, IntAct32296183 details
NHRF1_HUMANRABP1_HUMANBioGRID, IntAct32296183 details
NHRF1_HUMANFA20C_HUMANIntAct22582013 details
NHRF1_HUMANNHRF1_HUMANBioGRID, DIP11046132 15070904 19446522 details
NHRF1_HUMANKCNJ1_HUMANBioGRID, HPRD14604981 details
NHRF1_HUMANSL9A3_HUMANBioGRID, HPRD14580213 details
NHRF1_HUMANNHRF3_HUMANBioGRID14531806 details
NHRF1_HUMANCTNB1_HUMANBioGRID, HPRD12830000 details
NHRF1_HUMANMRP2_HUMANBioGRID, HPRD12615054 25163515 details
NHRF1_HUMANS4A8_HUMANBioGRID, HPRD12444018 details
NHRF1_HUMANNOS2_HUMANBioGRID, HPRD12080081 details
NHRF1_HUMANPTH1R_HUMANBioGRID, HPRD12075354 details
NHRF1_HUMANPGFRA_HUMANBioGRID, HPRD11046132 11882663 details
NHRF1_HUMANSCN4A_HUMANBioGRID9677412 details
NHRF1_HUMANMRP4_HUMANBioGRID18045536 18559527 details
NHRF1_HUMANGNA11_HUMANBioGRID12193606 details
NHRF1_HUMANSKP2_HUMANBioGRID25492869 details
NHRF1_HUMANAKT1_HUMANBioGRID25492869 details
NHRF1_HUMANS4A7_HUMANBioGRID12403779 details
NHRF1_HUMANKPCA_HUMANBioGRID12954600 details
NHRF1_HUMANS13A1_HUMANBioGRID18407958 details
NHRF1_HUMANGRM2_HUMANBioGRID28392297 details
NHRF1_HUMANGRM3_HUMANBioGRID28392297 details
NHRF1_HUMANOGT1_HUMANBioGRID32994395 details
NHRF1_HUMANCNGA2_HUMANHPRD14604981 details
NHRF1_HUMANS22AB_HUMANHPRD16236806 details
NHRF1_HUMANS22A4_HUMANHPRD15553237 details
NHRF1_HUMANS22A5_HUMANHPRD15553237 details
NHRF1_HUMANS22A9_HUMANHPRD15553237 details
NHRF1_HUMANSO1A2_HUMANHPRD15553237 details
NHRF1_HUMANSO3A1_HUMANHPRD15553237 details
NHRF1_HUMANPLCB3_HUMANMINT11285285 details
NHRF1_HUMANCAN6_HUMANMINT11285285 details
NHRF1_HUMANPTPRQ_HUMANIntActunassigned1312 details
NHRF1_HUMANPLCB1_HUMANBioGRID, HPRD10980202 12193606 details
NHRF1_HUMANRACK1_HUMANBioGRID11956211 details
NHRF1_HUMANEPHB1_HUMANBioGRID23118026 details
NHRF1_HUMANU2AF2_HUMANBioGRID26641092 details
NHRF1_HUMANMK01_HUMANBioGRID20736378 details
NHRF1_HUMANCADH2_HUMANBioGRID20736378 details
NHRF1_HUMANRADI_HUMANHPRD12499563 9430655 details
NHRF1_HUMANVATB1_HUMANHPRD10748165 details
NHRF1_HUMANVATE1_HUMANHPRD10748165 details
NHRF1_HUMANTRPC5_HUMANHPRD10980202 details
NHRF1_HUMANGRK6_HUMANHPRD10446210 details
NHRF1_HUMANGNAQ_HUMANHPRD12193606 details
NHRF1_HUMANPLCB2_HUMANHPRD10980202 details
NHRF1_HUMANAKA10_HUMANHPRD14531806 details
NHRF1_HUMANNPT2A_HUMANHPRD11099500 details
NHRF1_HUMANTRPC4_HUMANHPRD10980202 details
NHRF1_HUMANLSHR_HUMANHPRD14507927 details
NHRF1_HUMANRLBP1_HUMANHPRD14744877 details
NHRF1_HUMANS26A3_HUMANHPRD12369822 details
NHRF1_HUMANEGFR_HUMANHPRD16456542 details
NHRF1_HUMANLPAR2_HUMANHPRD16203867 details