Entity Details

Primary name ITCH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96J02
EntryNameITCH_HUMAN
FullNameE3 ubiquitin-protein ligase Itchy homolog
TaxID9606
Evidenceevidence at protein level
Length903
SequenceStatuscomplete
DateCreated2003-10-03
DateModified2021-06-02

Ontological Relatives

GenesITCH

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001558 regulation of cell growth
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007219 Notch signaling pathway
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0032991 protein-containing complex
GO:0035519 protein K29-linked ubiquitination
GO:0043021 ribonucleoprotein complex binding
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0044389 ubiquitin-like protein ligase binding
GO:0045087 innate immune response
GO:0045236 CXCR chemokine receptor binding
GO:0045732 positive regulation of protein catabolic process
GO:0046329 negative regulation of JNK cascade
GO:0046718 viral entry into host cell
GO:0050687 negative regulation of defense response to virus
GO:0051607 defense response to virus
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0090085 regulation of protein deubiquitination
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1990763 arrestin family protein binding
GO:2000646 positive regulation of receptor catabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Early endosome membrane
Endosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613385 OMIMAutoimmune disease, multisystem, with facial dysmorphism (ADMFD)A disorder characterized by organomegaly, failure to thrive, developmental delay, dysmorphic features and autoimmune inflammatory cell infiltration of the lungs, liver and gut. The disease is caused by variants affecting the gene represented in this entry.

