Entity Details

Primary name EREG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14944
EntryNameEREG_HUMAN
FullNameProepiregulin
TaxID9606
Evidenceevidence at protein level
Length169
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesEREG

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001550 ovarian cumulus expansion
GO:0001556 oocyte maturation
GO:0001819 positive regulation of cytokine production
GO:0005154 epidermal growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0007143 female meiotic nuclear division
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009299 mRNA transcription
GO:0009653 anatomical structure morphogenesis
GO:0009887 animal organ morphogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0030216 keratinocyte differentiation
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030728 ovulation
GO:0032755 positive regulation of interleukin-6 production
GO:0038128 ERBB2 signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042327 positive regulation of phosphorylation
GO:0042700 luteinizing hormone signaling pathway
GO:0043434 response to peptide hormone
GO:0043616 keratinocyte proliferation
GO:0045089 positive regulation of innate immune response
GO:0045740 positive regulation of DNA replication
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045840 positive regulation of mitotic nuclear division
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048146 positive regulation of fibroblast proliferation
GO:0048160 primary follicle stage
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051151 negative regulation of smooth muscle cell differentiation
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0061024 membrane organization
GO:2000145 regulation of cell motility

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR015497 Epidermal growth factor receptor ligandFamilyFamily

Diseases

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Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
EREG_HUMANNINJ2_HUMANBioGRID, IntAct32296183 details
EREG_HUMANOLFM4_HUMANBioGRID, IntAct32296183 details
EREG_HUMANCXCL9_HUMANBioGRID, IntAct32296183 details
EREG_HUMANM4A13_HUMANBioGRID, IntAct32296183 details
EREG_HUMANEGFR_HUMANBioGRID, HPRD, IntAct28988771 9419975 details
EREG_HUMANERBB4_HUMANBioGRID, HPRD9419975 details