Entity Details

Primary name AT2A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14983
EntryNameAT2A1_HUMAN
FullNameSarcoplasmic/endoplasmic reticulum calcium ATPase 1
TaxID9606
Evidenceevidence at protein level
Length1001
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesATP2A1

GO terms

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GOName
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006942 regulation of striated muscle contraction
GO:0008553 P-type proton-exporting transporter activity
GO:0008637 apoptotic mitochondrial changes
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0016887 ATP hydrolysis activity
GO:0030899 calcium-dependent ATPase activity
GO:0031095 platelet dense tubular network membrane
GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0031673 H zone
GO:0031674 I band
GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0033017 sarcoplasmic reticulum membrane
GO:0034220 ion transmembrane transport
GO:0034704 calcium channel complex
GO:0034976 response to endoplasmic reticulum stress
GO:0042803 protein homodimerization activity
GO:0045988 negative regulation of striated muscle contraction
GO:0048471 perinuclear region of cytoplasm
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0051659 maintenance of mitochondrion location
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0090076 relaxation of skeletal muscle
GO:0106134 positive regulation of cardiac muscle cell contraction
GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum
GO:1903779 regulation of cardiac conduction
GO:1990036 calcium ion import into sarcoplasmic reticulum

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Sarcoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR005782 P-type ATPase, subfamily IIA, SERCA-typeFamilyFamily
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00228 EnfluraneDrugbanksmall molecule
DB01189 DesfluraneDrugbanksmall molecule
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]TriphosphateDrugbanksmall molecule
DB04444 Tetrafluoroaluminate IonDrugbanksmall molecule
DB04638 2,5-di-tert-butylhydroquinoneDrugbanksmall molecule
DB07604 (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONEDrugbanksmall molecule