Interactions

184 interactions

InteractorPartnerSourcesPublicationsLink
ITCH_HUMANSH3G2_HUMANBioGRID, HPRD, MINT14684745 26613292 28235806 details
ITCH_HUMANCASL_HUMANBioGRID, HPRD, MINT15051726 details
ITCH_HUMANCBLC_HUMANBioGRID, HPRD, MINT12226085 details
ITCH_HUMANSGK3_HUMANBioGRID, HPRD, MINT16888620 details
ITCH_HUMANDTX1_HUMANBioGRID, HPRD, MINT17028573 18628966 details
ITCH_HUMANP73_HUMANBioGRID, DIP, HPRD, MINT15678106 17110958 17592138 30603043 32513985 details
ITCH_HUMANUBB_HUMANIntAct17719543 details
ITCH_HUMANUB2E2_HUMANBioGRID, IntAct19549727 30017913 details
ITCH_HUMANUBC_HUMANBioGRID, MINT19343052 22496338 23287719 23644597 25723849 30017913 details
ITCH_HUMANSPART_HUMANBioGRID, IntAct16055720 19307600 19580544 19765186 20504295 28514442 details
ITCH_HUMANSNX9_HUMANBioGRID, MINT20491914 details
ITCH_HUMANMAR1_HUMANBioGRID, MINT15703212 20491914 details
ITCH_HUMANRNF11_HUMANBioGRID, HPRD, I2D14559117 19131965 20676133 22507528 28292929 31985874 details
ITCH_HUMANGLI1_HUMANBioGRID, I2D20818436 31278361 details
ITCH_HUMANWASL_HUMANBioGRID, IntAct23414517 details
ITCH_HUMANCYLD_HUMANBioGRID, InnateDB22057290 details
ITCH_HUMANP4K2A_HUMANMINT23146885 details
ITCH_HUMANLRRK1_HUMANBioGRID, IntAct24947832 29513927 details
ITCH_HUMANASPP2_HUMANBioGRID, MINT25436413 28400336 details
ITCH_HUMANARRD3_HUMANBioGRID, IntAct23236378 28514442 29416926 details
ITCH_HUMANARRD1_HUMANBioGRID, IntAct21191027 23236378 23886940 26186194 28514442 details
ITCH_HUMANCPSF6_HUMANBioGRID, HPRD, IntAct16055720 26508657 28514442 details
ITCH_HUMANP63_HUMANBioGRID, DIP16908849 20855944 22935697 23370280 25485500 details
ITCH_HUMANN4BP1_HUMANBioGRID, DIP17592138 details
ITCH_HUMANERBB4_HUMANBioGRID, DIP17463226 18334649 details
ITCH_HUMANJPH3_HUMANIntAct32814053 details
ITCH_HUMANNUMB_HUMANBioGRID, HPRD12682059 18628966 20818436 details
ITCH_HUMANSCNNA_HUMANBioGRID11244092 details
ITCH_HUMANSCNNB_HUMANBioGRID11244092 details
ITCH_HUMANATN1_HUMANBioGRID, HPRD9647693 details
ITCH_HUMANCXCR4_HUMANBioGRID19116316 22275353 24489825 28264927 details
ITCH_HUMANARRB2_HUMANBioGRID17947233 18544533 details
ITCH_HUMANITCH_HUMANBioGRID, HPRD11526121 11724934 16055720 16446428 17038327 17592138 17719543 17996703 18718449 19997087 22496338 23146885 24790097 26949039 28475870 28747490 31578285 details
ITCH_HUMANNFE2_HUMANBioGRID11318614 18718448 details
ITCH_HUMANUB2L3_HUMANBioGRID15350225 15678106 17038327 17592138 17719543 17996703 18718449 20068034 22009753 25632008 25723849 26245901 26949039 27182664 29212706 29378950 29515120 29643511 30017913 details
ITCH_HUMANUSP9X_HUMANBioGRID17038327 19341794 26508657 details
ITCH_HUMANJUN_HUMANBioGRID, HPRD16901904 17110928 19806201 19818398 details
ITCH_HUMANFYN_HUMANBioGRID16387660 details
ITCH_HUMANSMAD3_HUMANBioGRID15051726 details
ITCH_HUMANRPB1_HUMANBioGRID, HPRD16055720 26508657 details
ITCH_HUMANCPSF5_HUMANBioGRID16055720 details
ITCH_HUMANUBP2L_HUMANBioGRID16055720 details
ITCH_HUMANOCLN_HUMANBioGRID, HPRD11782481 19478092 33100129 34079125 details
ITCH_HUMANMP2K4_HUMANBioGRID19737936 details
ITCH_HUMANLATS1_HUMANBioGRID21212414 21383157 23564455 24107629 28416659 34079125 details
ITCH_HUMANLAPM5_HUMANBioGRID22009753 details
ITCH_HUMANSMAD2_HUMANBioGRID15350225 details
ITCH_HUMANSTAM1_HUMANBioGRID22275353 26508657 details
ITCH_HUMANSTAM2_HUMANBioGRID22275353 details
ITCH_HUMANARHG7_HUMANBioGRID17652093 26613292 28235806 details
ITCH_HUMANKAPCA_HUMANBioGRID17437719 details
ITCH_HUMANCSK21_HUMANBioGRID17437719 details
ITCH_HUMANTXNIP_HUMANBioGRID20068034 26527736 27437069 29378950 32901881 details
ITCH_HUMANMK08_HUMANBioGRID16446428 details
ITCH_HUMANDVL2_HUMANBioGRID22826439 26701932 details
ITCH_HUMANBECN1_HUMANBioGRID21936852 details
ITCH_HUMANLITAF_HUMANBioGRID21326863 25963657 details
ITCH_HUMANGNAI2_HUMANBioGRID23071112 details
ITCH_HUMANUB2E1_HUMANBioGRID15350225 19737936 30017913 details
ITCH_HUMANUB2G1_HUMANBioGRID16446428 22826439 details
ITCH_HUMANUB2D2_HUMANBioGRID11724934 22496338 25723849 26245901 29643511 30017913 details
ITCH_HUMANUB2E3_HUMANBioGRID22496338 details
ITCH_HUMANUB2J2_HUMANBioGRID22496338 details
ITCH_HUMANUB2R1_HUMANBioGRID22496338 30017913 details
ITCH_HUMANUBE2K_HUMANBioGRID22496338 30017913 details
ITCH_HUMANPO5F1_HUMANBioGRID19997087 23255053 details
ITCH_HUMANRASF5_HUMANBioGRID23538446 32690868 details
ITCH_HUMANUB2D3_HUMANBioGRID23644597 25723849 30017913 details
ITCH_HUMANARI1A_HUMANBioGRID16055720 details
ITCH_HUMANRMP_HUMANBioGRID16055720 details
ITCH_HUMANEWS_HUMANBioGRID16055720 details
ITCH_HUMANRPB2_HUMANBioGRID16055720 details
ITCH_HUMANRPB3_HUMANBioGRID16055720 details
ITCH_HUMANRPAB1_HUMANBioGRID16055720 details
ITCH_HUMANSMRC1_HUMANBioGRID16055720 details
ITCH_HUMANSMRC2_HUMANBioGRID16055720 details
ITCH_HUMANSMCE1_HUMANBioGRID16055720 details
ITCH_HUMANDAZP1_HUMANBioGRID16055720 details
ITCH_HUMANRPAP2_HUMANBioGRID16055720 details
ITCH_HUMANHNRPL_HUMANBioGRID16055720 28611215 details
ITCH_HUMANHNRL1_HUMANBioGRID16055720 details
ITCH_HUMANCPSF7_HUMANBioGRID16055720 details
ITCH_HUMANPABP1_HUMANBioGRID16055720 details
ITCH_HUMANSF01_HUMANBioGRID16055720 details
ITCH_HUMANRPAP3_HUMANBioGRID16055720 details
ITCH_HUMANUBAP2_HUMANBioGRID16055720 details
ITCH_HUMANWBP2_HUMANBioGRID16055720 26508657 27578003 details
ITCH_HUMANDTX3L_HUMANBioGRID24790097 details
ITCH_HUMANIMB1_HUMANBioGRID23538446 details
ITCH_HUMANNFIP1_HUMANBioGRID25632008 26245901 28747490 details
ITCH_HUMANTAB1_HUMANBioGRID25714464 details
ITCH_HUMANUB2D1_HUMANBioGRID25723849 28747490 30017913 details
ITCH_HUMANGLIS3_HUMANBioGRID26147758 details
ITCH_HUMANBIN1_HUMANBioGRID26613292 28235806 details
ITCH_HUMANPACN1_HUMANBioGRID26613292 28235806 details
ITCH_HUMANITSN1_HUMANBioGRID26613292 details
ITCH_HUMANSMN_HUMANBioGRID26908624 details
ITCH_HUMANUBC12_HUMANBioGRID27245101 details
ITCH_HUMANJUNB_HUMANBioGRID27245101 28747490 details
ITCH_HUMANMALD2_HUMANBioGRID28436082 33100129 details
ITCH_HUMANSH3G1_HUMANBioGRID28235806 details
ITCH_HUMANSUFU_HUMANBioGRID29515120 details
ITCH_HUMANUBE2C_HUMANBioGRID30017913 details
ITCH_HUMANUB2D4_HUMANBioGRID30017913 details
ITCH_HUMANUBE2O_HUMANBioGRID30017913 details
ITCH_HUMANUB2Q1_HUMANBioGRID30017913 details
ITCH_HUMANUB2Q2_HUMANBioGRID30017913 details
ITCH_HUMANUB2R2_HUMANBioGRID30017913 details
ITCH_HUMANBRAF_HUMANBioGRID31015455 details
ITCH_HUMANRAF1_HUMANBioGRID31015455 details
ITCH_HUMANMP2K1_HUMANBioGRID31015455 details
ITCH_HUMANRASN_HUMANBioGRID31015455 details
ITCH_HUMANKSR1_HUMANBioGRID31015455 details
ITCH_HUMAN1433T_HUMANBioGRID31015455 details
ITCH_HUMANTMG4_HUMANBioGRID23873930 details
ITCH_HUMANCBL_HUMANBioGRID, HPRD, MINT12226085 19341794 details
ITCH_HUMAN1433S_HUMANBioGRID, MINT15778465 details
ITCH_HUMANSNX18_HUMANBioGRID, MINT20491914 details
ITCH_HUMANFXL15_HUMANBioGRID, MINT21572392 details
ITCH_HUMANP53_HUMANBioGRID, DIP16908849 18559494 21474069 32807901 details
ITCH_HUMANRIPK1_HUMANBioGRID, HPRD19131965 details
ITCH_HUMANARRB1_HUMANBioGRID17947233 18544533 details
ITCH_HUMANCFLAR_HUMANBioGRID18559494 19090833 19808964 21474069 30736843 31443721 details
ITCH_HUMANYAP1_HUMANBioGRID17110958 details
ITCH_HUMANSMAD7_HUMANBioGRID15946939 22773947 28400336 details
ITCH_HUMANHGS_HUMANBioGRID14602072 26508657 details
ITCH_HUMANBID_HUMANBioGRID20392206 details
ITCH_HUMANNFIP2_HUMANBioGRID, HPRD15252135 20522958 details
ITCH_HUMANTRPV4_HUMANBioGRID, HPRD17110928 20650893 details
ITCH_HUMANSHLB1_HUMANBioGRID19341794 details
ITCH_HUMANTR10B_HUMANBioGRID19808964 details
ITCH_HUMANTGFR1_HUMANBioGRID15350225 details
ITCH_HUMANAMOT_HUMANBioGRID22385262 23564455 24101513 details
ITCH_HUMANTAXB1_HUMANBioGRID18246070 details
ITCH_HUMANTRAF6_HUMANBioGRID18246070 details
ITCH_HUMANCAV1_HUMANBioGRID22275353 details
ITCH_HUMANMAVS_HUMANBioGRID19881509 27736772 details
ITCH_HUMANPCBP2_HUMANBioGRID19881509 details
ITCH_HUMANDVL1_HUMANBioGRID22826439 details
ITCH_HUMANDVL3_HUMANBioGRID22826439 28455968 details
ITCH_HUMANUBP12_HUMANBioGRID22778262 26811477 details
ITCH_HUMANWDR48_HUMANBioGRID22778262 details
ITCH_HUMANKLF10_HUMANBioGRID18278048 details
ITCH_HUMANMDM2_HUMANBioGRID21093410 26025930 details
ITCH_HUMANGLCM_HUMANBioGRID23255161 details
ITCH_HUMANMGRN1_HUMANBioGRID23253940 details
ITCH_HUMANNOTC1_HUMANBioGRID, HPRD12682059 23886940 details
ITCH_HUMANWWOX_HUMANBioGRID24550385 25331887 details
ITCH_HUMANSMAD6_HUMANBioGRID24850914 details
ITCH_HUMANHD_HUMANBioGRID24865853 details
ITCH_HUMANATX3_HUMANBioGRID24865853 details
ITCH_HUMANPTC1_HUMANBioGRID25092867 details
ITCH_HUMANGELS_HUMANBioGRID25246592 details
ITCH_HUMANGGA3_HUMANBioGRID25195858 details
ITCH_HUMANNCOA1_HUMANBioGRID16051665 details
ITCH_HUMANM3K7_HUMANBioGRID25632008 details
ITCH_HUMANLRAD3_HUMANBioGRID26854353 details
ITCH_HUMANIKKB_HUMANBioGRID26603838 details
ITCH_HUMANPDC6I_HUMANBioGRID26508657 details
ITCH_HUMANCOIA1_HUMANBioGRID26508657 details
ITCH_HUMANHDAC6_HUMANBioGRID26508657 details
ITCH_HUMANIMA1_HUMANBioGRID26508657 details
ITCH_HUMANLRRK2_HUMANBioGRID26508657 details
ITCH_HUMANPCNA_HUMANBioGRID26508657 details
ITCH_HUMANSCAM3_HUMANBioGRID26508657 details
ITCH_HUMANAAAT_HUMANBioGRID26508657 details
ITCH_HUMAN4F2_HUMANBioGRID26508657 details
ITCH_HUMANUBA1_HUMANBioGRID26508657 details
ITCH_HUMANUBA6_HUMANBioGRID26508657 details
ITCH_HUMANUBP5_HUMANBioGRID26508657 details
ITCH_HUMANWWP1_HUMANBioGRID26508657 details
ITCH_HUMANGEMI8_HUMANBioGRID26908624 details
ITCH_HUMANDDX20_HUMANBioGRID26908624 details
ITCH_HUMANRASF1_HUMANBioGRID27292796 details
ITCH_HUMANMTSS1_HUMANBioGRID28264927 details
ITCH_HUMANOTU1_HUMANBioGRID28416659 details
ITCH_HUMANLRP6_HUMANBioGRID28966723 details
ITCH_HUMANARAF_HUMANBioGRID31015455 details
ITCH_HUMANERBB3_HUMANBioGRID31443721 details
ITCH_HUMANAN13A_HUMANBioGRID31985874 details
ITCH_HUMANTNR1A_HUMANBioGRID32690868 details
ITCH_HUMANBAX_HUMANBioGRID32690868 details
ITCH_HUMANTRPC4_HUMANHPRD17110928 details
ITCH_HUMANTRPV1_HUMANHPRD17110928 details